Q01082: Spectrin beta chain, non-erythrocytic 1

General Information

Protein names	- Spectrin beta chain, non-erythrocytic 1 - Beta-II spectrin - Fodrin beta chain - Spectrin, non-erythroid beta chain 1
Gene names	SPTBN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q01082

19 N-termini

8 C-termini

6 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Short of Spectrin beta chain, non-erythrocytic 1 - Isoform 2 of Spectrin beta chain, non-erythrocytic 1

Sequence View

        10         20         30         40         50         60
MTTTVATDYD NIEIQQQYSD VNNRWDVDDW DNENSSARLF ERSRIKALAD EREAVQKKTF
        70         80         90        100        110        120
TKWVNSHLAR VSCRITDLYT DLRDGRMLIK LLEVLSGERL PKPTKGRMRI HCLENVDKAL
       130        140        150        160        170        180
QFLKEQRVHL ENMGSHDIVD GNHRLTLGLI WTIILRFQIQ DISVETEDNK EKKSAKDALL
       190        200        210        220        230        240
LWCQMKTAGY PNVNIHNFTT SWRDGMAFNA LIHKHRPDLI DFDKLKKSNA HYNLQNAFNL
       250        260        270        280        290        300
AEQHLGLTKL LDPEDISVDH PDEKSIITYV VTYYHYFSKM KALAVEGKRI GKVLDNAIET
       310        320        330        340        350        360
EKMIEKYESL ASDLLEWIEQ TIIILNNRKF ANSLVGVQQQ LQAFNTYRTV EKPPKFTEKG
       370        380        390        400        410        420
NLEVLLFTIQ SKMRANNQKV YMPREGKLIS DINKAWERLE KAEHERELAL RNELIRQEKL
       430        440        450        460        470        480
EQLARRFDRK AAMRETWLSE NQRLVSQDNF GFDLPAVEAA TKKHEAIETD IAAYEERVQA
       490        500        510        520        530        540
VVAVARELEA ENYHDIKRIT ARKDNVIRLW EYLLELLRAR RQRLEMNLGL QKIFQEMLYI
       550        560        570        580        590        600
MDWMDEMKVL VLSQDYGKHL LGVEDLLQKH TLVEADIGIQ AERVRGVNAS AQKFATDGEG
       610        620        630        640        650        660
YKPCDPQVIR DRVAHMEFCY QELCQLAAER RARLEESRRL WKFFWEMAEE EGWIREKEKI
       670        680        690        700        710        720
LSSDDYGKDL TSVMRLLSKH RAFEDEMSGR SGHFEQAIKE GEDMIAEEHF GSEKIRERII
       730        740        750        760        770        780
YIREQWANLE QLSAIRKKRL EEASLLHQFQ ADADDIDAWM LDILKIVSSS DVGHDEYSTQ
       790        800        810        820        830        840
SLVKKHKDVA EEIANYRPTL DTLHEQASAL PQEHAESPDV RGRLSGIEER YKEVAELTRL
       850        860        870        880        890        900
RKQALQDTLA LYKMFSEADA CELWIDEKEQ WLNNMQIPEK LEDLEVIQHR FESLEPEMNN
       910        920        930        940        950        960
QASRVAVVNQ IARQLMHSGH PSEKEIKAQQ DKLNTRWSQF RELVDRKKDA LLSALSIQNY
       970        980        990       1000       1010       1020
HLECNETKSW IREKTKVIES TQDLGNDLAG VMALQRKLTG MERDLVAIEA KLSDLQKEAE
      1030       1040       1050       1060       1070       1080
KLESEHPDQA QAILSRLAEI SDVWEEMKTT LKNREASLGE ASKLQQFLRD LDDFQSWLSR
      1090       1100       1110       1120       1130       1140
TQTAIASEDM PNTLTEAEKL LTQHENIKNE IDNYEEDYQK MRDMGEMVTQ GQTDAQYMFL
      1150       1160       1170       1180       1190       1200
RQRLQALDTG WNELHKMWEN RQNLLSQSHA YQQFLRDTKQ AEAFLNNQEY VLAHTEMPTT
      1210       1220       1230       1240       1250       1260
LEGAEAAIKK QEDFMTTMDA NEEKINAVVE TGRRLVSDGN INSDRIQEKV DSIDDRHRKN
      1270       1280       1290       1300       1310       1320
RETASELLMR LKDNRDLQKF LQDCQELSLW INEKMLTAQD MSYDEARNLH SKWLKHQAFM
      1330       1340       1350       1360       1370       1380
AELASNKEWL DKIEKEGMQL ISEKPETEAV VKEKLTGLHK MWEVLESTTQ TKAQRLFDAN
      1390       1400       1410       1420       1430       1440
KAELFTQSCA DLDKWLHGLE SQIQSDDYGK DLTSVNILLK KQQMLENQME VRKKEIEELQ
      1450       1460       1470       1480       1490       1500
SQAQALSQEG KSTDEVDSKR LTVQTKFMEL LEPLNERKHN LLASKEIHQF NRDVEDEILW
      1510       1520       1530       1540       1550       1560
VGERMPLATS TDHGHNLQTV QLLIKKNQTL QKEIQGHQPR IDDIFERSQN IVTDSSSLSA
      1570       1580       1590       1600       1610       1620
EAIRQRLADL KQLWGLLIEE TEKRHRRLEE AHRAQQYYFD AAEAEAWMSE QELYMMSEEK
      1630       1640       1650       1660       1670       1680
AKDEQSAVSM LKKHQILEQA VEDYAETVHQ LSKTSRALVA DSHPESERIS MRQSKVDKLY
      1690       1700       1710       1720       1730       1740
AGLKDLAEER RGKLDERHRL FQLNREVDDL EQWIAEREVV AGSHELGQDY EHVTMLQERF
      1750       1760       1770       1780       1790       1800
REFARDTGNI GQERVDTVNH LADELINSGH SDAATIAEWK DGLNEAWADL LELIDTRTQI
      1810       1820       1830       1840       1850       1860
LAASYELHKF YHDAKEIFGR IQDKHKKLPE ELGRDQNTVE TLQRMHTTFE HDIQALGTQV
      1870       1880       1890       1900       1910       1920
RQLQEDAARL QAAYAGDKAD DIQKRENEVL EAWKSLLDAC ESRRVRLVDT GDKFRFFSMV
      1930       1940       1950       1960       1970       1980
RDLMLWMEDV IRQIEAQEKP RDVSSVELLM NNHQGIKAEI DARNDSFTTC IELGKSLLAR
      1990       2000       2010       2020       2030       2040
KHYASEEIKE KLLQLTEKRK EMIDKWEDRW EWLRLILEVH QFSRDASVAE AWLLGQEPYL
      2050       2060       2070       2080       2090       2100
SSREIGQSVD EVEKLIKRHE AFEKSAATWD ERFSALERLT TLELLEVRRQ QEEEERKRRP
      2110       2120       2130       2140       2150       2160
PSPEPSTKVS EEAESQQQWD TSKGEQVSQN GLPAEQGSPR MAETVDTSEM VNGATEQRTS
      2170       2180       2190       2200       2210       2220
SKESSPIPSP TSDRKAKTAL PAQSAATLPA RTQETPSAQM EGFLNRKHEW EAHNKKASSR
      2230       2240       2250       2260       2270       2280
SWHNVYCVIN NQEMGFYKDA KTAASGIPYH SEVPVSLKEA VCEVALDYKK KKHVFKLRLN
      2290       2300       2310       2320       2330       2340
DGNEYLFQAK DDEEMNTWIQ AISSAISSDK HEVSASTQST PASSRAQTLP TSVVTITSES
      2350       2360
SPGKREKDKE KDKEKRFSLF GKKK         10         20         30         40         50         60
MTTTVATDYD NIEIQQQYSD VNNRWDVDDW DNENSSARLF ERSRIKALAD EREAVQKKTF
        70         80         90        100        110        120
TKWVNSHLAR VSCRITDLYT DLRDGRMLIK LLEVLSGERL PKPTKGRMRI HCLENVDKAL
       130        140        150        160        170        180
QFLKEQRVHL ENMGSHDIVD GNHRLTLGLI WTIILRFQIQ DISVETEDNK EKKSAKDALL
       190        200        210        220        230        240
LWCQMKTAGY PNVNIHNFTT SWRDGMAFNA LIHKHRPDLI DFDKLKKSNA HYNLQNAFNL
       250        260        270        280        290        300
AEQHLGLTKL LDPEDISVDH PDEKSIITYV VTYYHYFSKM KALAVEGKRI GKVLDNAIET
       310        320        330        340        350        360
EKMIEKYESL ASDLLEWIEQ TIIILNNRKF ANSLVGVQQQ LQAFNTYRTV EKPPKFTEKG
       370        380        390        400        410        420
NLEVLLFTIQ SKMRANNQKV YMPREGKLIS DINKAWERLE KAEHERELAL RNELIRQEKL
       430        440        450        460        470        480
EQLARRFDRK AAMRETWLSE NQRLVSQDNF GFDLPAVEAA TKKHEAIETD IAAYEERVQA
       490        500        510        520        530        540
VVAVARELEA ENYHDIKRIT ARKDNVIRLW EYLLELLRAR RQRLEMNLGL QKIFQEMLYI
       550        560        570        580        590        600
MDWMDEMKVL VLSQDYGKHL LGVEDLLQKH TLVEADIGIQ AERVRGVNAS AQKFATDGEG
       610        620        630        640        650        660
YKPCDPQVIR DRVAHMEFCY QELCQLAAER RARLEESRRL WKFFWEMAEE EGWIREKEKI
       670        680        690        700        710        720
LSSDDYGKDL TSVMRLLSKH RAFEDEMSGR SGHFEQAIKE GEDMIAEEHF GSEKIRERII
       730        740        750        760        770        780
YIREQWANLE QLSAIRKKRL EEASLLHQFQ ADADDIDAWM LDILKIVSSS DVGHDEYSTQ
       790        800        810        820        830        840
SLVKKHKDVA EEIANYRPTL DTLHEQASAL PQEHAESPDV RGRLSGIEER YKEVAELTRL
       850        860        870        880        890        900
RKQALQDTLA LYKMFSEADA CELWIDEKEQ WLNNMQIPEK LEDLEVIQHR FESLEPEMNN
       910        920        930        940        950        960
QASRVAVVNQ IARQLMHSGH PSEKEIKAQQ DKLNTRWSQF RELVDRKKDA LLSALSIQNY
       970        980        990       1000       1010       1020
HLECNETKSW IREKTKVIES TQDLGNDLAG VMALQRKLTG MERDLVAIEA KLSDLQKEAE
      1030       1040       1050       1060       1070       1080
KLESEHPDQA QAILSRLAEI SDVWEEMKTT LKNREASLGE ASKLQQFLRD LDDFQSWLSR
      1090       1100       1110       1120       1130       1140
TQTAIASEDM PNTLTEAEKL LTQHENIKNE IDNYEEDYQK MRDMGEMVTQ GQTDAQYMFL
      1150       1160       1170       1180       1190       1200
RQRLQALDTG WNELHKMWEN RQNLLSQSHA YQQFLRDTKQ AEAFLNNQEY VLAHTEMPTT
      1210       1220       1230       1240       1250       1260
LEGAEAAIKK QEDFMTTMDA NEEKINAVVE TGRRLVSDGN INSDRIQEKV DSIDDRHRKN
      1270       1280       1290       1300       1310       1320
RETASELLMR LKDNRDLQKF LQDCQELSLW INEKMLTAQD MSYDEARNLH SKWLKHQAFM
      1330       1340       1350       1360       1370       1380
AELASNKEWL DKIEKEGMQL ISEKPETEAV VKEKLTGLHK MWEVLESTTQ TKAQRLFDAN
      1390       1400       1410       1420       1430       1440
KAELFTQSCA DLDKWLHGLE SQIQSDDYGK DLTSVNILLK KQQMLENQME VRKKEIEELQ
      1450       1460       1470       1480       1490       1500
SQAQALSQEG KSTDEVDSKR LTVQTKFMEL LEPLNERKHN LLASKEIHQF NRDVEDEILW
      1510       1520       1530       1540       1550       1560
VGERMPLATS TDHGHNLQTV QLLIKKNQTL QKEIQGHQPR IDDIFERSQN IVTDSSSLSA
      1570       1580       1590       1600       1610       1620
EAIRQRLADL KQLWGLLIEE TEKRHRRLEE AHRAQQYYFD AAEAEAWMSE QELYMMSEEK
      1630       1640       1650       1660       1670       1680
AKDEQSAVSM LKKHQILEQA VEDYAETVHQ LSKTSRALVA DSHPESERIS MRQSKVDKLY
      1690       1700       1710       1720       1730       1740
AGLKDLAEER RGKLDERHRL FQLNREVDDL EQWIAEREVV AGSHELGQDY EHVTMLQERF
      1750       1760       1770       1780       1790       1800
REFARDTGNI GQERVDTVNH LADELINSGH SDAATIAEWK DGLNEAWADL LELIDTRTQI
      1810       1820       1830       1840       1850       1860
LAASYELHKF YHDAKEIFGR IQDKHKKLPE ELGRDQNTVE TLQRMHTTFE HDIQALGTQV
      1870       1880       1890       1900       1910       1920
RQLQEDAARL QAAYAGDKAD DIQKRENEVL EAWKSLLDAC ESRRVRLVDT GDKFRFFSMV
      1930       1940       1950       1960       1970       1980
RDLMLWMEDV IRQIEAQEKP RDVSSVELLM NNHQGIKAEI DARNDSFTTC IELGKSLLAR
      1990       2000       2010       2020       2030       2040
KHYASEEIKE KLLQLTEKRK EMIDKWEDRW EWLRLILEVH QFSRDASVAE AWLLGQEPYL
      2050       2060       2070       2080       2090       2100
SSREIGQSVD EVEKLIKRHE AFEKSAATWD ERFSALERLT TLELLEVRRQ QEEEERKRRP
      2110       2120       2130       2140       2150       2160
PSPEPSTKVS EEAESQQQWD TSKGEQVSQN GLPAEQGSPR MAETVDTSEM VNGATEQRTS
      2170       2180       2190       2200       2210       2220
SKESSPIPSP TSDRKAKTAL PAQSAATLPA RTQETPSAQM EGFLNRKHEW EAHNKKASSR
      2230       2240       2250       2260       2270       2280
SWHNVYCVIN NQEMGFYKDA KTAASGIPYH SEVPVSLKEA VCEVALDYKK KKHVFKLRLN
      2290       2300       2310       2320       2330       2340
DGNEYLFQAK DDEEMNTWIQ AISSAISSDK HEVSASTQST PASSRAQTLP TSVVTITSES
      2350       2360
SPGKREKDKE KDKEKRFSLF GKKK

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

19 N-termini - 8 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q01082-2-unknown	MTTTVA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q01082-1-unknown	MTTTVA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt90565
Q01082-2-Acetylation	TTTVAT...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q01082-2-Acetylation	TTTVAT...	2	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
Q01082-2-Acetylation	TTTVAT...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110558
Q01082-697-unknown	AIKEGE...	697		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173556
Q01082-697-unknown	AIKEGE...	697		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173557
Q01082-697-	AIKEGE...	697			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q01082-1042-unknown	DVWEEM...	1042		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19311
Q01082-1042-unknown	DVWEEM...	1042		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157223
Q01082-1042-unknown	DVWEEM...	1042		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt157253
Q01082-1106-unknown	NIKNEI...	1106		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173553
Q01082-1106-unknown	NIKNEI...	1106		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt173554
Q01082-1106-	NIKNEI...	1106			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q01082-1458-unknown	SKRLTV...	1458		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2000
Q01082-1458-unknown	SKRLTV...	1458		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158115
Q01082-1458-unknown	SKRLTV...	1458		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158125
Q01082-1465-unknown	TKFMEL...	1465		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17826
Q01082-1465-unknown	TKFMEL...	1465		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158121
Q01082-1465-unknown	TKFMEL...	1465		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158163
Q01082-1575-unknown	GLLIEE...	1575		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17829
Q01082-1575-unknown	GLLIEE...	1575		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158277
Q01082-1575-unknown	GLLIEE...	1575		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158294
Q01082-2067-unknown	ATWDER...	2067		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC801
Q01082-2067-unknown	ATWDER...	2067		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158862
Q01082-2067-unknown	ATWDER...	2067		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt158878
Q01082-2131-	GLPAEQ...	2131			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q01082-2131-	GLPAEQ...	2131			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q01082-2147-	TSEMVN...	2147			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q01082-2147-	TSEMVN...	2147			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
Q01082-2147-unknown	TSEMVN...	2147		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2003
Q01082-2150-	MVNGAT...	2150			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q01082-2176-unknown	AKTALP...	2176			unknown			Mahrus S. et al.: nonapototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
Q01082-2176-	AKTALP...	2176			Subtiligase Based Positive Selection		Wells	Jurkat_untreated	23264352
Q01082-2184-	SAATLP...	2184			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...LAEISD	1041	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC19311
...LAEISD	1041	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt140722
...LAEISD	1041	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt140752
...TDEVDS	1457	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2000
...TDEVDS	1457	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt141610
...TDEVDS	1457	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt141620
...RLTVQT	1464	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17826
...RLTVQT	1464	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt141616
...RLTVQT	1464	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt141659
...LKQLWG	1574	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC17829
...LKQLWG	1574	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt141773
...LKQLWG	1574	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt141791
...FEKSAA	2066	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC801
...FEKSAA	2066	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt142366
...FEKSAA	2066	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt142382
...AETVDT	2146	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2003
...FGKKK	2364	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...FGKKK	2364		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...FGKKK	2364		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...FGKKK	2364		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...FGKKK	2364		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MEP1B_HUMAN	1041	EISD.\|.DVWE	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CASP3_HUMAN	1457	EVDS.\|.SKRL	inferred from experiment	unknown	MEROPS	Morrow JS	Wang KK et al.:Simultaneous degradation of alp... (C14.003)	9712874,
MEP1A_HUMAN	1464	TVQT.\|.TKFM	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
MEP1A_HUMAN	1574	QLWG.\|.GLLI	inferred from experiment	unknown	MEROPS	Overall CM	Becker-Pauly C et al.:Proteomic analyses reveal an ac... (M12.002)	21693781,
CAN1_HUMAN	2066	KSAA.\|.ATWD	inferred from experiment	unknown	MEROPS	Backman L	Lofvenberg L et al.:Calpain-induced proteolysis of ... (C02.001)	9989581,
CASP3_HUMAN	2146	TVDT.\|.TSEM	inferred from experiment	unknown	MEROPS	Morrow JS	Wang KK et al.:Simultaneous degradation of alp... (C14.003)	9712874,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)