P09104: Gamma-enolase

General Information

Protein names	- Gamma-enolase - 4.2.1.11 - 2-phospho-D-glycerate hydro-lyase - Enolase 2 - Neural enolase - Neuron-specific enolase - NSE
Gene names	ENO2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P09104

9 N-termini

11 C-termini

11 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSIEKIWARE ILDSRGNPTV EVDLYTAKGL FRAAVPSGAS TGIYEALELR DGDKQRYLGK
        70         80         90        100        110        120
GVLKAVDHIN STIAPALISS GLSVVEQEKL DNLMLELDGT ENKSKFGANA ILGVSLAVCK
       130        140        150        160        170        180
AGAAERELPL YRHIAQLAGN SDLILPVPAF NVINGGSHAG NKLAMQEFMI LPVGAESFRD
       190        200        210        220        230        240
AMRLGAEVYH TLKGVIKDKY GKDATNVGDE GGFAPNILEN SEALELVKEA IDKAGYTEKI
       250        260        270        280        290        300
VIGMDVAASE FYRDGKYDLD FKSPTDPSRY ITGDQLGALY QDFVRDYPVV SIEDPFDQDD
       310        320        330        340        350        360
WAAWSKFTAN VGIQIVGDDL TVTNPKRIER AVEEKACNCL LLKVNQIGSV TEAIQACKLA
       370        380        390        400        410        420
QENGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR SERLAKYNQL MRIEEELGDE
       430
ARFAGHNFRN PSVL

Isoforms

- Isoform 2 of Gamma-enolase

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 11 C-termini - 11 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P09104-1-unknown	MSIEKI...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P09104-2-acetylation	SIEKIW...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P09104-2-acetylation	SIEKIW...	2	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P09104-2-acetylation	SIEKIW...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P09104-39-unknown	ASTGIY...	39		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7257
P09104-110-unknown	AILGVS...	110		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5512
P09104-151-unknown	NVINGG...	151		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17237
P09104-152-unknown	VINGGS...	152		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC7258
P09104-152-unknown	VINGGS...	152		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5513
P09104-318-unknown	DDLTVT...	318		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17238
P09104-318-unknown	DDLTVT...	318		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18610
P09104-383-unknown	DLVVGL...	383		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18611
P09104-385-unknown	VVGLCT...	385		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC3546

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AVPSGA	38	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7257
...GTENKS	103	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000470907
...GTENKS	103	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000445788
...KFGANA	109	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5512
...PVPAFN	150	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17237
...VPAFNV	151	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC7258
...VPAFNV	151	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5513
...IQIVGD	317	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC17238
...IQIVGD	317	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18610
...DTFIAD	382	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC18611
...FIADLV	384	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC3546
...FRNPSV	432	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8177
...RNPSVL	433	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8178
...NPSVL	434	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATS_HUMAN	38	PSGA.\|.ASTG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	109	GANA.\|.AILG	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	150	PAFN.\|.NVIN	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATS_HUMAN	151	AFNV.\|.VING	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATL1_HUMAN	151	AFNV.\|.VING	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
MEP1A_HUMAN	317	IVGD.\|.DDLT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	317	IVGD.\|.DDLT	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1B_HUMAN	382	FIAD.\|.DLVV	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CATB_HUMAN	384	ADLV.\|.VVGL	inferred from experiment	unknown	MEROPS	Schilling O	Biniossek ML et al.:Proteomic identification of pro... (C01.060)	21967108,
CATZ_HUMAN	432	NPSV.\|.VL	inferred from experiment	unknown	MEROPS	Kos J	Obermajer N et al.:Cathepsin X cleaves the C-termi... (C01.013)	19433310,
CATZ_HUMAN	433	PSVL.\|.L	inferred from experiment	unknown	MEROPS	Kos J	Obermajer N et al.:Cathepsin X cleaves the C-termi... (C01.013)	19433310,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)