P49418: Amphiphysin

General Information

Protein names	- Amphiphysin
Gene names	AMPH
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P49418

10 N-termini

10 C-termini

9 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADIKTGIFA KNVQKRLNRA QEKVLQKLGK ADETKDEQFE EYVQNFKRQE AEGTRLQREL
        70         80         90        100        110        120
RGYLAAIKGM QEASMKLTES LHEVYEPDWY GREDVKMVGE KCDVLWEDFH QKLVDGSLLT
       130        140        150        160        170        180
LDTYLGQFPD IKNRIAKRSR KLVDYDSARH HLEALQSSKR KDESRISKAE EEFQKAQKVF
       190        200        210        220        230        240
EEFNVDLQEE LPSLWSRRVG FYVNTFKNVS SLEAKFHKEI AVLCHKLYEV MTKLGDQHAD
       250        260        270        280        290        300
KAFTIQGAPS DSGPLRIAKT PSPPEEPSPL PSPTASPNHT LAPASPAPAR PRSPSQTRKG
       310        320        330        340        350        360
PPVPPLPKVT PTKELQQENI ISFFEDNFVP EISVTTPSQN EVPEVKKEET LLDLDFDPFK
       370        380        390        400        410        420
PEVTPAGSAG VTHSPMSQTL PWDLWTTSTD LVQPASGGSF NGFTQPQDTS LFTMQTDQSM
       430        440        450        460        470        480
ICNLAESEQA PPTEPKAEEP LAAVTPAVGL DLGMDTRAEE PVEEAVIIPG ADADAAVGTL
       490        500        510        520        530        540
VSAAEGAPGE EAEAEKATVP AGEGVSLEEA KIGTETTEGA ESAQPEAEEL EATVPQEKVI
       550        560        570        580        590        600
PSVVIEPASN HEEEGENEIT IGAEPKETTE DAAPPGPTSE TPELATEQKP IQDPQPTPSA
       610        620        630        640        650        660
PAMGAADQLA SAREASQELP PGFLYKVETL HDFEAANSDE LTLQRGDVVL VVPSDSEADQ
       670        680        690
DAGWLVGVKE SDWLQYRDLA TYKGLFPENF TRRLD

Isoforms

- Isoform 2 of Amphiphysin

Sequence View

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

10 N-termini - 10 C-termini - 9 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P49418-1-unknown	MADIKT...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P49418-1-unknown	MADIKT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66822
P49418-334-unknown	VTTPSQ...	334	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1032
P49418-334-unknown	VTTPSQ...	334	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150595
P49418-378-unknown	QTLPWD...	378	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1034
P49418-378-unknown	QTLPWD...	378	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151567
P49418-393-unknown	QPASGG...	393	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1036
P49418-393-unknown	QPASGG...	393	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151888
P49418-455-unknown	DTRAEE...	455	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1038
P49418-479-unknown	TLVSAA...	479	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1039
P49418-479-unknown	TLVSAA...	479	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt152580
P49418-528-unknown	EELEAT...	528	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1041
P49418-528-unknown	EELEAT...	528	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153259
P49418-532-unknown	ATVPQE...	532	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1043
P49418-532-unknown	ATVPQE...	532	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt153303
P49418-594-unknown	PQPTPS...	594	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1045
P49418-594-unknown	PQPTPS...	594	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154001
P49418-610-unknown	ASAREA...	610	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1047
P49418-610-unknown	ASAREA...	610	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154196

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VPEISV	333	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1032
...VPEISV	333	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133992
...HSPMSQ	377	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1034
...HSPMSQ	377	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134972
...STDLVQ	392	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1036
...STDLVQ	392	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135293
...LDLGMD	454	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1038
...DAAVGT	478	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1039
...AQPEAE	527	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1041
...AQPEAE	527	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136683
...AEELEA	531	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1043
...AEELEA	531	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136727
...KPIQDP	593	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1045
...KPIQDP	593	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137421
...AADQLA	609	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1047
...AADQLA	609	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt137616
...TRRLD	695	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TRRLD	695	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62440

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CAN2_HUMAN	333	EISV.\|.VTTP	inferred from experiment	unknown	MEROPS	Tomizawa K	Wu Y et al.:Truncations of amphiphysin I by... (C02.002)	17541403,
CAN2_HUMAN	377	PMSQ.\|.QTLP	inferred from experiment	unknown	MEROPS	Tomizawa K	Wu Y et al.:Truncations of amphiphysin I by... (C02.002)	17541403,
CAN2_HUMAN	392	DLVQ.\|.QPAS	inferred from experiment	unknown	MEROPS	Tomizawa K	Wu Y et al.:Truncations of amphiphysin I by... (C02.002)	17541403,
CAN2_HUMAN	454	LGMD.\|.DTRA	inferred from experiment	unknown	MEROPS	Tomizawa K	Wu Y et al.:Truncations of amphiphysin I by... (C02.002)	17541403,
CAN2_HUMAN	478	AVGT.\|.TLVS	inferred from experiment	unknown	MEROPS	Tomizawa K	Wu Y et al.:Truncations of amphiphysin I by... (C02.002)	17541403,
CAN2_HUMAN	527	PEAE.\|.EELE	inferred from experiment	unknown	MEROPS	Tomizawa K	Wu Y et al.:Truncations of amphiphysin I by... (C02.002)	17541403,
CAN2_HUMAN	531	ELEA.\|.ATVP	inferred from experiment	unknown	MEROPS	Tomizawa K	Wu Y et al.:Truncations of amphiphysin I by... (C02.002)	17541403,
CAN2_HUMAN	593	IQDP.\|.PQPT	inferred from experiment	unknown	MEROPS	Tomizawa K	Wu Y et al.:Truncations of amphiphysin I by... (C02.002)	17541403,
CAN2_HUMAN	609	DQLA.\|.ASAR	inferred from experiment	unknown	MEROPS	Tomizawa K	Wu Y et al.:Truncations of amphiphysin I by... (C02.002)	17541403,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)