O43847: Nardilysin

General Information

Protein names	- Nardilysin - 3.4.24.61 - N-arginine dibasic convertase - NRD convertase - NRD-C - Nardilysin convertase {ECO:0000312\|HGNC:HGNC:7995}
Gene names	NRD1
Organism	Homo sapiens
Protease Family	M16.005
Protease ID	M16.005
Chromosome location
UniProt ID	O43847

5 N-termini

3 C-termini

1 Cleavages

2 Substrates

Sequence

        10         20         30         40         50         60
MLRRVTVAAV CATRRKLCEA GRELAALWGI ETRGRCEDSA AARPFPILAM PGRNKAKSTC
        70         80         90        100        110        120
SCPDLQPNGQ DLGENSRVAR LGADESEEEG RRGSLSNAGD PEIVKSPSDP KQYRYIKLQN
       130        140        150        160        170        180
GLQALLISDL SNMEGKTGNT TDDEEEEEVE EEEEDDDEDS GAEIEDDDEE GFDDEDEFDD
       190        200        210        220        230        240
EHDDDLDTED NELEELEERA EARKKTTEKQ SAAALCVGVG SFADPDDLPG LAHFLEHMVF
       250        260        270        280        290        300
MGSLKYPDEN GFDAFLKKHG GSDNASTDCE RTVFQFDVQR KYFKEALDRW AQFFIHPLMI
       310        320        330        340        350        360
RDAIDREVEA VDSEYQLARP SDANRKEMLF GSLARPGHPM GKFFWGNAET LKHEPRKNNI
       370        380        390        400        410        420
DTHARLREFW MRYYSSHYMT LVVQSKETLD TLEKWVTEIF SQIPNNGLPR PNFGHLTDPF
       430        440        450        460        470        480
DTPAFNKLYR VVPIRKIHAL TITWALPPQQ QHYRVKPLHY ISWLVGHEGK GSILSFLRKK
       490        500        510        520        530        540
CWALALFGGN GETGFEQNST YSVFSISITL TDEGYEHFYE VAYTVFQYLK MLQKLGPEKR
       550        560        570        580        590        600
IFEEIRKIED NEFHYQEQTD PVEYVENMCE NMQLYPLQDI LTGDQLLFEY KPEVIGEALN
       610        620        630        640        650        660
QLVPQKANLV LLSGANEGKC DLKEKWFGTQ YSIEDIENSW AELWNSNFEL NPDLHLPAEN
       670        680        690        700        710        720
KYIATDFTLK AFDCPETEYP VKIVNTPQGC LWYKKDNKFK IPKAYIRFHL ISPLIQKSAA
       730        740        750        760        770        780
NVVLFDIFVN ILTHNLAEPA YEADVAQLEY KLVAGEHGLI IRVKGFNHKL PLLFQLIIDY
       790        800        810        820        830        840
LAEFNSTPAV FTMITEQLKK TYFNILIKPE TLAKDVRLLI LEYARWSMID KYQALMDGLS
       850        860        870        880        890        900
LESLLSFVKE FKSQLFVEGL VQGNVTSTES MDFLKYVVDK LNFKPLEQEM PVQFQVVELP
       910        920        930        940        950        960
SGHHLCKVKA LNKGDANSEV TVYYQSGTRS LREYTLMELL VMHMEEPCFD FLRTKQTLGY
       970        980        990       1000       1010       1020
HVYPTCRNTS GILGFSVTVG TQATKYNSEV VDKKIEEFLS SFEEKIENLT EEAFNTQVTA
      1030       1040       1050       1060       1070       1080
LIKLKECEDT HLGEEVDRNW NEVVTQQYLF DRLAHEIEAL KSFSKSDLVN WFKAHRGPGS
      1090       1100       1110       1120       1130       1140
KMLSVHVVGY GKYELEEDGT PSSEDSNSSC EVMQLTYLPT SPLLADCIIP ITDIRAFTTT
      1150
LNLLPYHKIV K

Isoforms

- Isoform 2 of Nardilysin - Isoform 2 of Nardilysin

Sequence View

        10         20         30         40         50         60
MLRRVTVAAV CATRRKLCEA GRELAALWGI ETRGRCEDSA AARPFPILAM PGRNKAKSTC
        70         80         90        100        110        120
SCPDLQPNGQ DLGENSRVAR LGADESEEEG RRGSLSNAGD PEIVKSPSDP KQYRYIKLQN
       130        140        150        160        170        180
GLQALLISDL SNMEGKTGNT TDDEEEEEVE EEEEDDDEDS GAEIEDDDEE GFDDEDEFDD
       190        200        210        220        230        240
EHDDDLDTED NELEELEERA EARKKTTEKQ SAAALCVGVG SFADPDDLPG LAHFLEHMVF
       250        260        270        280        290        300
MGSLKYPDEN GFDAFLKKHG GSDNASTDCE RTVFQFDVQR KYFKEALDRW AQFFIHPLMI
       310        320        330        340        350        360
RDAIDREVEA VDSEYQLARP SDANRKEMLF GSLARPGHPM GKFFWGNAET LKHEPRKNNI
       370        380        390        400        410        420
DTHARLREFW MRYYSSHYMT LVVQSKETLD TLEKWVTEIF SQIPNNGLPR PNFGHLTDPF
       430        440        450        460        470        480
DTPAFNKLYR VVPIRKIHAL TITWALPPQQ QHYRVKPLHY ISWLVGHEGK GSILSFLRKK
       490        500        510        520        530        540
CWALALFGGN GETGFEQNST YSVFSISITL TDEGYEHFYE VAYTVFQYLK MLQKLGPEKR
       550        560        570        580        590        600
IFEEIRKIED NEFHYQEQTD PVEYVENMCE NMQLYPLQDI LTGDQLLFEY KPEVIGEALN
       610        620        630        640        650        660
QLVPQKANLV LLSGANEGKC DLKEKWFGTQ YSIEDIENSW AELWNSNFEL NPDLHLPAEN
       670        680        690        700        710        720
KYIATDFTLK AFDCPETEYP VKIVNTPQGC LWYKKDNKFK IPKAYIRFHL ISPLIQKSAA
       730        740        750        760        770        780
NVVLFDIFVN ILTHNLAEPA YEADVAQLEY KLVAGEHGLI IRVKGFNHKL PLLFQLIIDY
       790        800        810        820        830        840
LAEFNSTPAV FTMITEQLKK TYFNILIKPE TLAKDVRLLI LEYARWSMID KYQALMDGLS
       850        860        870        880        890        900
LESLLSFVKE FKSQLFVEGL VQGNVTSTES MDFLKYVVDK LNFKPLEQEM PVQFQVVELP
       910        920        930        940        950        960
SGHHLCKVKA LNKGDANSEV TVYYQSGTRS LREYTLMELL VMHMEEPCFD FLRTKQTLGY
       970        980        990       1000       1010       1020
HVYPTCRNTS GILGFSVTVG TQATKYNSEV VDKKIEEFLS SFEEKIENLT EEAFNTQVTA
      1030       1040       1050       1060       1070       1080
LIKLKECEDT HLGEEVDRNW NEVVTQQYLF DRLAHEIEAL KSFSKSDLVN WFKAHRGPGS
      1090       1100       1110       1120       1130       1140
KMLSVHVVGY GKYELEEDGT PSSEDSNSSC EVMQLTYLPT SPLLADCIIP ITDIRAFTTT
      1150
LNLLPYHKIV K         10         20         30         40         50         60
MLRRVTVAAV CATRRKLCEA GRELAALWGI ETRGRCEDSA AARPFPILAM PGRNKAKSTC
        70         80         90        100        110        120
SCPDLQPNGQ DLGENSRVAR LGADESEEEG RRGSLSNAGD PEIVKSPSDP KQYRYIKLQN
       130        140        150        160        170        180
GLQALLISDL SNMEGKTGNT TDDEEEEEVE EEEEDDDEDS GAEIEDDDEE GFDDEDEFDD
       190        200        210        220        230        240
EHDDDLDTED NELEELEERA EARKKTTEKQ SAAALCVGVG SFADPDDLPG LAHFLEHMVF
       250        260        270        280        290        300
MGSLKYPDEN GFDAFLKKHG GSDNASTDCE RTVFQFDVQR KYFKEALDRW AQFFIHPLMI
       310        320        330        340        350        360
RDAIDREVEA VDSEYQLARP SDANRKEMLF GSLARPGHPM GKFFWGNAET LKHEPRKNNI
       370        380        390        400        410        420
DTHARLREFW MRYYSSHYMT LVVQSKETLD TLEKWVTEIF SQIPNNGLPR PNFGHLTDPF
       430        440        450        460        470        480
DTPAFNKLYR VVPIRKIHAL TITWALPPQQ QHYRVKPLHY ISWLVGHEGK GSILSFLRKK
       490        500        510        520        530        540
CWALALFGGN GETGFEQNST YSVFSISITL TDEGYEHFYE VAYTVFQYLK MLQKLGPEKR
       550        560        570        580        590        600
IFEEIRKIED NEFHYQEQTD PVEYVENMCE NMQLYPLQDI LTGDQLLFEY KPEVIGEALN
       610        620        630        640        650        660
QLVPQKANLV LLSGANEGKC DLKEKWFGTQ YSIEDIENSW AELWNSNFEL NPDLHLPAEN
       670        680        690        700        710        720
KYIATDFTLK AFDCPETEYP VKIVNTPQGC LWYKKDNKFK IPKAYIRFHL ISPLIQKSAA
       730        740        750        760        770        780
NVVLFDIFVN ILTHNLAEPA YEADVAQLEY KLVAGEHGLI IRVKGFNHKL PLLFQLIIDY
       790        800        810        820        830        840
LAEFNSTPAV FTMITEQLKK TYFNILIKPE TLAKDVRLLI LEYARWSMID KYQALMDGLS
       850        860        870        880        890        900
LESLLSFVKE FKSQLFVEGL VQGNVTSTES MDFLKYVVDK LNFKPLEQEM PVQFQVVELP
       910        920        930        940        950        960
SGHHLCKVKA LNKGDANSEV TVYYQSGTRS LREYTLMELL VMHMEEPCFD FLRTKQTLGY
       970        980        990       1000       1010       1020
HVYPTCRNTS GILGFSVTVG TQATKYNSEV VDKKIEEFLS SFEEKIENLT EEAFNTQVTA
      1030       1040       1050       1060       1070       1080
LIKLKECEDT HLGEEVDRNW NEVVTQQYLF DRLAHEIEAL KSFSKSDLVN WFKAHRGPGS
      1090       1100       1110       1120       1130       1140
KMLSVHVVGY GKYELEEDGT PSSEDSNSSC EVMQLTYLPT SPLLADCIIP ITDIRAFTTT
      1150
LNLLPYHKIV K

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
O43847-1-unknown	MLRRVT...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83256
O43847-21-unknown	GRELAA...	21	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
O43847-21-unknown	GRELAA...	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112631
O43847-51-unknown	PGRNKA...	51	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
O43847-51-unknown	PGRNKA...	51	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt196153
O43847-133-unknown	MEGKTG...	133	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000444416
O43847-133-unknown	MEGKTG...	133	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442262
O43847-133-unknown	MEGKTG...	133	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131685
O43847-649-unknown	ELNPDL...	649	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC5192
O43847-649-unknown	ELNPDL...	649	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt156004

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...WNSNFE	648	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC5192
...YHKIVK	1150		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...YHKIVK	1150	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...YHKIVK	1150	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt78874
...YHKIVK	1150		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
SMS_HUMAN	101	RERK.\|.KAGC	inferred from experiment	unknown	MEROPS		Merops NRDC_HUMAN -> SMS_HUMAN @101
ANF_HUMAN	126	SLRR.\|.RSSC	inferred from experiment	unknown	MEROPS		Merops NRDC_HUMAN -> ANF_HUMAN @126

TopFIND

O43847: Nardilysin

General Information

5

N-termini

3

C-termini

1

Cleavages

2

Substrates

Sequence

Isoforms

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Methodology:

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Protein Neighborhood

Domains & Features

5 N-termini - 3 C-termini - 1 Cleavages - 2 Substrates

N-termini

C-termini

Cleavages

Substrates