P00533: Epidermal growth factor receptor

General Information

Protein names	- Epidermal growth factor receptor - 2.7.10.1 - Proto-oncogene c-ErbB-1 - Receptor tyrosine-protein kinase erbB-1
Gene names	EGFR
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P00533

11 N-termini

11 C-termini

9 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Epidermal growth factor receptor - Isoform 3 of Epidermal growth factor receptor - Isoform 4 of Epidermal growth factor receptor

Sequence View

        10         20         30         40         50         60
MRPSGTAGAA LLALLAALCP ASRALEEKKV CQGTSNKLTQ LGTFEDHFLS LQRMFNNCEV
        70         80         90        100        110        120
VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN MYYENSYALA
       130        140        150        160        170        180
VLSNYDANKT GLKELPMRNL QEILHGAVRF SNNPALCNVE SIQWRDIVSS DFLSNMSMDF
       190        200        210        220        230        240
QNHLGSCQKC DPSCPNGSCW GAGEENCQKL TKIICAQQCS GRCRGKSPSD CCHNQCAAGC
       250        260        270        280        290        300
TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV
       310        320        330        340        350        360
VTDHGSCVRA CGADSYEMEE DGVRKCKKCE GPCRKVCNGI GIGEFKDSLS INATNIKHFK
       370        380        390        400        410        420
NCTSISGDLH ILPVAFRGDS FTHTPPLDPQ ELDILKTVKE ITGFLLIQAW PENRTDLHAF
       430        440        450        460        470        480
ENLEIIRGRT KQHGQFSLAV VSLNITSLGL RSLKEISDGD VIISGNKNLC YANTINWKKL
       490        500        510        520        530        540
FGTSGQKTKI ISNRGENSCK ATGQVCHALC SPEGCWGPEP RDCVSCRNVS RGRECVDKCN
       550        560        570        580        590        600
LLEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGVM
       610        620        630        640        650        660
GENNTLVWKY ADAGHVCHLC HPNCTYGCTG PGLEGCPTNG PKIPSIATGM VGALLLLLVV
       670        680        690        700        710        720
ALGIGLFMRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKIKVLGS
       730        740        750        760        770        780
GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI
       790        800        810        820        830        840
CLTSTVQLIT QLMPFGCLLD YVREHKDNIG SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA
       850        860        870        880        890        900
RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY
       910        920        930        940        950        960
GVTVWELMTF GSKPYDGIPA SEISSILEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK
       970        980        990       1000       1010       1020
FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA LMDEEDMDDV VDADEYLIPQ
      1030       1040       1050       1060       1070       1080
QGFFSSPSTS RTPLLSSLSA TSNNSTVACI DRNGLQSCPI KEDSFLQRYS SDPTGALTED
      1090       1100       1110       1120       1130       1140
SIDDTFLPVP EYINQSVPKR PAGSVQNPVY HNQPLNPAPS RDPHYQDPHS TAVGNPEYLN
      1150       1160       1170       1180       1190       1200
TVQPTCVNST FDSPAHWAQK GSHQISLDNP DYQQDFFPKE AKPNGIFKGS TAENAEYLRV
      1210
APQSSEFIGA         10         20         30         40         50         60
MRPSGTAGAA LLALLAALCP ASRALEEKKV CQGTSNKLTQ LGTFEDHFLS LQRMFNNCEV
        70         80         90        100        110        120
VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN MYYENSYALA
       130        140        150        160        170        180
VLSNYDANKT GLKELPMRNL QEILHGAVRF SNNPALCNVE SIQWRDIVSS DFLSNMSMDF
       190        200        210        220        230        240
QNHLGSCQKC DPSCPNGSCW GAGEENCQKL TKIICAQQCS GRCRGKSPSD CCHNQCAAGC
       250        260        270        280        290        300
TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV
       310        320        330        340        350        360
VTDHGSCVRA CGADSYEMEE DGVRKCKKCE GPCRKVCNGI GIGEFKDSLS INATNIKHFK
       370        380        390        400        410        420
NCTSISGDLH ILPVAFRGDS FTHTPPLDPQ ELDILKTVKE ITGFLLIQAW PENRTDLHAF
       430        440        450        460        470        480
ENLEIIRGRT KQHGQFSLAV VSLNITSLGL RSLKEISDGD VIISGNKNLC YANTINWKKL
       490        500        510        520        530        540
FGTSGQKTKI ISNRGENSCK ATGQVCHALC SPEGCWGPEP RDCVSCRNVS RGRECVDKCN
       550        560        570        580        590        600
LLEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGVM
       610        620        630        640        650        660
GENNTLVWKY ADAGHVCHLC HPNCTYGCTG PGLEGCPTNG PKIPSIATGM VGALLLLLVV
       670        680        690        700        710        720
ALGIGLFMRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKIKVLGS
       730        740        750        760        770        780
GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI
       790        800        810        820        830        840
CLTSTVQLIT QLMPFGCLLD YVREHKDNIG SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA
       850        860        870        880        890        900
RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY
       910        920        930        940        950        960
GVTVWELMTF GSKPYDGIPA SEISSILEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK
       970        980        990       1000       1010       1020
FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA LMDEEDMDDV VDADEYLIPQ
      1030       1040       1050       1060       1070       1080
QGFFSSPSTS RTPLLSSLSA TSNNSTVACI DRNGLQSCPI KEDSFLQRYS SDPTGALTED
      1090       1100       1110       1120       1130       1140
SIDDTFLPVP EYINQSVPKR PAGSVQNPVY HNQPLNPAPS RDPHYQDPHS TAVGNPEYLN
      1150       1160       1170       1180       1190       1200
TVQPTCVNST FDSPAHWAQK GSHQISLDNP DYQQDFFPKE AKPNGIFKGS TAENAEYLRV
      1210
APQSSEFIGA         10         20         30         40         50         60
MRPSGTAGAA LLALLAALCP ASRALEEKKV CQGTSNKLTQ LGTFEDHFLS LQRMFNNCEV
        70         80         90        100        110        120
VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN MYYENSYALA
       130        140        150        160        170        180
VLSNYDANKT GLKELPMRNL QEILHGAVRF SNNPALCNVE SIQWRDIVSS DFLSNMSMDF
       190        200        210        220        230        240
QNHLGSCQKC DPSCPNGSCW GAGEENCQKL TKIICAQQCS GRCRGKSPSD CCHNQCAAGC
       250        260        270        280        290        300
TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV
       310        320        330        340        350        360
VTDHGSCVRA CGADSYEMEE DGVRKCKKCE GPCRKVCNGI GIGEFKDSLS INATNIKHFK
       370        380        390        400        410        420
NCTSISGDLH ILPVAFRGDS FTHTPPLDPQ ELDILKTVKE ITGFLLIQAW PENRTDLHAF
       430        440        450        460        470        480
ENLEIIRGRT KQHGQFSLAV VSLNITSLGL RSLKEISDGD VIISGNKNLC YANTINWKKL
       490        500        510        520        530        540
FGTSGQKTKI ISNRGENSCK ATGQVCHALC SPEGCWGPEP RDCVSCRNVS RGRECVDKCN
       550        560        570        580        590        600
LLEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGVM
       610        620        630        640        650        660
GENNTLVWKY ADAGHVCHLC HPNCTYGCTG PGLEGCPTNG PKIPSIATGM VGALLLLLVV
       670        680        690        700        710        720
ALGIGLFMRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKIKVLGS
       730        740        750        760        770        780
GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI
       790        800        810        820        830        840
CLTSTVQLIT QLMPFGCLLD YVREHKDNIG SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA
       850        860        870        880        890        900
RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY
       910        920        930        940        950        960
GVTVWELMTF GSKPYDGIPA SEISSILEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK
       970        980        990       1000       1010       1020
FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA LMDEEDMDDV VDADEYLIPQ
      1030       1040       1050       1060       1070       1080
QGFFSSPSTS RTPLLSSLSA TSNNSTVACI DRNGLQSCPI KEDSFLQRYS SDPTGALTED
      1090       1100       1110       1120       1130       1140
SIDDTFLPVP EYINQSVPKR PAGSVQNPVY HNQPLNPAPS RDPHYQDPHS TAVGNPEYLN
      1150       1160       1170       1180       1190       1200
TVQPTCVNST FDSPAHWAQK GSHQISLDNP DYQQDFFPKE AKPNGIFKGS TAENAEYLRV
      1210
APQSSEFIGA

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 11 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P00533-1-unknown	MRPSGT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73723
P00533-1-unknown	MRPSGT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73724
P00533-1-unknown	MRPSGT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt73725
P00533-25-unknown	LEEKKV...	25	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P00533-25-unknown	LEEKKV...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113790
P00533-25-unknown	LEEKKV...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113791
P00533-25-unknown	LEEKKV...	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt113792
P00533-684-unknown	QERELV...	684	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC854
P00533-734-unknown	EGEKVK...	734	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC855
P00533-1007-unknown	MDDVVD...	1007	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1515
P00533-1010-unknown	VVDADE...	1010	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1516
P00533-1031-unknown	RTPLLS...	1031	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC856
P00533-1060-unknown	IKEDSF...	1060	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC857
P00533-1087-unknown	LPVPEY...	1087	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC858
P00533-1152-unknown	DSPAHW...	1152	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC859
P00533-1186-unknown	IFKGST...	1186	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC860

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LRRLLQ	683	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC854
...GLWIPE	733	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC855
...MDEEDM	1006	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1515
...EDMDDV	1009	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1516
...SPSTSR	1030	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC856
...LQSCPI	1059	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC857
...IDDTFL	1086	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC858
...VNSTFD	1151	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC859
...AKPNGI	1185	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC860
...EFIGA	1210	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...EFIGA	1210		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...EFIGA	1210		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CAN2_HUMAN	683	RLLQ.\|.QERE	inferred from experiment	unknown	MEROPS	Crawford C	Gregoriou M et al.:The calpain cleavage sites in t... (C02.002)	8055914,
CAN2_HUMAN	733	WIPE.\|.EGEK	inferred from experiment	unknown	MEROPS	Crawford C	Gregoriou M et al.:The calpain cleavage sites in t... (C02.002)	8055914,
CASP3_HUMAN	1006	EEDM.\|.MDDV	inferred from experiment	unknown	MEROPS	Suh PG	Bae SS et al.:Proteolytic cleavage of epiderm... (C14.003)	11226410,
CASP3_HUMAN	1009	MDDV.\|.VVDA	inferred from experiment	unknown	MEROPS	Suh PG	Bae SS et al.:Proteolytic cleavage of epiderm... (C14.003)	11226410,
CAN2_HUMAN	1030	STSR.\|.RTPL	inferred from experiment	unknown	MEROPS	Crawford C	Gregoriou M et al.:The calpain cleavage sites in t... (C02.002)	8055914,
CAN2_HUMAN	1059	SCPI.\|.IKED	inferred from experiment	unknown	MEROPS	Crawford C	Gregoriou M et al.:The calpain cleavage sites in t... (C02.002)	8055914,
CAN2_HUMAN	1086	DTFL.\|.LPVP	inferred from experiment	unknown	MEROPS	Crawford C	Gregoriou M et al.:The calpain cleavage sites in t... (C02.002)	8055914,
CAN2_HUMAN	1151	STFD.\|.DSPA	inferred from experiment	unknown	MEROPS	Crawford C	Gregoriou M et al.:The calpain cleavage sites in t... (C02.002)	8055914,
CAN2_HUMAN	1185	PNGI.\|.IFKG	inferred from experiment	unknown	MEROPS	Crawford C	Gregoriou M et al.:The calpain cleavage sites in t... (C02.002)	8055914,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)