P01160: Natriuretic peptides A

General Information

Protein names	- Natriuretic peptides A - CDD-ANF - Cardiodilatin - CDD - Cardiodilatin-related peptide - CDP - Prepronatriodilatin - Atrial natriuretic factor - ANF - Atrial natriuretic peptide - ANP
Gene names	NPPA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P01160

10 N-termini

11 C-termini

16 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSSFSTTTVS FLLLLAFQLL GQTRANPMYN AVSNADLMDF KNLLDHLEEK MPLEDEVVPP
        70         80         90        100        110        120
QVLSEPNEEA GAALSPLPEV PPWTGEVSPA QRDGGALGRG PWDSSDRSAL LKSKLRALLT
       130        140        150
APRSLRRSSC FGGRMDRIGA QSGLGCNSFR YRR

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

10 N-termini - 11 C-termini - 16 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P01160-51-unknown	MPLEDE...	51	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000365659
P01160-124-unknown	SLRRSS...	124	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC223
P01160-124-unknown	SLRRSS...	124	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8438
P01160-127-unknown	RSSCFG...	127	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26773
P01160-127-unknown	RSSCFG...	127	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15600
P01160-128-unknown	SSCFGG...	128	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26677
P01160-131-unknown	FGGRMD...	131	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26678
P01160-131-unknown	FGGRMD...	131	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15601
P01160-135-unknown	MDRIGA...	135	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26679
P01160-137-unknown	RIGAQS...	137	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15602
P01160-137-unknown	RIGAQS...	137	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27635
P01160-138-unknown	IGAQSG...	138	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26680
P01160-140-unknown	AQSGLG...	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26681
P01160-144-unknown	LGCNSF...	144	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26682

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LTAPRS	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC223
...LTAPRS	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8438
...PRSLRR	126	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26773
...PRSLRR	126	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15600
...RSLRRS	127	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26677
...RRSSCF	130	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26678
...RRSSCF	130	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15601
...CFGGRM	134	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26679
...GGRMDR	136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15602
...GGRMDR	136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27635
...GRMDRI	137	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26680
...MDRIGA	139	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26681
...GAQSGL	143	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26682
...LGCNSF	148	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26683
...LGCNSF	148	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15603
...LGCNSF	148	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27636
...NSFRYR	151	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000365663
...NSFRYR	151	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000365659

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
AMPB_HUMAN	123	APRS.\|.SLRR	inferred from experiment	unknown	MEROPS		Merops AMPB_HUMAN -> ANF_HUMAN @123
CORIN_HUMAN	123	APRS.\|.SLRR	inferred from experiment	unknown	MEROPS	Wu Q	Wu F et al.:Processing of pro-atrial natriu... (S01.019)	11884416,
NRDC_HUMAN	126	SLRR.\|.RSSC	inferred from experiment	unknown	MEROPS		Merops NRDC_HUMAN -> ANF_HUMAN @126
IDE_HUMAN	126	SLRR.\|.RSSC	inferred from experiment	unknown	MEROPS	Kanaya S	Cornista J et al.:Cleavage of various peptides wi... (M16.002)	15502359,
NEP_HUMAN	127	LRRS.\|.SSCF	inferred from experiment	unknown	MEROPS	Deschodt-Lanckman M	Vanneste Y et al.:Hydrolysis of alpha-human atria... (M13.001)	2972276,
NEP_HUMAN	130	SSCF.\|.FGGR	inferred from experiment	unknown	MEROPS	Deschodt-Lanckman M	Vanneste Y et al.:Hydrolysis of alpha-human atria... (M13.001)	2972276,
IDE_HUMAN	130	SSCF.\|.FGGR	inferred from experiment	unknown	MEROPS	Kanaya S	Cornista J et al.:Cleavage of various peptides wi... (M16.002)	15502359,
NEP_HUMAN	134	GGRM.\|.MDRI	inferred from experiment	unknown	MEROPS	Deschodt-Lanckman M	Vanneste Y et al.:Hydrolysis of alpha-human atria... (M13.001)	2972276,
IDE_HUMAN	136	RMDR.\|.RIGA	inferred from experiment	unknown	MEROPS	Kanaya S	Cornista J et al.:Cleavage of various peptides wi... (M16.002)	15502359,
PREP_HUMAN	136	RMDR.\|.RIGA	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,
NEP_HUMAN	137	MDRI.\|.IGAQ	inferred from experiment	unknown	MEROPS	Deschodt-Lanckman M	Vanneste Y et al.:Hydrolysis of alpha-human atria... (M13.001)	2972276,
NEP_HUMAN	139	RIGA.\|.AQSG	inferred from experiment	unknown	MEROPS	Deschodt-Lanckman M	Vanneste Y et al.:Hydrolysis of alpha-human atria... (M13.001)	2972276,
NEP_HUMAN	143	QSGL.\|.LGCN	inferred from experiment	unknown	MEROPS	Deschodt-Lanckman M	Vanneste Y et al.:Hydrolysis of alpha-human atria... (M13.001)	2972276,
NEP_HUMAN	148	CNSF.\|.FRYR	inferred from experiment	unknown	MEROPS	Deschodt-Lanckman M	Vanneste Y et al.:Hydrolysis of alpha-human atria... (M13.001)	2972276,
IDE_HUMAN	148	CNSF.\|.FRYR	inferred from experiment	unknown	MEROPS	Kanaya S	Cornista J et al.:Cleavage of various peptides wi... (M16.002)	15502359,
PREP_HUMAN	148	CNSF.\|.FRYR	inferred from experiment	unknown	MEROPS	Hersh LB	Chow KM et al.:Mammalian pitrilysin: substrate... (M16.009)	19196155,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)