Q9BYT8: Neurolysin, mitochondrial

General Information

Protein names	- Neurolysin, mitochondrial - 3.4.24.16 - Angiotensin-binding protein - Microsomal endopeptidase - MEP - Mitochondrial oligopeptidase M - Neurotensin endopeptidase
Gene names	NLN
Organism	Homo sapiens
Protease Family	M03.002
Protease ID	M03.002
Chromosome location
UniProt ID	Q9BYT8

12 N-termini

7 C-termini

6 Cleavages

4 Substrates

Sequence

        10         20         30         40         50         60
MIARCLLAVR SLRRVGGSRI LLRMTLGREV MSPLQAMSSY TVAGRNVLRW DLSPEQIKTR
        70         80         90        100        110        120
TEELIVQTKQ VYDAVGMLGI EEVTYENCLQ ALADVEVKYI VERTMLDFPQ HVSSDKEVRA
       130        140        150        160        170        180
ASTEADKRLS RFDIEMSMRG DIFERIVHLQ ETCDLGKIKP EARRYLEKSI KMGKRNGLHL
       190        200        210        220        230        240
PEQVQNEIKS MKKRMSELCI DFNKNLNEDD TFLVFSKAEL GALPDDFIDS LEKTDDDKYK
       250        260        270        280        290        300
ITLKYPHYFP VMKKCCIPET RRRMEMAFNT RCKEENTIIL QQLLPLRTKV AKLLGYSTHA
       310        320        330        340        350        360
DFVLEMNTAK STSRVTAFLD DLSQKLKPLG EAEREFILNL KKKECKDRGF EYDGKINAWD
       370        380        390        400        410        420
LYYYMTQTEE LKYSIDQEFL KEYFPIEVVT EGLLNTYQEL LGLSFEQMTD AHVWNKSVTL
       430        440        450        460        470        480
YTVKDKATGE VLGQFYLDLY PREGKYNHAA CFGLQPGCLL PDGSRMMAVA ALVVNFSQPV
       490        500        510        520        530        540
AGRPSLLRHD EVRTYFHEFG HVMHQICAQT DFARFSGTNV ETDFVEVPSQ MLENWVWDVD
       550        560        570        580        590        600
SLRRLSKHYK DGSPIADDLL EKLVASRLVN TGLLTLRQIV LSKVDQSLHT NTSLDAASEY
       610        620        630        640        650        660
AKYCSEILGV AATPGTNMPA TFGHLAGGYD GQYYGYLWSE VFSMDMFYSC FKKEGIMNPE
       670        680        690        700
VGMKYRNLIL KPGGSLDGMD MLHNFLKREP NQKAFLMSRG LHAP

Isoforms

Sequence View

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Evidence Codes:

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Evidence Names:

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Protein Neighborhood

Domains & Features

12 N-termini - 7 C-termini - 6 Cleavages - 4 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BYT8-38-	SSYTVA...	38		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9BYT8-38-unknown	SSYTVA...	38	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BYT8-38-unknown	SSYTVA...	38	inferred from similarity	unknown	UniProtKB		inferred from uniprot (by similarity)
Q9BYT8-39-	SYTVAG...	39		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q9BYT8-105-unknown	MLDFPQ...	105	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000423214
Q9BYT8-116-unknown	KEVRAA...	116	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2755
Q9BYT8-127-unknown	KRLSRF...	127	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2756
Q9BYT8-211-unknown	TFLVFS...	211	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2757
Q9BYT8-238-unknown	KYKITL...	238	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2758
Q9BYT8-273-unknown	KEENTI...	273	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000427417
Q9BYT8-354-unknown	GKINAW...	354	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2759
Q9BYT8-402-unknown	GLSFEQ...	402	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000426959
Q9BYT8-524-unknown	FVEVPS...	524	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2760

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HVSSDK	115	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2755
...STEADK	126	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2756
...LNEDDT	210	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2757
...KTDDDK	237	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2758
...GFEYDG	353	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2759
...NVETDF	523	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2760
...GLHAP	704	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP6_HUMAN	115	SSDK.\|.KEVR	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	126	EADK.\|.KRLS	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	210	EDDT.\|.TFLV	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	237	DDDK.\|.KYKI	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	353	EYDG.\|.GKIN	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,
CASP6_HUMAN	523	ETDF.\|.FVEV	inferred from experiment	unknown	MEROPS	Leblanc AC	Klaiman G et al.:Targets of caspase-6 activity i... (C14.005)	18487604,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
NEUT_HUMAN	160	RRPY.\|.YILK	inferred from experiment	unknown	MEROPS		Merops NEUL_HUMAN -> NEUT_HUMAN @160
PDYN_HUMAN	211	GFLR.\|.RRIR	inferred from experiment	unknown	MEROPS	Barrett AJ	Serizawa A et al.:Characterization of a mitochond... (M03.002)	7836437,
PDYN_HUMAN	217	RPKL.\|.LKWD	inferred from experiment	unknown	MEROPS	Barrett AJ	Serizawa A et al.:Characterization of a mitochond... (M03.002)	7836437,
PDYN_HUMAN	218	PKLK.\|.KWDN	inferred from experiment	unknown	MEROPS	Barrett AJ	Serizawa A et al.:Characterization of a mitochond... (M03.002)	7836437,