Q5D862: Filaggrin-2
| Protein names | - Filaggrin-2 - FLG-2 - Intermediate filament-associated and psoriasis-susceptibility protein - Ifapsoriasin |
|---|---|
| Gene names | FLG2 |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q5D862 |
5
N-termini
5
C-termini
4
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MTDLLRSVVT VIDVFYKYTK QDGECGTLSK GELKELLEKE LHPVLKNPDD PDTVDVIMHM
70 80 90 100 110 120
LDRDHDRRLD FTEFLLMIFK LTMACNKVLS KEYCKASGSK KHRRGHRHQE EESETEEDEE
130 140 150 160 170 180
DTPGHKSGYR HSSWSEGEEH GYSSGHSRGT VKCRHGSNSR RLGRQGNLSS SGNQEGSQKR
190 200 210 220 230 240
YHRSSCGHSW SGGKDRHGSS SVELRERINK SHISPSRESG EEYESGSGSN SWERKGHGGL
250 260 270 280 290 300
SCGLETSGHE SNSTQSRIRE QKLGSSCSGS GDSGRRSHAC GYSNSSGCGR PQNASSSCQS
310 320 330 340 350 360
HRFGGQGNQF SYIQSGCQSG IKGGQGHGCV SGGQPSGCGQ PESNPCSQSY SQRGYGAREN
370 380 390 400 410 420
GQPQNCGGQW RTGSSQSSCC GQYGSGGSQS CSNGQHEYGS CGRFSNSSSS NEFSKCDQYG
430 440 450 460 470 480
SGSSQSTSFE QHGTGLSQSS GFEQHVCGSG QTCGQHESTS SQSLGYDQHG SSSGKTSGFG
490 500 510 520 530 540
QHGSGSGQSS GFGQCGSGSG QSSGFGQHGS VSGQSSGFGQ HGSVSGQSSG FGQHESRSRQ
550 560 570 580 590 600
SSYGQHGSGS SQSSGYGQYG SRETSGFGQH GLGSGQSTGF GQYGSGSGQS SGFGQHGSGS
610 620 630 640 650 660
GQSSGFGQHE SRSGQSSYGQ HSSGSSQSSG YGQHGSRQTS GFGQHGSGSS QSTGFGQYGS
670 680 690 700 710 720
GSGQSSGFGQ HVSGSGQSSG FGQHESRSGH SSYGQHGFGS SQSSGYGQHG SSSGQTSGFG
730 740 750 760 770 780
QHELSSGQSS SFGQHGSGSG QSSGFGQHGS GSGQSSGFGQ HESRSGQSSY GQHSSGSSQS
790 800 810 820 830 840
SGYGQHGSRQ TSGFGQHGSG SSQSTGFGQY GSGSGQSAGF GQHGSGSGQS SGFGQHESRS
850 860 870 880 890 900
HQSSYGQHGS GSSQSSGYGQ HGSSSGQTSG FGQHRSSSGQ YSGFGQHGSG SGQSSGFGQH
910 920 930 940 950 960
GTGSGQYSGF GQHESRSHQS SYGQHGSGSS QSSGYGQHGS SSGQTFGFGQ HRSGSGQSSG
970 980 990 1000 1010 1020
FGQHGSGSGQ SSGFGQHESG SGKSSGFGQH ESRSSQSNYG QHGSGSSQSS GYGQHGSSSG
1030 1040 1050 1060 1070 1080
QTTGFGQHRS SSGQYSGFGQ HGSGSDQSSG FGQHGTGSGQ SSGFGQYESR SRQSSYGQHG
1090 1100 1110 1120 1130 1140
SGSSQSSGYG QHGSNSGQTS GFGQHRPGSG QSSGFGQYGS GSGQSSGFGQ HGSGTGKSSG
1150 1160 1170 1180 1190 1200
FAQHEYRSGQ SSYGQHGTGS SQSSGCGQHE SGSGPTTSFG QHVSGSDNFS SSGQHISDSG
1210 1220 1230 1240 1250 1260
QSTGFGQYGS GSGQSTGLGQ GESQQVESGS TVHGRQETTH GQTINTTRHS QSGQGQSTQT
1270 1280 1290 1300 1310 1320
GSRVTRRRRS SQSENSDSEV HSKVSHRHSE HIHTQAGSHY PKSGSTVRRR QGTTHGQRGD
1330 1340 1350 1360 1370 1380
TTRHGHSGHG QSTQTGSRTS GRQRFSHSDA TDSEVHSGVS HRPHSQEQTH SQAGSQHGES
1390 1400 1410 1420 1430 1440
ESTVHERHET TYGQTGEATG HGHSGHGQST QRGSRTTGRR GSGHSESSDS EVHSGGSHRP
1450 1460 1470 1480 1490 1500
QSQEQTHGQA GSQHGESGST VHGRHGTTHG QTGDTTRHAH YHHGKSTQRG SSTTGRRGSG
1510 1520 1530 1540 1550 1560
HSESSDSEVH SGGSHTHSGH THGQSGSQHG ESESIIHDRH RITHGQTGDT TRHSYSGHEQ
1570 1580 1590 1600 1610 1620
TTQTGSRTTG RQRTSHSEST DSEVHSGGSH RPHSREHTYG QAGSQHEEPE FTVHERHGTT
1630 1640 1650 1660 1670 1680
HGQIGDTTGH SHSGHGQSTQ RGSRTTGRQR SSHSESSDSE VHSGVSHTHT GHTHGQAGSQ
1690 1700 1710 1720 1730 1740
HGQSESIVPE RHGTTHGQTG DTTRHAHYHH GLTTQTGSRT TGRRGSGHSE YSDSEGYSGV
1750 1760 1770 1780 1790 1800
SHTHSGHTHG QARSQHGESE SIVHERHGTI HGQTGDTTRH AHSGHGQSTQ TGSRTTGRRS
1810 1820 1830 1840 1850 1860
SGHSEYSDSE GHSGFSQRPH SRGHTHGQAG SQHGESESIV DERHGTTHGQ TGDTSGHSQS
1870 1880 1890 1900 1910 1920
GHGQSTQSGS STTGRRRSGH SESSDSEVHS GGSHTHSGHT HSQARSQHGE SESTVHKRHQ
1930 1940 1950 1960 1970 1980
TTHGQTGDTT EHGHPSHGQT IQTGSRTTGR RGSGHSEYSD SEGPSGVSHT HSGHTHGQAG
1990 2000 2010 2020 2030 2040
SHYPESGSSV HERHGTTHGQ TADTTRHGHS GHGQSTQRGS RTTGRRASGH SEYSDSEGHS
2050 2060 2070 2080 2090 2100
GVSHTHSGHA HGQAGSQHGE SGSSVHERHG TTHGQTGDTT RHAHSGHGQS TQRGSRTAGR
2110 2120 2130 2140 2150 2160
RGSGHSESSD SEVHSGVSHT HSGHTYGQAR SQHGESGSAI HGRQGTIHGQ TGDTTRHGQS
2170 2180 2190 2200 2210 2220
GHGQSTQTGS RTTGRQRSSH SESSDSEVHS EASPTHSGHT HSQAGSRHGQ SGSSGHGRQG
2230 2240 2250 2260 2270 2280
TTHGQTGDTT RHAHYGYGQS TQRGSRTTGR RGSGHSESSD SEVHSWGSHT HSGHIQGQAG
2290 2300 2310 2320 2330 2340
SQQRQPGSTV HGRLETTHGQ TGDTTRHGHS GYGQSTQTGS RSSRASHFQS HSSERQRHGS
2350 2360 2370 2380 2390
SQVWKHGSYG PAEYDYGHTG YGPSGGSRKS ISNSHLSWST DSTANKQLSR H
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
5 N-termini - 5 C-termini - 4 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q5D862-1-unknown | MTDLLR... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q5D862-1714-unknown | TQTGSR... | 1714 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC849 | |||
| Q5D862-1742-unknown | HTHSGH... | 1742 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC850 | |||
| Q5D862-1789-unknown | TQTGSR... | 1789 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC851 | |||
| Q5D862-1849-unknown | GQTGDT... | 1849 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC852 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...HHGLTT | 1713 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC849 | |||
| ...YSGVSH | 1741 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC850 | |||
| ...GHGQST | 1788 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC851 | |||
| ...HGTTHG | 1848 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC852 | |||
| ...QLSRH | 2391 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| CAN1_HUMAN | 1713 | GLTT.|.TQTG | inferred from experiment | unknown | MEROPS | Simon M | Hsu CY et al.:Deimination of human filaggrin-... (C02.001) | 21531719, |
| CAN1_HUMAN | 1741 | GVSH.|.HTHS | inferred from experiment | unknown | MEROPS | Simon M | Hsu CY et al.:Deimination of human filaggrin-... (C02.001) | 21531719, |
| CAN1_HUMAN | 1788 | GQST.|.TQTG | inferred from experiment | unknown | MEROPS | Simon M | Hsu CY et al.:Deimination of human filaggrin-... (C02.001) | 21531719, |
| CAN1_HUMAN | 1848 | TTHG.|.GQTG | inferred from experiment | unknown | MEROPS | Simon M | Hsu CY et al.:Deimination of human filaggrin-... (C02.001) | 21531719, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|