Q07817: Bcl-2-like protein 1

General Information

Protein names	- Bcl-2-like protein 1 - Bcl2-L-1 - Apoptosis regulator Bcl-X
Gene names	BCL2L1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q07817

6 N-termini

4 C-termini

4 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Bcl-X(S) of Bcl-2-like protein 1 - Isoform Bcl-X(beta) of Bcl-2-like protein 1

Sequence View

        10         20         30         40         50         60
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA INGNPSWHLA
        70         80         90        100        110        120
DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY
       130        140        150        160        170        180
QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP
       190        200        210        220        230
WIQENGGWDT FVELYGNNAA AESRKGQERF NRWFLTGMTV AGVVLLGSLF SRK         10         20         30         40         50         60
MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEG TESEMETPSA INGNPSWHLA
        70         80         90        100        110        120
DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY
       130        140        150        160        170        180
QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL CVESVDKEMQ VLVSRIAAWM ATYLNDHLEP
       190        200        210        220        230
WIQENGGWDT FVELYGNNAA AESRKGQERF NRWFLTGMTV AGVVLLGSLF SRK

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 4 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q07817-1-unknown	MSQSNR...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q07817-1-unknown	MSQSNR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68055
Q07817-1-unknown	MSQSNR...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt68056
Q07817-43-unknown	SEMETP...	43	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC820
Q07817-43-unknown	SEMETP...	43	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138574
Q07817-43-unknown	SEMETP...	43	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138576
Q07817-62-unknown	SPAVNG...	62	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2091
Q07817-62-unknown	SPAVNG...	62	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1277
Q07817-62-unknown	SPAVNG...	62	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140067
Q07817-62-unknown	SPAVNG...	62	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140069
Q07817-64-unknown	AVNGAT...	64	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165229
Q07817-64-unknown	AVNGAT...	64	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt165230
Q07817-64-	AVNGAT...	64		Subtiligase Based Positive Selection		Wells	apoptotic_DB_Doxo	23264352
Q07817-64-	AVNGAT...	64		Subtiligase Based Positive Selection		Wells	apoptotic_RPMI_Dox	23264352
Q07817-64-	AVNGAT...	64		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
Q07817-77-unknown	AREVIP...	77	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2094
Q07817-77-unknown	AREVIP...	77	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141091
Q07817-77-unknown	AREVIP...	77	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141092

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PEGTES	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC820
...PEGTES	42	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121624
...PEGTES	42	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121626
...WHLADS	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2091
...WHLADS	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1277
...WHLADS	61	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123174
...WHLADS	61	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123176
...SSSLDA	76	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2094
...SSSLDA	76	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124244
...SSSLDA	76	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124245
...LFSRK	233	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LFSRK	233	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63673

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CAN1_HUMAN	42	GTES.\|.SEME	inferred from experiment	unknown	MEROPS	Machleidt W	Gil-Parrado S et al.:Ionomycin-activated calpain tri... (C02.001)	12000759,
CASP3_HUMAN	61	LADS.\|.SPAV	inferred from experiment	unknown	MEROPS	Hardwick JM	Bellows DS et al.:Antiapoptotic herpesvirus Bcl-2... (C14.003)	10799576,
CASP1_HUMAN	61	LADS.\|.SPAV	inferred from experiment	unknown	MEROPS	Hardwick JM	Clem RJ et al.:Modulation of cell death by Bcl... (C14.001)	9435230,
CASP3_HUMAN	76	SLDA.\|.AREV	inferred from experiment	unknown	MEROPS	Hardwick JM	Bellows DS et al.:Antiapoptotic herpesvirus Bcl-2... (C14.003)	10799576,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)