TopFIND 4.0

P52888: Thimet oligopeptidase

General Information

Protein names
- Thimet oligopeptidase
- 3.4.24.15
- Endopeptidase 24.15
- MP78
Gene names THOP1
Organism Homo sapiens
Protease Family M03.001
Protease ID M03.001
Chromosome location
UniProt ID P52888

9

N-termini

6

C-termini

3

Cleavages

29

Substrates

Sequence

        10         20         30         40         50         60 
MKPPAACAGD MADAASPCSV VNDLRWDLSA QQIEERTREL IEQTKRVYDQ VGTQEFEDVS 
        70         80         90        100        110        120 
YESTLKALAD VEVTYTVQRN ILDFPQHVSP SKDIRTASTE ADKKLSEFDV EMSMREDVYQ 
       130        140        150        160        170        180 
RIVWLQEKVQ KDSLRPEAAR YLERLIKLGR RNGLHLPRET QENIKRIKKK LSLLCIDFNK 
       190        200        210        220        230        240 
NLNEDTTFLP FTLQELGGLP EDFLNSLEKM EDGKLKVTLK YPHYFPLLKK CHVPETRRKV 
       250        260        270        280        290        300 
EEAFNCRCKE ENCAILKELV TLRAQKSRLL GFHTHADYVL EMNMAKTSQT VATFLDELAQ 
       310        320        330        340        350        360 
KLKPLGEQER AVILELKRAE CERRGLPFDG RIRAWDMRYY MNQVEETRYC VDQNLLKEYF 
       370        380        390        400        410        420 
PVQVVTHGLL GIYQELLGLA FHHEEGASAW HEDVRLYTAR DAASGEVVGK FYLDLYPREG 
       430        440        450        460        470        480 
KYGHAACFGL QPGCLRQDGS RQIAIAAMVA NFTKPTADAP SLLQHDEVET YFHEFGHVMH 
       490        500        510        520        530        540 
QLCSQAEFAM FSGTHVERDF VEAPSQMLEN WVWEQEPLLR MSRHYRTGSA VPRELLEKLI 
       550        560        570        580        590        600 
ESRQANTGLF NLRQIVLAKV DQALHTQTDA DPAEEYARLC QEILGVPATP GTNMPATFGH 
       610        620        630        640        650        660 
LAGGYDAQYY GYLWSEVYSM DMFHTRFKQE GVLNSKVGMD YRSCILRPGG SEDASAMLRR 
       670        680    
FLGRDPKQDA FLLSKGLQVG GCEPEPQVC

Isoforms

- Isoform 2 of Thimet oligopeptidase

Sequence View

        10         20         30         40         50         60 
MKPPAACAGD MADAASPCSV VNDLRWDLSA QQIEERTREL IEQTKRVYDQ VGTQEFEDVS 
        70         80         90        100        110        120 
YESTLKALAD VEVTYTVQRN ILDFPQHVSP SKDIRTASTE ADKKLSEFDV EMSMREDVYQ 
       130        140        150        160        170        180 
RIVWLQEKVQ KDSLRPEAAR YLERLIKLGR RNGLHLPRET QENIKRIKKK LSLLCIDFNK 
       190        200        210        220        230        240 
NLNEDTTFLP FTLQELGGLP EDFLNSLEKM EDGKLKVTLK YPHYFPLLKK CHVPETRRKV 
       250        260        270        280        290        300 
EEAFNCRCKE ENCAILKELV TLRAQKSRLL GFHTHADYVL EMNMAKTSQT VATFLDELAQ 
       310        320        330        340        350        360 
KLKPLGEQER AVILELKRAE CERRGLPFDG RIRAWDMRYY MNQVEETRYC VDQNLLKEYF 
       370        380        390        400        410        420 
PVQVVTHGLL GIYQELLGLA FHHEEGASAW HEDVRLYTAR DAASGEVVGK FYLDLYPREG 
       430        440        450        460        470        480 
KYGHAACFGL QPGCLRQDGS RQIAIAAMVA NFTKPTADAP SLLQHDEVET YFHEFGHVMH 
       490        500        510        520        530        540 
QLCSQAEFAM FSGTHVERDF VEAPSQMLEN WVWEQEPLLR MSRHYRTGSA VPRELLEKLI 
       550        560        570        580        590        600 
ESRQANTGLF NLRQIVLAKV DQALHTQTDA DPAEEYARLC QEILGVPATP GTNMPATFGH 
       610        620        630        640        650        660 
LAGGYDAQYY GYLWSEVYSM DMFHTRFKQE GVLNSKVGMD YRSCILRPGG SEDASAMLRR 
       670        680    
FLGRDPKQDA FLLSKGLQVG GCEPEPQVC



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Protein Neighborhood

Domains & Features

9 N-termini - 6 C-termini - 3 Cleavages - 29 Substrates

N-termini

C-termini

Cleavages

Substrates