P42166: Lamina-associated polypeptide 2, isoform alpha

General Information

Protein names	- Lamina-associated polypeptide 2, isoform alpha - Thymopoietin isoform alpha - TP alpha - Thymopoietin-related peptide isoform alpha - TPRP isoform alpha - Thymopoietin - TP - Splenin - Thymopentin - TP5
Gene names	TMPO
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P42166

11 N-termini

8 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MPEFLEDPSV LTKDKLKSEL VANNVTLPAG EQRKDVYVQL YLQHLTARNR PPLPAGTNSK
        70         80         90        100        110        120
GPPDFSSDEE REPTPVLGSG AAAAGRSRAA VGRKATKKTD KPRQEDKDDL DVTELTNEDL
       130        140        150        160        170        180
LDQLVKYGVN PGPIVGTTRK LYEKKLLKLR EQGTESRSST PLPTISSSAE NTRQNGSNDS
       190        200        210        220        230        240
DRYSDNEEGK KKEHKKVKST RDIVPFSELG TTPSGGGFFQ GISFPEISTR PPLGSTELQA
       250        260        270        280        290        300
AKKVHTSKGD LPREPLVATN LPGRGQLQKL ASERNLFISC KSSHDRCLEK SSSSSSQPEH
       310        320        330        340        350        360
SAMLVSTAAS PSLIKETTTG YYKDIVENIC GREKSGIQPL CPERSHISDQ SPLSSKRKAL
       370        380        390        400        410        420
EESESSQLIS PPLAQAIRDY VNSLLVQGGV GSLPGTSNSM PPLDVENIQK RIDQSKFQET
       430        440        450        460        470        480
EFLSPPRKVP RLSEKSVEER DSGSFVAFQN IPGSELMSSF AKTVVSHSLT TLGLEVAKQS
       490        500        510        520        530        540
QHDKIDASEL SFPFHESILK VIEEEWQQVD RQLPSLACKY PVSSREATQI LSVPKVDDEI
       550        560        570        580        590        600
LGFISEATPL GGIQAASTES CNQQLDLALC RAYEAAASAL QIATHTAFVA KAMQADISQA
       610        620        630        640        650        660
AQILSSDPSR THQALGILSK TYDAASYICE AAFDEVKMAA HTMGNATVGR RYLWLKDCKI
       670        680        690
NLASKNKLAS TPFKGGTLFG GEVCKVIKKR GNKH

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

11 N-termini - 8 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P42166-2-unknown	PEFLED...	2	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P42166-2-unknown	PEFLED...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
P42166-34-unknown	KDVYVQ...	34	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC228
P42166-36-unknown	VYVQLY...	36	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26765
P42166-59-	SKGPPD...	59		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P42166-59-	SKGPPD...	59		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P42166-94-unknown	KATKKT...	94	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10071
P42166-158-unknown	SSTPLP...	158	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC10072
P42166-257-unknown	VATNLP...	257	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14123
P42166-414-unknown	QSKFQE...	414	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1822
P42166-442-	SGSFVA...	442		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P42166-442-	SGSFVA...	442		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P42166-442-unknown	SGSFVA...	442	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1823
P42166-442-unknown	SGSFVA...	442	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2554
P42166-487-	ASELSF...	487		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P42166-487-	ASELSF...	487		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AGEQRK	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC228
...EQRKDV	35	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26765
...AAVGRK	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10071
...GTESRS	157	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC10072
...PREPLV	256	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14123
...QKRIDQ	413	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1822
...VEERDS	441	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1823
...VEERDS	441	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2554
...RGNKH	694	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
AMPB_HUMAN	33	EQRK.\|.KDVY	inferred from experiment	unknown	MEROPS		Merops AMPB_HUMAN -> LAP2A_HUMAN @33
NEP_HUMAN	35	RKDV.\|.VYVQ	inferred from experiment	unknown	MEROPS	Auberger P	Guerin S et al.:CD10 is expressed on human thym... (M13.001)	9337153,
GRAA_HUMAN	93	VGRK.\|.KATK	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAA_HUMAN	157	ESRS.\|.SSTP	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:The substrate specificity profi... (S01.135)	20536382,
GRAM_HUMAN	256	EPLV.\|.VATN	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CASP3_HUMAN	413	RIDQ.\|.QSKF	inferred from experiment	unknown	MEROPS	Courvalin JC	Buendia B et al.:Caspase-dependent proteolysis o... (C14.003)	10318766,
CASP3_HUMAN	441	ERDS.\|.SGSF	inferred from experiment	unknown	MEROPS	Foisner R	Gotzmann J et al.:Caspase-mediated cleavage of th... (C14.003)	11034905,
CASP6_HUMAN	441	ERDS.\|.SGSF	inferred from experiment	unknown	MEROPS	Foisner R	Gotzmann J et al.:Caspase-mediated cleavage of th... (C14.003)	11034905,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)