P02787: Serotransferrin

General Information

Protein names	- Serotransferrin - Transferrin - Beta-1 metal-binding globulin - Siderophilin
Gene names	TF
Organism	Homo sapiens
Protease Family
Protease ID	S60.972
Chromosome location
UniProt ID	P02787

20 N-termini

7 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRLAVGALLV CAVLGLCLAV PDKTVRWCAV SEHEATKCQS FRDHMKSVIP SDGPSVACVK
        70         80         90        100        110        120
KASYLDCIRA IAANEADAVT LDAGLVYDAY LAPNNLKPVV AEFYGSKEDP QTFYYAVAVV
       130        140        150        160        170        180
KKDSGFQMNQ LRGKKSCHTG LGRSAGWNIP IGLLYCDLPE PRKPLEKAVA NFFSGSCAPC
       190        200        210        220        230        240
ADGTDFPQLC QLCPGCGCST LNQYFGYSGA FKCLKDGAGD VAFVKHSTIF ENLANKADRD
       250        260        270        280        290        300
QYELLCLDNT RKPVDEYKDC HLAQVPSHTV VARSMGGKED LIWELLNQAQ EHFGKDKSKE
       310        320        330        340        350        360
FQLFSSPHGK DLLFKDSAHG FLKVPPRMDA KMYLGYEYVT AIRNLREGTC PEAPTDECKP
       370        380        390        400        410        420
VKWCALSHHE RLKCDEWSVN SVGKIECVSA ETTEDCIAKI MNGEADAMSL DGGFVYIAGK
       430        440        450        460        470        480
CGLVPVLAEN YNKSDNCEDT PEAGYFAIAV VKKSASDLTW DNLKGKKSCH TAVGRTAGWN
       490        500        510        520        530        540
IPMGLLYNKI NHCRFDEFFS EGCAPGSKKD SSLCKLCMGS GLNLCEPNNK EGYYGYTGAF
       550        560        570        580        590        600
RCLVEKGDVA FVKHQTVPQN TGGKNPDPWA KNLNEKDYEL LCLDGTRKPV EEYANCHLAR
       610        620        630        640        650        660
APNHAVVTRK DKEACVHKIL RQQQHLFGSN VTDCSGNFCL FRSETKDLLF RDDTVCLAKL
       670        680        690
HDRNTYEKYL GEEYVKAVGN LRKCSTSSLL EACTFRRP

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

20 N-termini - 7 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P02787-16-unknown	LCLAVP...	16		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02787-18-unknown	LAVPDK...	18		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02787-20-unknown	VPDKTV...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P02787-20-unknown	VPDKTV...	20		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02787-45-unknown	MKSVIP...	45	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000417468
P02787-47-unknown	SVIPSD...	47		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02787-96-unknown	LKPVVA...	96	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16738
P02787-125-unknown	GFQMNQ...	125		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02787-128-unknown	MNQLRG...	128	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000419338
P02787-128-unknown	MNQLRG...	128	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000264998
P02787-260-unknown	CHLAQV...	260		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02787-453-unknown	KSASDL...	453		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02787-530-unknown	KEGYYG...	530	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16739
P02787-542-unknown	CLVEKG...	542		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02787-575-unknown	EKDYEL...	575	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16740
P02787-588-unknown	KPVEEY...	588		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02787-604-unknown	HAVVTR...	604	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16741
P02787-635-unknown	SGNFCL...	635		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02787-636-unknown	GNFCLF...	636		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02787-683-unknown	KCSTSS...	683		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02787-685-unknown	STSSLL...	685		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P02787-688-unknown	SLLEAC...	688		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LAPNNL	95	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16738
...YAVAVV	119	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000417468
...YKDCHL	261	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000419338
...CEPNNK	529	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16739
...AKNLNE	574	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16740
...ARAPNH	603	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16741
...TFRRP	698	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
LGMN_HUMAN	95	PNNL.\|.LKPV	inferred from experiment	unknown	MEROPS	Barrett AJ	Dando PM et al.:Pig kidney legumain: an asparag... (C13.004)	10215615,
LGMN_HUMAN	529	PNNK.\|.KEGY	inferred from experiment	unknown	MEROPS	Barrett AJ	Dando PM et al.:Pig kidney legumain: an asparag... (C13.004)	10215615,
LGMN_HUMAN	574	NLNE.\|.EKDY	inferred from experiment	unknown	MEROPS	Barrett AJ	Dando PM et al.:Pig kidney legumain: an asparag... (C13.004)	10215615,
LGMN_HUMAN	603	APNH.\|.HAVV	inferred from experiment	unknown	MEROPS	Barrett AJ	Dando PM et al.:Pig kidney legumain: an asparag... (C13.004)	10215615,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)