Q9Y5Q5: Atrial natriuretic peptide-converting enzyme

General Information

Protein names	- Atrial natriuretic peptide-converting enzyme - 3.4.21.- - Corin - Heart-specific serine proteinase ATC2 - Pro-ANP-converting enzyme - Transmembrane protease serine 10 - Atrial natriuretic peptide-converting enzyme, N-terminal propeptide - Atrial natriuretic peptide-converting enzyme, activated protease fragment - Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment - Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment - Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment
Gene names	CORIN
Organism	Homo sapiens
Protease Family	S01.019
Protease ID	S01.019
Chromosome location
UniProt ID	Q9Y5Q5

6 N-termini

4 C-termini

2 Cleavages

5 Substrates

Sequence

        10         20         30         40         50         60
MKQSPALAPE ERCRRAGSPK PVLRADDNNM GNGCSQKLAT ANLLRFLLLV LIPCICALVL
        70         80         90        100        110        120
LLVILLSYVG TLQKVYFKSN GSEPLVTDGE IQGSDVILTN TIYNQSTVVS TAHPDQHVPA
       130        140        150        160        170        180
WTTDASLPGD QSHRNTSACM NITHSQCQML PYHATLTPLL SVVRNMEMEK FLKFFTYLHR
       190        200        210        220        230        240
LSCYQHIMLF GCTLAFPECI IDGDDSHGLL PCRSFCEAAK EGCESVLGMV NYSWPDFLRC
       250        260        270        280        290        300
SQFRNQTESS NVSRICFSPQ QENGKQLLCG RGENFLCASG ICIPGKLQCN GYNDCDDWSD
       310        320        330        340        350        360
EAHCNCSENL FHCHTGKCLN YSLVCDGYDD CGDLSDEQNC DCNPTTEHRC GDGRCIAMEW
       370        380        390        400        410        420
VCDGDHDCVD KSDEVNCSCH SQGLVECRNG QCIPSTFQCD GDEDCKDGSD EENCSVIQTS
       430        440        450        460        470        480
CQEGDQRCLY NPCLDSCGGS SLCDPNNSLN NCSQCEPITL ELCMNLPYNS TSYPNYFGHR
       490        500        510        520        530        540
TQKEASISWE SSLFPALVQT NCYKYLMFFS CTILVPKCDV NTGEHIPPCR ALCEHSKERC
       550        560        570        580        590        600
ESVLGIVGLQ WPEDTDCSQF PEENSDNQTC LMPDEYVEEC SPSHFKCRSG QCVLASRRCD
       610        620        630        640        650        660
GQADCDDDSD EENCGCKERD LWECPSNKQC LKHTVICDGF PDCPDYMDEK NCSFCQDDEL
       670        680        690        700        710        720
ECANHACVSR DLWCDGEADC SDSSDEWDCV TLSINVNSSS FLMVHRAATE HHVCADGWQE
       730        740        750        760        770        780
ILSQLACKQM GLGEPSVTKL IQEQEKEPRW LTLHSNWESL NGTTLHELLV NGQSCESRSK
       790        800        810        820        830        840
ISLLCTKQDC GRRPAARMNK RILGGRTSRP GRWPWQCSLQ SEPSGHICGC VLIAKKWVLT
       850        860        870        880        890        900
VAHCFEGREN AAVWKVVLGI NNLDHPSVFM QTRFVKTIIL HPRYSRAVVD YDISIVELSE
       910        920        930        940        950        960
DISETGYVRP VCLPNPEQWL EPDTYCYITG WGHMGNKMPF KLQEGEVRII SLEHCQSYFD
       970        980        990       1000       1010       1020
MKTITTRMIC AGYESGTVDS CMGDSGGPLV CEKPGGRWTL FGLTSWGSVC FSKVLGPGVY
      1030       1040
SNVSYFVEWI KRQIYIQTFL LN

Isoforms

- Isoform 2 of Atrial natriuretic peptide-converting enzyme

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 2 Cleavages - 5 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9Y5Q5-0-unknown	NMKQSP...	0	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9Y5Q5-1-unknown	MKQSPA...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9Y5Q5-30-unknown	MGNGCS...	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt71445
Q9Y5Q5-165-unknown	NMEMEK...	165	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9Y5Q5-165-unknown	NMEMEK...	165	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8439
Q9Y5Q5-165-unknown	NMEMEK...	165	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115980
Q9Y5Q5-428-unknown	CLYNPC...	428	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9Y5Q5-428-unknown	CLYNPC...	428	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8441
Q9Y5Q5-428-unknown	CLYNPC...	428	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116209
Q9Y5Q5-802-unknown	ILGGRT...	802	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9Y5Q5-802-unknown	ILGGRT...	802	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116378

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LSVVRN	164	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8439
...LSVVRN	164	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127401
...EGDQRC	427	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8441
...EGDQRC	427	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135407
...RMNKRI	801	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RMNKRI	801	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt93387
...TFLLN	1042	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TFLLN	1042	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt67063

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CORIN_HUMAN	164	VVRN.\|.NMEM	inferred from experiment	unknown	MEROPS	Wu Q	Jiang J et al.:Ectodomain shedding and autocle... (S01.019)	21288900,
CORIN_HUMAN	427	DQRC.\|.CLYN	inferred from experiment	unknown	MEROPS	Wu Q	Jiang J et al.:Ectodomain shedding and autocle... (S01.019)	21288900,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ANF_HUMAN	123	APRS.\|.SLRR	inferred from experiment	unknown	MEROPS	Wu Q	Wu F et al.:Processing of pro-atrial natriu... (S01.019)	11884416,
CORIN-Isoform2_HUMAN	135	VVRN.\|.NMEM	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8439
CORIN_HUMAN	164	VVRN.\|.NMEM	inferred from experiment	unknown	MEROPS	Wu Q	Jiang J et al.:Ectodomain shedding and autocle... (S01.019)	21288900,
CORIN-Isoform2_HUMAN	398	DQRC.\|.CLYN	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC8441
CORIN_HUMAN	427	DQRC.\|.CLYN	inferred from experiment	unknown	MEROPS	Wu Q	Jiang J et al.:Ectodomain shedding and autocle... (S01.019)	21288900,