P05107: Integrin beta-2

General Information

Protein names	- Integrin beta-2 - Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta - Complement receptor C3 subunit beta - CD18
Gene names	ITGB2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P05107

5 N-termini

16 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLGLRPPLLA LVGLLSLGCV LSQECTKFKV SSCRECIESG PGCTWCQKLN FTGPGDPDSI
        70         80         90        100        110        120
RCDTRPQLLM RGCAADDIMD PTSLAETQED HNGGQKQLSP QKVTLYLRPG QAAAFNVTFR
       130        140        150        160        170        180
RAKGYPIDLY YLMDLSYSML DDLRNVKKLG GDLLRALNEI TESGRIGFGS FVDKTVLPFV
       190        200        210        220        230        240
NTHPDKLRNP CPNKEKECQP PFAFRHVLKL TNNSNQFQTE VGKQLISGNL DAPEGGLDAM
       250        260        270        280        290        300
MQVAACPEEI GWRNVTRLLV FATDDGFHFA GDGKLGAILT PNDGRCHLED NLYKRSNEFD
       310        320        330        340        350        360
YPSVGQLAHK LAENNIQPIF AVTSRMVKTY EKLTEIIPKS AVGELSEDSS NVVQLIKNAY
       370        380        390        400        410        420
NKLSSRVFLD HNALPDTLKV TYDSFCSNGV THRNQPRGDC DGVQINVPIT FQVKVTATEC
       430        440        450        460        470        480
IQEQSFVIRA LGFTDIVTVQ VLPQCECRCR DQSRDRSLCH GKGFLECGIC RCDTGYIGKN
       490        500        510        520        530        540
CECQTQGRSS QELEGSCRKD NNSIICSGLG DCVCGQCLCH TSDVPGKLIY GQYCECDTIN
       550        560        570        580        590        600
CERYNGQVCG GPGRGLCFCG KCRCHPGFEG SACQCERTTE GCLNPRRVEC SGRGRCRCNV
       610        620        630        640        650        660
CECHSGYQLP LCQECPGCPS PCGKYISCAE CLKFEKGPFG KNCSAACPGL QLSNNPVKGR
       670        680        690        700        710        720
TCKERDSEGC WVAYTLEQQD GMDRYLIYVD ESRECVAGPN IAAIVGGTVA GIVLIGILLL
       730        740        750        760
VIWKALIHLS DLREYRRFEK EKLKSQWNND NPLFKSATTT VMNPKFAES

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

5 N-termini - 16 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P05107-23-unknown	QECTKF...	23	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P05107-70-unknown	MRGCAA...	70	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428125
P05107-70-unknown	MRGCAA...	70	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000430901
P05107-745-unknown	SQWNND...	745	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC924
P05107-755-unknown	KSATTT...	755	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC925
P05107-763-unknown	NPKFAE...	763	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC926

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...WCQKLN	49	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000429683
...PQLLMR	70	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428870
...KVTLYL	106	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000430901
...AFNVTF	118	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428125
...NVTFRR	120	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428413
...ALNEIT	160	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428979
...ESGRIG	166	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000428503
...VKTYEK	331	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000317697
...KEKLKS	744	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC924
...DNPLFK	754	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC925
...TTTVMN	762	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC926
...VMNPKF	765	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8169
...MNPKFA	766	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8170
...NPKFAE	767	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8171
...PKFAES	768	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8172
...KFAES	769	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CAN2_HUMAN	744	KLKS.\|.SQWN	inferred from experiment	unknown	MEROPS	Ginsberg MH	Pfaff M et al.:Calpain cleavage of integrin be... (C02.002)	10571053,
CAN2_HUMAN	754	PLFK.\|.KSAT	inferred from experiment	unknown	MEROPS	Ginsberg MH	Pfaff M et al.:Calpain cleavage of integrin be... (C02.002)	10571053,
CAN2_HUMAN	762	TVMN.\|.NPKF	inferred from experiment	unknown	MEROPS	Ginsberg MH	Pfaff M et al.:Calpain cleavage of integrin be... (C02.002)	10571053,
CATZ_HUMAN	765	NPKF.\|.FAES	inferred from experiment	unknown	MEROPS	Kos J	Obermajer N et al.:Maturation of dendritic cells d... (C01.013)	18701767,
CATZ_HUMAN	766	PKFA.\|.AES	inferred from experiment	unknown	MEROPS	Kos J	Obermajer N et al.:Maturation of dendritic cells d... (C01.013)	18701767,
CATZ_HUMAN	767	KFAE.\|.ES	inferred from experiment	unknown	MEROPS	Kos J	Obermajer N et al.:Maturation of dendritic cells d... (C01.013)	18701767,
CATZ_HUMAN	768	FAES.\|.S	inferred from experiment	unknown	MEROPS	Kos J	Obermajer N et al.:Maturation of dendritic cells d... (C01.013)	18701767,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)