P04233: HLA class II histocompatibility antigen gamma chain

General Information

Protein names	- HLA class II histocompatibility antigen gamma chain - HLA-DR antigens-associated invariant chain - Ia antigen-associated invariant chain - Ii - p33 - CD74
Gene names	CD74
Organism	Homo sapiens
Protease Family
Protease ID	I31.002
Chromosome location
UniProt ID	P04233

8 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of HLA class II histocompatibility antigen gamma chain - Isoform 3 of HLA class II histocompatibility antigen gamma chain

Sequence View

        10         20         30         40         50         60
MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY TGFSILVTLL
        70         80         90        100        110        120
LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP PKPVSKMRMA TPLLMQALPM
       130        140        150        160        170        180
GALPQGPMQN ATKYGNMTED HVMHLLQNAD PLKVYPPLKG SFPENLRHLK NTMETIDWKV
       190        200        210        220        230        240
FESWMHHWLL FEMSRHSLEQ KPTDAPPKVL TKCQEEVSHI PAVHPGSFRP KCDENGNYLP
       250        260        270        280        290
LQCYGSIGYC WCVFPNGTEV PNTRSRGHHN CSESLELEDP SSGLGVTKQD LGPVPM         10         20         30         40         50         60
MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY TGFSILVTLL
        70         80         90        100        110        120
LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP PKPVSKMRMA TPLLMQALPM
       130        140        150        160        170        180
GALPQGPMQN ATKYGNMTED HVMHLLQNAD PLKVYPPLKG SFPENLRHLK NTMETIDWKV
       190        200        210        220        230        240
FESWMHHWLL FEMSRHSLEQ KPTDAPPKVL TKCQEEVSHI PAVHPGSFRP KCDENGNYLP
       250        260        270        280        290
LQCYGSIGYC WCVFPNGTEV PNTRSRGHHN CSESLELEDP SSGLGVTKQD LGPVPM

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

8 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P04233-1-unknown	MHRRRS...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P04233-1-unknown	MHRRRS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76953
P04233-1-unknown	MHRRRS...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt76954
P04233-23-unknown	LISNNE...	23	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165112
P04233-23-unknown	LISNNE...	23	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165113
P04233-23-	LISNNE...	23		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P04233-23-	LISNNE...	23		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P04233-23-	LISNNE...	23		Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
P04233-28-unknown	EQLPML...	28	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16742
P04233-28-unknown	EQLPML...	28	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137403
P04233-28-unknown	EQLPML...	28	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt137404
P04233-69-unknown	YFLYQQ...	69	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177287
P04233-69-unknown	YFLYQQ...	69	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt177288
P04233-69-	YFLYQQ...	69		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
P04233-93-unknown	LRMKLP...	93	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16745
P04233-93-unknown	LRMKLP...	93	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142004
P04233-93-unknown	LRMKLP...	93	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142006
P04233-172-unknown	TMETID...	172	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16748
P04233-172-unknown	TMETID...	172	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt145590

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LISNNE	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16742
...LISNNE	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120360
...LISNNE	27	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120361
...LQLENL	92	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16745
...LQLENL	92	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125185
...LQLENL	92	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125187
...RHLKNT	171	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16748
...RHLKNT	171	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128888
...GPVPM	296	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...GPVPM	296	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72571

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Evidence name
LGMN_HUMAN	27	SNNE.\|.EQLP	inferred from experiment	unknown	MEROPS	Merops LGMN_HUMAN -> HG2A_HUMAN @27
LGMN_HUMAN	92	LENL.\|.LRMK	inferred from experiment	unknown	MEROPS	Merops LGMN_HUMAN -> HG2A_HUMAN @92
LGMN_HUMAN	171	LKNT.\|.TMET	inferred from experiment	unknown	MEROPS	Merops LGMN_HUMAN -> HG2A_HUMAN @171

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)