P61586: Transforming protein RhoA {ECO:0000305}

General Information

Protein names	- Transforming protein RhoA {ECO:0000305} - 3.6.5.2 {ECO:0000269\|PubMed:21565175, ECO:0000269\|PubMed:23940119} - Rho cDNA clone 12 - h12
Gene names	RHOA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P61586

6 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAAIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYVADIEVDG KQVELALWDT
        70         80         90        100        110        120
AGQEDYDRLR PLSYPDTDVI LMCFSIDSPD SLENIPEKWT PEVKHFCPNV PIILVGNKKD
       130        140        150        160        170        180
LRNDEHTRRE LAKMKQEPVK PEEGRDMANR IGAFGYMECS AKTKDGVREV FEMATRAALQ
       190
ARRGKKKSGC LVL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P61586-1-unknown	MAAIRK...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P61586-18-unknown	KTCLLI...	18	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC14239
P61586-42-	YVADIE...	42		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_staurotrail	23264352
P61586-42-	YVADIE...	42		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P61586-42-	YVADIE...	42		Subtiligase Based Positive Selection		Wells	MM1SDBJurkat_Untreated	23264352
P61586-85-	SIDSPD...	85		Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
P61586-134-	MKQEPV...	134		Subtiligase Based Positive Selection		Wells	DB_Untreated	23264352
P61586-134-	MKQEPV...	134		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
P61586-181-unknown	ARRGKK...	181	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC800

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DGACGK	17	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC14239
...EHTRRE	129	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000408402
...RAALQA	180	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC800
...KKSGCL	190	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KKSGCL	190	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9649

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
GRAM_HUMAN	17	ACGK.\|.KTCL	inferred from experiment	unknown	MEROPS	Bovenschen N	de Poot SA et al.:Human and mouse granzyme M disp... (S01.139)	21564021,
CAN1_HUMAN	180	ALQA.\|.ARRG	inferred from experiment	unknown	MEROPS	Fox JE	Kulkarni S et al.:Calpain cleaves RhoA generating... (C02.001)	11964413,
FACE2_HUMAN	190	SGCL.\|.LVL	inferred from experiment	unknown	MEROPS	Schmidt G	Fueller F et al.:Endoproteolytic processing of R... (M79.002)	16495543,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)