Q08209: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

General Information

Protein names	- Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform - 3.1.3.16 {ECO:0000269\|PubMed:15671020, ECO:0000269\|PubMed:18838687, ECO:0000269\|PubMed:19154138, ECO:0000269\|PubMed:23468591, ECO:0000305\|PubMed:26248042} - CAM-PRP catalytic subunit - Calmodulin-dependent calcineurin A subunit alpha isoform
Gene names	PPP3CA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q08209

7 N-termini

5 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform - Isoform 3 of Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform - Isoform 4 of Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform - Isoform 5 of Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Sequence View

        10         20         30         40         50         60
MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL MKEGRLEESV
        70         80         90        100        110        120
ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV
       130        140        150        160        170        180
DRGYFSIECV LYLWALKILY PKTLFLLRGN HECRHLTEYF TFKQECKIKY SERVYDACMD
       190        200        210        220        230        240
AFDCLPLAAL MNQQFLCVHG GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG
       250        260        270        280        290        300
NEKTQEHFTH NTVRGCSYFY SYPAVCEFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP
       310        320        330        340        350        360
SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK
       370        380        390        400        410        420
VTEMLVNVLN ICSDDELGSE EDGFDGATAA ARKEVIRNKI RAIGKMARVF SVLREESESV
       430        440        450        460        470        480
LTLKGLTPTG MLPSGVLSGG KQTLQSATVE AIEADEAIKG FSPQHKITSF EEAKGLDRIN
       490        500        510        520
ERMPPRRDAM PSDANLNSIN KALTSETNGT DSNGSNSSNI Q         10         20         30         40         50         60
MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL MKEGRLEESV
        70         80         90        100        110        120
ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV
       130        140        150        160        170        180
DRGYFSIECV LYLWALKILY PKTLFLLRGN HECRHLTEYF TFKQECKIKY SERVYDACMD
       190        200        210        220        230        240
AFDCLPLAAL MNQQFLCVHG GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG
       250        260        270        280        290        300
NEKTQEHFTH NTVRGCSYFY SYPAVCEFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP
       310        320        330        340        350        360
SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK
       370        380        390        400        410        420
VTEMLVNVLN ICSDDELGSE EDGFDGATAA ARKEVIRNKI RAIGKMARVF SVLREESESV
       430        440        450        460        470        480
LTLKGLTPTG MLPSGVLSGG KQTLQSATVE AIEADEAIKG FSPQHKITSF EEAKGLDRIN
       490        500        510        520
ERMPPRRDAM PSDANLNSIN KALTSETNGT DSNGSNSSNI Q         10         20         30         40         50         60
MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL MKEGRLEESV
        70         80         90        100        110        120
ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV
       130        140        150        160        170        180
DRGYFSIECV LYLWALKILY PKTLFLLRGN HECRHLTEYF TFKQECKIKY SERVYDACMD
       190        200        210        220        230        240
AFDCLPLAAL MNQQFLCVHG GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG
       250        260        270        280        290        300
NEKTQEHFTH NTVRGCSYFY SYPAVCEFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP
       310        320        330        340        350        360
SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK
       370        380        390        400        410        420
VTEMLVNVLN ICSDDELGSE EDGFDGATAA ARKEVIRNKI RAIGKMARVF SVLREESESV
       430        440        450        460        470        480
LTLKGLTPTG MLPSGVLSGG KQTLQSATVE AIEADEAIKG FSPQHKITSF EEAKGLDRIN
       490        500        510        520
ERMPPRRDAM PSDANLNSIN KALTSETNGT DSNGSNSSNI Q         10         20         30         40         50         60
MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL MKEGRLEESV
        70         80         90        100        110        120
ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV
       130        140        150        160        170        180
DRGYFSIECV LYLWALKILY PKTLFLLRGN HECRHLTEYF TFKQECKIKY SERVYDACMD
       190        200        210        220        230        240
AFDCLPLAAL MNQQFLCVHG GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG
       250        260        270        280        290        300
NEKTQEHFTH NTVRGCSYFY SYPAVCEFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP
       310        320        330        340        350        360
SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK
       370        380        390        400        410        420
VTEMLVNVLN ICSDDELGSE EDGFDGATAA ARKEVIRNKI RAIGKMARVF SVLREESESV
       430        440        450        460        470        480
LTLKGLTPTG MLPSGVLSGG KQTLQSATVE AIEADEAIKG FSPQHKITSF EEAKGLDRIN
       490        500        510        520
ERMPPRRDAM PSDANLNSIN KALTSETNGT DSNGSNSSNI Q

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

7 N-termini - 5 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q08209-2-unknown	MSEPKA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q08209-1-unknown	MSEPKA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85850
Q08209-1-unknown	MSEPKA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85851
Q08209-1-unknown	MSEPKA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt85852
Q08209-2-Acetylation	SEPKAI...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q08209-2-Acetylation	SEPKAI...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q08209-2-Acetylation	SEPKAI...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q08209-2-Acetylation	SEPKAI...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110137
Q08209-2-Acetylation	SEPKAI...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110138
Q08209-2-Acetylation	SEPKAI...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110139
Q08209-51-unknown	MKEGRL...	51		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000431619
Q08209-51-unknown	MKEGRL...	51		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000434599
Q08209-51-unknown	MKEGRL...	51		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196140
Q08209-51-unknown	MKEGRL...	51		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196141
Q08209-51-unknown	MKEGRL...	51		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196142
Q08209-99-unknown	MKLFEV...	99		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000422990
Q08209-99-unknown	MKLFEV...	99		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196931
Q08209-99-unknown	MKLFEV...	99		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196932
Q08209-99-unknown	MKLFEV...	99		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196933
Q08209-386-unknown	GATAAA...	386		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2115
Q08209-386-unknown	GATAAA...	386		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2945
Q08209-386-unknown	GATAAA...	386		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt144888
Q08209-386-unknown	GATAAA...	386		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150300
Q08209-386-unknown	GATAAA...	386		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt150821
Q08209-386-unknown	GATAAA...	386		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt151756
Q08209-502-unknown	ALTSET...	502		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC823
Q08209-502-unknown	ALTSET...	502		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt149112
Q08209-502-unknown	ALTSET...	502		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152548
Q08209-502-unknown	ALTSET...	502		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt152787
Q08209-502-unknown	ALTSET...	502		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt153324

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...CMDAFD	182	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000434599
...CMDAFD	182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155415
...CMDAFD	182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155416
...CMDAFD	182	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155417
...QQFLCV	197	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000431619
...QQFLCV	197	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155578
...QQFLCV	197	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155579
...QQFLCV	197	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155580
...EDGFDG	385	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2115
...EDGFDG	385	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2945
...EDGFDG	385	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128165
...EDGFDG	385	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133695
...EDGFDG	385	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134223
...EDGFDG	385	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135161
...NSINKA	501	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC823
...NSINKA	501	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132497
...NSINKA	501	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135962
...NSINKA	501	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136210
...NSINKA	501	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt136748
...SSNIQ	521	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SSNIQ	521	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81470
...SSNIQ	521	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81471
...SSNIQ	521	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81469
...SSNIQ	521	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81468

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	385	GFDG.\|.GATA	inferred from experiment	unknown	MEROPS	Wang KK	Mukerjee N et al.:Caspase-mediated proteolytic ac... (C14.003)	10898953,
CASP7_HUMAN	385	GFDG.\|.GATA	inferred from experiment	unknown	MEROPS	Wang KK	Mukerjee N et al.:Caspase-mediated proteolytic ac... (C14.003)	10898953,
CAN1_HUMAN	501	INKA.\|.ALTS	inferred from experiment	unknown	MEROPS	Gong CX	Liu F et al.:Truncation and activation of ca... (C02.001)	16150694,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)