TopFIND 4.0

P80075: C-C motif chemokine 8

General Information

Protein names	- C-C motif chemokine 8 - HC14 - Monocyte chemoattractant protein 2 - Monocyte chemotactic protein 2 - MCP-2 - Small-inducible cytokine A8 - MCP-2(6-76)
Gene names	CCL8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P80075

7

N-termini

5

C-termini

16

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MKVSAALLCL LLMAATFSPQ GLAQPDSVSI PITCCFNVIN RKIPIQRLES YTRITNIQCP
70 80 90
KEAVIFKTKR GKEVCADPKE RWVRDSMKHL DQIFQNLKP

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 5 C-termini - 16 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P80075-5-unknown	AALLCL...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34822
P80075-5-unknown	AALLCL...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34845
P80075-5-unknown	AALLCL...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34893
P80075-5-unknown	AALLCL...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34933
P80075-5-unknown	AALLCL...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34952
P80075-5-unknown	AALLCL...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34992
P80075-6-unknown	ALLCLL...	6		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34894
P80075-7-unknown	LLCLLL...	7		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34846
P80075-24-Pyrrolidone carboxylic acid	QPDSVS...	24	pyrrolidone carboxylic acid-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P80075-28-unknown	VSIPIT...	28		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23939
P80075-29-unknown	SIPITC...	29		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P80075-74-unknown	VCADPK...	74		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34821
P80075-74-unknown	VCADPK...	74		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34844
P80075-74-unknown	VCADPK...	74		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34874
P80075-74-unknown	VCADPK...	74		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34892
P80075-74-unknown	VCADPK...	74		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34910
P80075-74-unknown	VCADPK...	74		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34951
P80075-74-unknown	VCADPK...	74		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34991

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...MKVSAA	5	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34894
	...KVSAAL	6	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34846
	...AQPDSV	27	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23939
	...KRGKEV	73	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34821
	...KRGKEV	73	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34844
	...KRGKEV	73	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34874
	...KRGKEV	73	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34892
	...KRGKEV	73	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34910
	...KRGKEV	73	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34951
	...KRGKEV	73	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC34991
	...QNLKP	99	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP1_HUMAN	4	KVSA.\|.AALL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP12_HUMAN	4	KVSA.\|.AALL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP14_HUMAN	4	KVSA.\|.AALL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP3_HUMAN	4	KVSA.\|.AALL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP7_HUMAN	4	KVSA.\|.AALL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP8_HUMAN	4	KVSA.\|.AALL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP14_HUMAN	5	VSAA.\|.ALLC		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP12_HUMAN	6	SAAL.\|.LLCL		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP3_HUMAN	27	PDSV.\|.VSIP	inferred from experiment	unknown	MEROPS	Overall CM	McQuibban GA et al.:Matrix metalloproteinase proces... (M10.013)	12149192,
MMP1_HUMAN	73	GKEV.\|.VCAD		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP12_HUMAN	73	GKEV.\|.VCAD		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP13_HUMAN	73	GKEV.\|.VCAD		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP14_HUMAN	73	GKEV.\|.VCAD		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP2_HUMAN	73	GKEV.\|.VCAD		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP7_HUMAN	73	GKEV.\|.VCAD		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP8_HUMAN	73	GKEV.\|.VCAD		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)