Q16627: C-C motif chemokine 14

General Information

Protein names	- C-C motif chemokine 14 - Chemokine CC-1/CC-3 - HCC-1/HCC-3 - HCC-1(1-74) - NCC-2 - Small-inducible cytokine A14 - HCC-1(3-74) - HCC-1(4-74) - HCC-1(9-74)
Gene names	CCL14
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q16627

11 N-termini

7 C-termini

8 Cleavages

0 Substrates

Sequence

10 20 30 40 50 60
MKISVAAIPF FLLITIALGT KTESSSRGPY HPSECCFTYT TYKIPRQRIM DYYETNSQCS
70 80 90
KPGIVFITKR GHSVCTNPSD KWVQDYIKDM KEN

Isoforms

- Isoform HCC-3 of C-C motif chemokine 14

Sequence View

10 20 30 40 50 60
MKISVAAIPF FLLITIALGT KTESSSRGPY HPSECCFTYT TYKIPRQRIM DYYETNSQCS
70 80 90
KPGIVFITKR GHSVCTNPSD KWVQDYIKDM KEN

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 7 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q16627-1-unknown	MKISVA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt69746
Q16627-4-unknown	SVAAIP...	4	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34866
Q16627-4-unknown	SVAAIP...	4	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt194618
Q16627-7-unknown	AIPFFL...	7	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34867
Q16627-20-unknown	TKTESS...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q16627-22-unknown	TESSSR...	22	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q16627-23-unknown	ESSSRG...	23	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q16627-28-unknown	GPYHPS...	28	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q16627-28-unknown	GPYHPS...	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32096
Q16627-28-unknown	GPYHPS...	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27602
Q16627-28-unknown	GPYHPS...	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt114447
Q16627-67-unknown	ITKRGH...	67	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34981
Q16627-67-unknown	ITKRGH...	67	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196448
Q16627-71-unknown	GHSVCT...	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34979
Q16627-71-unknown	GHSVCT...	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196499
Q16627-72-unknown	HSVCTN...	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34864
Q16627-72-unknown	HSVCTN...	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196513
Q16627-73-unknown	SVCTNP...	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34868
Q16627-73-unknown	SVCTNP...	73	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196541

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KISVAA	6	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34867
...ESSSRG	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC32096
...ESSSRG	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27602
...PGIVFI	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34981
...PGIVFI	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153981
...FITKRG	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34979
...FITKRG	70	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154034
...ITKRGH	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34864
...ITKRGH	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154053
...TKRGHS	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC34868
...TKRGHS	72	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154066
...DMKEN	93	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DMKEN	93	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65364

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP12_HUMAN	3	MKIS.\|.SVAA		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP12_HUMAN	6	SVAA.\|.AIPF		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
UROK_HUMAN	27	SSRG.\|.GPYH	inferred from experiment	unknown	MEROPS	Parmentier M	Vakili J et al.:Urokinase plasminogen activator... (S01.233)	11544332,
PLMN_HUMAN	27	SSRG.\|.GPYH	inferred from experiment	unknown	MEROPS	Parmentier M	Vakili J et al.:Urokinase plasminogen activator... (S01.233)	11544332,
MMP7_HUMAN	66	IVFI.\|.ITKR		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP7_HUMAN	70	TKRG.\|.GHSV		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP12_HUMAN	71	KRGH.\|.HSVC		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,
MMP12_HUMAN	72	RGHS.\|.SVCT		MS other		Overall Lab	recMMP-Chemokine_AStarr2012A	22147696,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)