Q01959: Sodium-dependent dopamine transporter

General Information

Protein names	- Sodium-dependent dopamine transporter - DA transporter - DAT - Solute carrier family 6 member 3
Gene names	SLC6A3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q01959

4 N-termini

4 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSKSKCSVGL MSSVVAPAKE PNAVGPKEVE LILVKEQNGV QLTSSTLTNP RQSPVEAQDR
        70         80         90        100        110        120
ETWGKKIDFL LSVIGFAVDL ANVWRFPYLC YKNGGGAFLV PYLLFMVIAG MPLFYMELAL
       130        140        150        160        170        180
GQFNREGAAG VWKICPILKG VGFTVILISL YVGFFYNVII AWALHYLFSS FTTELPWIHC
       190        200        210        220        230        240
NNSWNSPNCS DAHPGDSSGD SSGLNDTFGT TPAAEYFERG VLHLHQSHGI DDLGPPRWQL
       250        260        270        280        290        300
TACLVLVIVL LYFSLWKGVK TSGKVVWITA TMPYVVLTAL LLRGVTLPGA IDGIRAYLSV
       310        320        330        340        350        360
DFYRLCEASV WIDAATQVCF SLGVGFGVLI AFSSYNKFTN NCYRDAIVTT SINSLTSFSS
       370        380        390        400        410        420
GFVVFSFLGY MAQKHSVPIG DVAKDGPGLI FIIYPEAIAT LPLSSAWAVV FFIMLLTLGI
       430        440        450        460        470        480
DSAMGGMESV ITGLIDEFQL LHRHRELFTL FIVLATFLLS LFCVTNGGIY VFTLLDHFAA
       490        500        510        520        530        540
GTSILFGVLI EAIGVAWFYG VGQFSDDIQQ MTGQRPSLYW RLCWKLVSPC FLLFVVVVSI
       550        560        570        580        590        600
VTFRPPHYGA YIFPDWANAL GWVIATSSMA MVPIYAAYKF CSLPGSFREK LAYAIAPEKD
       610        620
RELVDRGEVR QFTLRHWLKV

Isoforms

Sequence View

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q01959-1-unknown	MSKSKC...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q01959-44-unknown	SSTLTN...	44	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1060
Q01959-72-unknown	SVIGFA...	72	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1061
Q01959-75-unknown	GFAVDL...	75	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429101

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GVQLTS	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1060
...IDFLLS	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1061
...NNCYRD	344	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429101
...HWLKV	620	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CAN2_HUMAN	43	QLTS.\|.SSTL	inferred from experiment	unknown	MEROPS	Jursky F	Franekova V et al.:Truncation of human dopamine tr... (C02.002)	18468730,
CAN2_HUMAN	71	FLLS.\|.SVIG	inferred from experiment	unknown	MEROPS	Jursky F	Franekova V et al.:Truncation of human dopamine tr... (C02.002)	18468730,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

TopFIND

Q01959: Sodium-dependent dopamine transporter

General Information

4

N-termini

4

C-termini

2

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 2 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates