Q93088: Betaine--homocysteine S-methyltransferase 1

General Information

Protein names	- Betaine--homocysteine S-methyltransferase 1 - 2.1.1.5
Gene names	BHMT
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q93088

3 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPPVGGKKAK KGILERLNAG EIVIGDGGFV FALEKRGYVK AGPWTPEAAV EHPEAVRQLH
        70         80         90        100        110        120
REFLRAGSNV MQTFTFYASE DKLENRGNYV LEKISGQEVN EAACDIARQV ADEGDALVAG
       130        140        150        160        170        180
GVSQTPSYLS CKSETEVKKV FLQQLEVFMK KNVDFLIAEY FEHVEEAVWA VETLIASGKP
       190        200        210        220        230        240
VAATMCIGPE GDLHGVPPGE CAVRLVKAGA SIIGVNCHFD PTISLKTVKL MKEGLEAARL
       250        260        270        280        290        300
KAHLMSQPLA YHTPDCNKQG FIDLPEFPFG LEPRVATRWD IQKYAREAYN LGVRYIGGCC
       310        320        330        340        350        360
GFEPYHIRAI AEELAPERGF LPPASEKHGS WGSGLDMHTK PWVRARARKE YWENLRIASG
       370        380        390        400
RPYNPSMSKP DGWGVTKGTA ELMQQKEATT EQQLKELFEK QKFKSQ

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q93088-2-unknown	PPVGGK...	2	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q93088-2-unknown	PPVGGK...	2	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q93088-50-unknown	VEHPEA...	50	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6645
Q93088-89-unknown	YVLEKI...	89	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16765

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TPEAAV	49	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC6645
...ENRGNY	88	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16765
...KFKSQ	406	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATL1_HUMAN	49	EAAV.\|.VEHP	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
LGMN_HUMAN	88	RGNY.\|.YVLE	inferred from experiment	unknown	MEROPS	Seglen PO	Overbye A et al.:Autophagic activity measured in... (C13.004)	21610319,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)