P30301: Lens fiber major intrinsic protein
| Protein names | - Lens fiber major intrinsic protein - Aquaporin-0 - MIP26 - MP26 |
|---|---|
| Gene names | MIP |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | P30301 |
3
N-termini
5
C-termini
4
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MWELRSASFW RAIFAEFFAT LFYVFFGLGS SLRWAPGPLH VLQVAMAFGL ALATLVQSVG
70 80 90 100 110 120
HISGAHVNPA VTFAFLVGSQ MSLLRAFCYM AAQLLGAVAG AAVLYSVTPP AVRGNLALNT
130 140 150 160 170 180
LHPAVSVGQA TTVEIFLTLQ FVLCIFATYD ERRNGQLGSV ALAVGFSLAL GHLFGMYYTG
190 200 210 220 230 240
AGMNPARSFA PAILTGNFTN HWVYWVGPII GGGLGSLLYD FLLFPRLKSI SERLSVLKGA
250 260
KPDVSNGQPE VTGEPVELNT QAL
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
3 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P30301-1-unknown | MWELRS... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P30301-239-unknown | GAKPDV... | 239 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1009 | |||
| P30301-253-unknown | GEPVEL... | 253 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1010 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...LSVLKG | 238 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1009 | |||
| ...QPEVTG | 252 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1010 | |||
| ...PVELNT | 259 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1011 | |||
| ...VELNTQ | 260 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC1012 | |||
| ...NTQAL | 263 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| CAN2_HUMAN | 238 | VLKG.|.GAKP | inferred from experiment | unknown | MEROPS | Shearer TR | Ma H et al.:Degradation of human aquaporin ... (C02.002) | 16310784, |
| CAN2_HUMAN | 252 | EVTG.|.GEPV | inferred from experiment | unknown | MEROPS | Shearer TR | Ma H et al.:Degradation of human aquaporin ... (C02.002) | 16310784, |
| CAN2_HUMAN | 259 | ELNT.|.TQAL | inferred from experiment | unknown | MEROPS | Shearer TR | Ma H et al.:Degradation of human aquaporin ... (C02.002) | 16310784, |
| CAN2_HUMAN | 260 | LNTQ.|.QAL | inferred from experiment | unknown | MEROPS | Shearer TR | Ma H et al.:Degradation of human aquaporin ... (C02.002) | 16310784, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|