Q9H4A4: Aminopeptidase B

General Information

Protein names	- Aminopeptidase B - AP-B - 3.4.11.6 - Arginine aminopeptidase - Arginyl aminopeptidase
Gene names	RNPEP
Organism	Homo sapiens
Protease Family	M01.014
Protease ID	M01.014
Chromosome location
UniProt ID	Q9H4A4

3 N-termini

3 C-termini

0 Cleavages

7 Substrates

Sequence

        10         20         30         40         50         60
MASGEHSPGS GAARRPLHSA QAVDVASASN FRAFELLHLH LDLRAEFGPP GPGAGSRGLS
        70         80         90        100        110        120
GTAVLDLRCL EPEGAAELRL DSHPCLEVTA AALRRERPGS EEPPAEPVSF YTQPFSHYGQ
       130        140        150        160        170        180
ALCVSFPQPC RAAERLQVLL TYRVGEGPGV CWLAPEQTAG KKKPFVYTQG QAVLNRAFFP
       190        200        210        220        230        240
CFDTPAVKYK YSALIEVPDG FTAVMSASTW EKRGPNKFFF QMCQPIPSYL IALAIGDLVS
       250        260        270        280        290        300
AEVGPRSRVW AEPCLIDAAK EEYNGVIEEF LATGEKLFGP YVWGRYDLLF MPPSFPFGGM
       310        320        330        340        350        360
ENPCLTFVTP CLLAGDRSLA DVIIHEISHS WFGNLVTNAN WGEFWLNEGF TMYAQRRIST
       370        380        390        400        410        420
ILFGAAYTCL EAATGRALLR QHMDITGEEN PLNKLRVKIE PGVDPDDTYN ETPYEKGFCF
       430        440        450        460        470        480
VSYLAHLVGD QDQFDSFLKA YVHEFKFRSI LADDFLDFYL EYFPELKKKR VDIIPGFEFD
       490        500        510        520        530        540
RWLNTPGWPP YLPDLSPGDS LMKPAEELAQ LWAAEELDMK AIEAVAISPW KTYQLVYFLD
       550        560        570        580        590        600
KILQKSPLPP GNVKKLGDTY PSISNARNAE LRLRWGQIVL KNDHQEDFWK VKEFLHNQGK
       610        620        630        640        650
QKYTLPLYHA MMGGSEVAQT LAKETFASTA SQLHSNVVNY VQQIVAPKGS

Isoforms

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 0 Cleavages - 7 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H4A4-2-unknown	MASGEH...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H4A4-2-Acetylation	ASGEHS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H4A4-2-Acetylation	ASGEHS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9H4A4-255-unknown	LIDAAK...	255		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000407614

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...LDFYLE	460	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000407614
...VDIIPG	475	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000389602
...APKGS	650	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
LAP2A_HUMAN	33	EQRK.\|.KDVY	inferred from experiment	unknown	MEROPS		Merops AMPB_HUMAN -> LAP2A_HUMAN @33
INS_HUMAN	89	QKRG.\|.GIVE	inferred from experiment	unknown	MEROPS		Merops AMPB_HUMAN -> INS_HUMAN @89
INS_HUMAN	89	QKRG.\|.GIVE	inferred from experiment	unknown	MEROPS	Authier F	Kouach M et al.:Endosomal proteolysis of intern... (M01.014)	19834685,
TKN1_HUMAN	98	KRHK.\|.KTDS	inferred from experiment	unknown	MEROPS		Merops AMPB_HUMAN -> TKN1_HUMAN @98
SMS_HUMAN	101	RERK.\|.KAGC	inferred from experiment	unknown	MEROPS		Merops AMPB_HUMAN -> SMS_HUMAN @101
ANF_HUMAN	123	APRS.\|.SLRR	inferred from experiment	unknown	MEROPS		Merops AMPB_HUMAN -> ANF_HUMAN @123
PDYN_HUMAN	174	VKRY.\|.YGGF	inferred from experiment	unknown	MEROPS		Merops AMPB_HUMAN -> PDYN_HUMAN @174
COLI_HUMAN	236	DKRY.\|.YGGF	inferred from experiment	unknown	MEROPS		Merops AMPB_HUMAN -> COLI_HUMAN @236