Q16637: Survival motor neuron protein

General Information

Protein names	- Survival motor neuron protein - Component of gems 1 - Gemin-1
Gene names	SMN2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q16637

11 N-termini

5 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform SMN-delta5 of Survival motor neuron protein - Isoform SMN-delta7 of Survival motor neuron protein - Isoform SMN-delta57 of Survival motor neuron protein

Sequence View

        10         20         30         40         50         60
MAMSSGGSGG GVPEQEDSVL FRRGTGQSDD SDIWDDTALI KAYDKAVASF KHALKNGDIC
        70         80         90        100        110        120
ETSGKPKTTP KRKPAKKNKS QKKNTAASLQ QWKVGDKCSA IWSEDGCIYP ATIASIDFKR
       130        140        150        160        170        180
ETCVVVYTGY GNREEQNLSD LLSPICEVAN NIEQNAQENE NESQVSTDES ENSRSPGNKS
       190        200        210        220        230        240
DNIKPKSAPW NSFLPPPPPM PGPRLGPGKP GLKFNGPPPP PPPPPPHLLS CWLPPFPSGP
       250        260        270        280        290
PIIPPPPPIC PDSLDDADAL GSMLISWYMS GYHTGYYMGF RQNQKEGRCS HSLN         10         20         30         40         50         60
MAMSSGGSGG GVPEQEDSVL FRRGTGQSDD SDIWDDTALI KAYDKAVASF KHALKNGDIC
        70         80         90        100        110        120
ETSGKPKTTP KRKPAKKNKS QKKNTAASLQ QWKVGDKCSA IWSEDGCIYP ATIASIDFKR
       130        140        150        160        170        180
ETCVVVYTGY GNREEQNLSD LLSPICEVAN NIEQNAQENE NESQVSTDES ENSRSPGNKS
       190        200        210        220        230        240
DNIKPKSAPW NSFLPPPPPM PGPRLGPGKP GLKFNGPPPP PPPPPPHLLS CWLPPFPSGP
       250        260        270        280        290
PIIPPPPPIC PDSLDDADAL GSMLISWYMS GYHTGYYMGF RQNQKEGRCS HSLN         10         20         30         40         50         60
MAMSSGGSGG GVPEQEDSVL FRRGTGQSDD SDIWDDTALI KAYDKAVASF KHALKNGDIC
        70         80         90        100        110        120
ETSGKPKTTP KRKPAKKNKS QKKNTAASLQ QWKVGDKCSA IWSEDGCIYP ATIASIDFKR
       130        140        150        160        170        180
ETCVVVYTGY GNREEQNLSD LLSPICEVAN NIEQNAQENE NESQVSTDES ENSRSPGNKS
       190        200        210        220        230        240
DNIKPKSAPW NSFLPPPPPM PGPRLGPGKP GLKFNGPPPP PPPPPPHLLS CWLPPFPSGP
       250        260        270        280        290
PIIPPPPPIC PDSLDDADAL GSMLISWYMS GYHTGYYMGF RQNQKEGRCS HSLN

Filter Information:

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

11 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q16637-2-unknown	MAMSSG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16637-1-unknown	MAMSSG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90052
Q16637-1-unknown	MAMSSG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90053
Q16637-1-unknown	MAMSSG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90054
Q16637-2-Acetylation	AMSSGG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q16637-2-Acetylation	AMSSGG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q16637-2-Acetylation	AMSSGG...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q16637-2-Acetylation	AMSSGG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q16637-2-Acetylation	AMSSGG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110193
Q16637-2-Acetylation	AMSSGG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110194
Q16637-2-Acetylation	AMSSGG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110195
Q16637-4-acetylation	SSGGSG...	4	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q16637-4-acetylation	SSGGSG...	4	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163331
Q16637-4-acetylation	SSGGSG...	4	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163332
Q16637-4-acetylation	SSGGSG...	4	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt163333
Q16637-55-unknown	KNGDIC...	55		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14535
Q16637-55-unknown	KNGDIC...	55		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139551
Q16637-55-unknown	KNGDIC...	55		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139552
Q16637-55-unknown	KNGDIC...	55		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139554
Q16637-156-unknown	AQENEN...	156		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC12398
Q16637-156-unknown	AQENEN...	156		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144984
Q16637-156-unknown	AQENEN...	156		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144985
Q16637-156-unknown	AQENEN...	156		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144986
Q16637-192-unknown	SFLPPP...	192		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167593
Q16637-192-	SFLPPP...	192			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q16637-192-	SFLPPP...	192			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q16637-192-	SFLPPP...	192			Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
Q16637-193-	FLPPPP...	193			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q16637-193-	FLPPPP...	193			Subtiligase Based Positive Selection		Wells	apoptotic_MM1SDBJurkat_Mix	23264352
Q16637-193-	FLPPPP...	193			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q16637-193-unknown	FLPPPP...	193		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC835
Q16637-193-unknown	FLPPPP...	193		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146351
Q16637-194-unknown	LPPPPP...	194		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC839
Q16637-194-unknown	LPPPPP...	194		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt146382

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...FKHALK	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14535
...FKHALK	54	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122643
...FKHALK	54	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122644
...FKHALK	54	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122646
...NIEQNA	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC12398
...NIEQNA	155	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128264
...NIEQNA	155	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128265
...NIEQNA	155	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128266
...APWNSF	192	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC835
...APWNSF	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129653
...APWNSF	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129655
...APWNSF	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129657
...PWNSFL	193	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC839
...PWNSFL	193	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129686
...PWNSFL	193	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129687
...PWNSFL	193	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129689
...SHSLN	294	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SHSLN	294	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85670

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	54	HALK.\|.KNGD	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
GRAB_HUMAN	155	EQNA.\|.AQEN	inferred from experiment	unknown	MEROPS	Gevaert K	Van Damme P et al.:Complementary positional proteo... (M14.017)	20526345,
CAN1_HUMAN	192	WNSF.\|.FLPP	inferred from experiment	unknown	MEROPS	Matera AG	Fuentes JL et al.:Molecular determinants of survi... (C02.001)	21209906,
CAN1_HUMAN	193	NSFL.\|.LPPP	inferred from experiment	unknown	MEROPS	Matera AG	Fuentes JL et al.:Molecular determinants of survi... (C02.001)	21209906,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)