Q9UBR2: Cathepsin Z
Protein names | - Cathepsin Z - 3.4.18.1 {ECO:0000269|PubMed:10504234} - Cathepsin P - Cathepsin X |
---|---|
Gene names | CTSZ |
Organism | Homo sapiens |
Protease Family | C01.013 |
Protease ID | C01.013 |
Chromosome location | |
UniProt ID | Q9UBR2 |
3
N-termini
1
C-termini
0
Cleavages
47
Substrates
Sequence
10 20 30 40 50 60
MARRGPGWRP LLLLVLLAGA AQGGLYFRRG QTCYRPLRGD GLAPLGRSTY PRPHEYLSPA
70 80 90 100 110 120
DLPKSWDWRN VDGVNYASIT RNQHIPQYCG SCWAHASTSA MADRINIKRK GAWPSTLLSV
130 140 150 160 170 180
QNVIDCGNAG SCEGGNDLSV WDYAHQHGIP DETCNNYQAK DQECDKFNQC GTCNEFKECH
190 200 210 220 230 240
AIRNYTLWRV GDYGSLSGRE KMMAEIYANG PISCGIMATE RLANYTGGIY AEYQDTTYIN
250 260 270 280 290 300
HVVSVAGWGI SDGTEYWIVR NSWGEPWGER GWLRIVTSTY KDGKGARYNL AIEEHCTFGD
PIV
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
3 N-termini - 1 C-termini - 0 Cleavages - 47 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q9UBR2-24-unknown | GLYFRR... | 24 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q9UBR2-62-unknown | LPKSWD... | 62 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q9UBR2-70- | NVDGVN... | 70 | Subtiligase Based Positive Selection | Wells | apoptosis_U266_bortezomib_induced | 23264352 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...GDPIV | 303 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
SDF1-Isoform6_HUMAN | 75 | DPKL.|.LKWI | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8182 | ||
SDF1-Isoform5_HUMAN | 75 | DPKL.|.LKWI | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8182 | ||
SDF1-Isoform4_HUMAN | 75 | DPKL.|.LKWI | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8182 | ||
SDF1-Isoform3_HUMAN | 75 | DPKL.|.LKWI | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8182 | ||
SDF1-Isoform2_HUMAN | 75 | DPKL.|.LKWI | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8182 | ||
SDF1_HUMAN | 75 | DPKL.|.LKWI | inferred from experiment | unknown | MEROPS | Klein G | Staudt ND et al.:Cathepsin X is secreted by huma... (C01.013) | 20494937, |
SDF1-Isoform6_HUMAN | 76 | PKLK.|.KWIQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8188 | ||
SDF1-Isoform5_HUMAN | 76 | PKLK.|.KWIQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8188 | ||
SDF1-Isoform4_HUMAN | 76 | PKLK.|.KWIQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8188 | ||
SDF1-Isoform3_HUMAN | 76 | PKLK.|.KWIQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8188 | ||
SDF1-Isoform2_HUMAN | 76 | PKLK.|.KWIQ | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8188 | ||
SDF1_HUMAN | 76 | PKLK.|.KWIQ | inferred from experiment | unknown | MEROPS | Klein G | Staudt ND et al.:Cathepsin X is secreted by huma... (C01.013) | 20494937, |
SDF1-Isoform6_HUMAN | 77 | KLKW.|.WIQE | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8194 | ||
SDF1-Isoform5_HUMAN | 77 | KLKW.|.WIQE | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8194 | ||
SDF1-Isoform4_HUMAN | 77 | KLKW.|.WIQE | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8194 | ||
SDF1-Isoform3_HUMAN | 77 | KLKW.|.WIQE | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8194 | ||
SDF1-Isoform2_HUMAN | 77 | KLKW.|.WIQE | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8194 | ||
SDF1_HUMAN | 77 | KLKW.|.WIQE | inferred from experiment | unknown | MEROPS | Klein G | Staudt ND et al.:Cathepsin X is secreted by huma... (C01.013) | 20494937, |
SDF1-Isoform6_HUMAN | 78 | LKWI.|.IQEY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8200 | ||
SDF1-Isoform5_HUMAN | 78 | LKWI.|.IQEY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8200 | ||
SDF1-Isoform4_HUMAN | 78 | LKWI.|.IQEY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8200 | ||
SDF1-Isoform3_HUMAN | 78 | LKWI.|.IQEY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8200 | ||
SDF1-Isoform2_HUMAN | 78 | LKWI.|.IQEY | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8200 | ||
SDF1_HUMAN | 78 | LKWI.|.IQEY | inferred from experiment | unknown | MEROPS | Klein G | Staudt ND et al.:Cathepsin X is secreted by huma... (C01.013) | 20494937, |
SDF1-Isoform6_HUMAN | 79 | KWIQ.|.QEYL | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8206 | ||
SDF1-Isoform3_HUMAN | 79 | KWIQ.|.QEYL | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8206 | ||
SDF1-Isoform2_HUMAN | 79 | KWIQ.|.QEYL | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8206 | ||
SDF1_HUMAN | 79 | KWIQ.|.QEYL | inferred from experiment | unknown | MEROPS | Klein G | Staudt ND et al.:Cathepsin X is secreted by huma... (C01.013) | 20494937, |
SDF1_HUMAN | 80 | WIQE.|.EYLE | inferred from experiment | unknown | MEROPS | Klein G | Staudt ND et al.:Cathepsin X is secreted by huma... (C01.013) | 20494937, |
SDF1_HUMAN | 81 | IQEY.|.YLEK | inferred from experiment | unknown | MEROPS | Klein G | Staudt ND et al.:Cathepsin X is secreted by huma... (C01.013) | 20494937, |
SDF1_HUMAN | 82 | QEYL.|.LEKA | inferred from experiment | unknown | MEROPS | Klein G | Staudt ND et al.:Cathepsin X is secreted by huma... (C01.013) | 20494937, |
SDF1_HUMAN | 83 | EYLE.|.EKAL | inferred from experiment | unknown | MEROPS | Klein G | Staudt ND et al.:Cathepsin X is secreted by huma... (C01.013) | 20494937, |
SDF1_HUMAN | 84 | YLEK.|.KALN | inferred from experiment | unknown | MEROPS | Klein G | Staudt ND et al.:Cathepsin X is secreted by huma... (C01.013) | 20494937, |
SDF1_HUMAN | 85 | LEKA.|.ALNK | inferred from experiment | unknown | MEROPS | Klein G | Staudt ND et al.:Cathepsin X is secreted by huma... (C01.013) | 20494937, |
SDF1_HUMAN | 86 | EKAL.|.LNKR | inferred from experiment | unknown | MEROPS | Klein G | Staudt ND et al.:Cathepsin X is secreted by huma... (C01.013) | 20494937, |
SDF1_HUMAN | 87 | KALN.|.NKRF | inferred from experiment | unknown | MEROPS | Klein G | Staudt ND et al.:Cathepsin X is secreted by huma... (C01.013) | 20494937, |
SDF1_HUMAN | 88 | ALNK.|.KRFK | inferred from experiment | unknown | MEROPS | Klein G | Staudt ND et al.:Cathepsin X is secreted by huma... (C01.013) | 20494937, |
ENOA-Isoform2_HUMAN | 339 | NPLA.|.AK | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8173 | ||
ENOA-Isoform2_HUMAN | 340 | PLAK.|.K | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC8175 | ||
ENOA_HUMAN | 432 | NPLA.|.AK | inferred from experiment | unknown | MEROPS | Kos J | Obermajer N et al.:Cathepsin X cleaves the C-termi... (C01.013) | 19433310, |
ENOG_HUMAN | 432 | NPSV.|.VL | inferred from experiment | unknown | MEROPS | Kos J | Obermajer N et al.:Cathepsin X cleaves the C-termi... (C01.013) | 19433310, |
ENOA_HUMAN | 433 | PLAK.|.K | inferred from experiment | unknown | MEROPS | Kos J | Obermajer N et al.:Cathepsin X cleaves the C-termi... (C01.013) | 19433310, |
ENOG_HUMAN | 433 | PSVL.|.L | inferred from experiment | unknown | MEROPS | Kos J | Obermajer N et al.:Cathepsin X cleaves the C-termi... (C01.013) | 19433310, |
ITB2_HUMAN | 765 | NPKF.|.FAES | inferred from experiment | unknown | MEROPS | Kos J | Obermajer N et al.:Maturation of dendritic cells d... (C01.013) | 18701767, |
ITB2_HUMAN | 766 | PKFA.|.AES | inferred from experiment | unknown | MEROPS | Kos J | Obermajer N et al.:Maturation of dendritic cells d... (C01.013) | 18701767, |
ITB2_HUMAN | 767 | KFAE.|.ES | inferred from experiment | unknown | MEROPS | Kos J | Obermajer N et al.:Maturation of dendritic cells d... (C01.013) | 18701767, |
ITB2_HUMAN | 768 | FAES.|.S | inferred from experiment | unknown | MEROPS | Kos J | Obermajer N et al.:Maturation of dendritic cells d... (C01.013) | 18701767, |