P05106: Integrin beta-3 {ECO:0000305}
Protein names | - Integrin beta-3 {ECO:0000305} - Platelet membrane glycoprotein IIIa {ECO:0000305} - GPIIIa {ECO:0000305} - CD61 |
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Gene names | ITGB3 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | P05106 |
6
N-termini
6
C-termini
5
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MRARPRPRPL WATVLALGAL AGVGVGGPNI CTTRGVSSCQ QCLAVSPMCA WCSDEALPLG
70 80 90 100 110 120
SPRCDLKENL LKDNCAPESI EFPVSEARVL EDRPLSDKGS GDSSQVTQVS PQRIALRLRP
130 140 150 160 170 180
DDSKNFSIQV RQVEDYPVDI YYLMDLSYSM KDDLWSIQNL GTKLATQMRK LTSNLRIGFG
190 200 210 220 230 240
AFVDKPVSPY MYISPPEALE NPCYDMKTTC LPMFGYKHVL TLTDQVTRFN EEVKKQSVSR
250 260 270 280 290 300
NRDAPEGGFD AIMQATVCDE KIGWRNDASH LLVFTTDAKT HIALDGRLAG IVQPNDGQCH
310 320 330 340 350 360
VGSDNHYSAS TTMDYPSLGL MTEKLSQKNI NLIFAVTENV VNLYQNYSEL IPGTTVGVLS
370 380 390 400 410 420
MDSSNVLQLI VDAYGKIRSK VELEVRDLPE ELSLSFNATC LNNEVIPGLK SCMGLKIGDT
430 440 450 460 470 480
VSFSIEAKVR GCPQEKEKSF TIKPVGFKDS LIVQVTFDCD CACQAQAEPN SHRCNNGNGT
490 500 510 520 530 540
FECGVCRCGP GWLGSQCECS EEDYRPSQQD ECSPREGQPV CSQRGECLCG QCVCHSSDFG
550 560 570 580 590 600
KITGKYCECD DFSCVRYKGE MCSGHGQCSC GDCLCDSDWT GYYCNCTTRT DTCMSSNGLL
610 620 630 640 650 660
CSGRGKCECG SCVCIQPGSY GDTCEKCPTC PDACTFKKEC VECKKFDRGA LHDENTCNRY
670 680 690 700 710 720
CRDEIESVKE LKDTGKDAVN CTYKNEDDCV VRFQYYEDSS GKSILYVVEE PECPKGPDIL
730 740 750 760 770 780
VVLLSVMGAI LLIGLAALLI WKLLITIHDR KEFAKFEEER ARAKWDTANN PLYKEATSTF
TNITYRGT
Isoforms
- Isoform Beta-3B of Integrin beta-3 - Isoform Beta-3C of Integrin beta-3Sequence View
10 20 30 40 50 60
MRARPRPRPL WATVLALGAL AGVGVGGPNI CTTRGVSSCQ QCLAVSPMCA WCSDEALPLG
70 80 90 100 110 120
SPRCDLKENL LKDNCAPESI EFPVSEARVL EDRPLSDKGS GDSSQVTQVS PQRIALRLRP
130 140 150 160 170 180
DDSKNFSIQV RQVEDYPVDI YYLMDLSYSM KDDLWSIQNL GTKLATQMRK LTSNLRIGFG
190 200 210 220 230 240
AFVDKPVSPY MYISPPEALE NPCYDMKTTC LPMFGYKHVL TLTDQVTRFN EEVKKQSVSR
250 260 270 280 290 300
NRDAPEGGFD AIMQATVCDE KIGWRNDASH LLVFTTDAKT HIALDGRLAG IVQPNDGQCH
310 320 330 340 350 360
VGSDNHYSAS TTMDYPSLGL MTEKLSQKNI NLIFAVTENV VNLYQNYSEL IPGTTVGVLS
370 380 390 400 410 420
MDSSNVLQLI VDAYGKIRSK VELEVRDLPE ELSLSFNATC LNNEVIPGLK SCMGLKIGDT
430 440 450 460 470 480
VSFSIEAKVR GCPQEKEKSF TIKPVGFKDS LIVQVTFDCD CACQAQAEPN SHRCNNGNGT
490 500 510 520 530 540
FECGVCRCGP GWLGSQCECS EEDYRPSQQD ECSPREGQPV CSQRGECLCG QCVCHSSDFG
550 560 570 580 590 600
KITGKYCECD DFSCVRYKGE MCSGHGQCSC GDCLCDSDWT GYYCNCTTRT DTCMSSNGLL
610 620 630 640 650 660
CSGRGKCECG SCVCIQPGSY GDTCEKCPTC PDACTFKKEC VECKKFDRGA LHDENTCNRY
670 680 690 700 710 720
CRDEIESVKE LKDTGKDAVN CTYKNEDDCV VRFQYYEDSS GKSILYVVEE PECPKGPDIL
730 740 750 760 770 780
VVLLSVMGAI LLIGLAALLI WKLLITIHDR KEFAKFEEER ARAKWDTANN PLYKEATSTF
TNITYRGT
10 20 30 40 50 60
MRARPRPRPL WATVLALGAL AGVGVGGPNI CTTRGVSSCQ QCLAVSPMCA WCSDEALPLG
70 80 90 100 110 120
SPRCDLKENL LKDNCAPESI EFPVSEARVL EDRPLSDKGS GDSSQVTQVS PQRIALRLRP
130 140 150 160 170 180
DDSKNFSIQV RQVEDYPVDI YYLMDLSYSM KDDLWSIQNL GTKLATQMRK LTSNLRIGFG
190 200 210 220 230 240
AFVDKPVSPY MYISPPEALE NPCYDMKTTC LPMFGYKHVL TLTDQVTRFN EEVKKQSVSR
250 260 270 280 290 300
NRDAPEGGFD AIMQATVCDE KIGWRNDASH LLVFTTDAKT HIALDGRLAG IVQPNDGQCH
310 320 330 340 350 360
VGSDNHYSAS TTMDYPSLGL MTEKLSQKNI NLIFAVTENV VNLYQNYSEL IPGTTVGVLS
370 380 390 400 410 420
MDSSNVLQLI VDAYGKIRSK VELEVRDLPE ELSLSFNATC LNNEVIPGLK SCMGLKIGDT
430 440 450 460 470 480
VSFSIEAKVR GCPQEKEKSF TIKPVGFKDS LIVQVTFDCD CACQAQAEPN SHRCNNGNGT
490 500 510 520 530 540
FECGVCRCGP GWLGSQCECS EEDYRPSQQD ECSPREGQPV CSQRGECLCG QCVCHSSDFG
550 560 570 580 590 600
KITGKYCECD DFSCVRYKGE MCSGHGQCSC GDCLCDSDWT GYYCNCTTRT DTCMSSNGLL
610 620 630 640 650 660
CSGRGKCECG SCVCIQPGSY GDTCEKCPTC PDACTFKKEC VECKKFDRGA LHDENTCNRY
670 680 690 700 710 720
CRDEIESVKE LKDTGKDAVN CTYKNEDDCV VRFQYYEDSS GKSILYVVEE PECPKGPDIL
730 740 750 760 770 780
VVLLSVMGAI LLIGLAALLI WKLLITIHDR KEFAKFEEER ARAKWDTANN PLYKEATSTF
TNITYRGT
Protein Neighborhood
Domains & Features
6 N-termini - 6 C-termini - 5 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
P05106-1-unknown | MRARPR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt78161 | |||
P05106-1-unknown | MRARPR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt78162 | |||
P05106-27-unknown | GPNICT... | 27 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
P05106-27-unknown | GPNICT... | 27 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt114240 | |||
P05106-27-unknown | GPNICT... | 27 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt114241 | |||
P05106-762-unknown | RAKWDT... | 762 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC722 | |||
P05106-768-unknown | ANNPLY... | 768 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC723 | |||
P05106-774-unknown | KEATST... | 774 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC724 | |||
P05106-781-unknown | TNITYR... | 781 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC725 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...EEERAR | 761 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC722 | |||
...AKWDTA | 767 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC723 | |||
...NNPLYK | 773 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC724 | |||
...ATSTFT | 780 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC725 | |||
...TNITYR | 785 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC726 | |||
...TYRGT | 788 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CAN1_HUMAN | 761 | ERAR.|.RAKW | inferred from experiment | unknown | MEROPS | Ginsberg MH | Du X et al.:Calpain cleavage of the cytopla... (C02.001) | 7592818, |
CAN1_HUMAN | 767 | WDTA.|.ANNP | inferred from experiment | unknown | MEROPS | Ginsberg MH | Du X et al.:Calpain cleavage of the cytopla... (C02.001) | 7592818, |
CAN1_HUMAN | 773 | PLYK.|.KEAT | inferred from experiment | unknown | MEROPS | Ginsberg MH | Du X et al.:Calpain cleavage of the cytopla... (C02.001) | 7592818, |
CAN1_HUMAN | 780 | STFT.|.TNIT | inferred from experiment | unknown | MEROPS | Ginsberg MH | Du X et al.:Calpain cleavage of the cytopla... (C02.001) | 7592818, |
CAN1_HUMAN | 785 | ITYR.|.RGT | inferred from experiment | unknown | MEROPS | Ginsberg MH | Du X et al.:Calpain cleavage of the cytopla... (C02.001) | 7592818, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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