TopFIND 4.0

P24593: Insulin-like growth factor-binding protein 5

General Information

Protein names	- Insulin-like growth factor-binding protein 5 - IBP-5 - IGF-binding protein 5 - IGFBP-5
Gene names	IGFBP5
Organism	Homo sapiens
Protease Family
Protease ID	I31.952
Chromosome location
UniProt ID	P24593

14 N-termini

13 C-termini

15 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MVLLTAVLLL LAAYAGPAQS LGSFVHCEPC DEKALSMCPP SPLGCELVKE PGCGCCMTCA
        70         80         90        100        110        120
LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC LNEKSYREQV KIERDSREHE
       130        140        150        160        170        180
EPTTSEMAEE TYSPKIFRPK HTRISELKAE AVKKDRRKKL TQSKFVGGAE NTAHPRIISA
       190        200        210        220        230        240
PEMRQESEQG PCRRHMEASL QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI
       250        260        270
CWCVDKYGMK LPGMEYVDGD FQCHTFDSSN VE

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

14 N-termini - 13 C-termini - 15 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P24593-21-unknown	LGSFVH...	21	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P24593-23-unknown	SFVHCE...	23	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC745
P24593-25-unknown	VHCEPC...	25		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P24593-28-unknown	EPCDEK...	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16459
P24593-136-unknown	IFRPKH...	136	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16807
P24593-141-unknown	HTRISE...	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31772
P24593-141-unknown	HTRISE...	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16808
P24593-144-unknown	ISELKA...	144	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16460
P24593-162-unknown	QSKFVG...	162	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC746
P24593-164-unknown	KFVGGA...	164	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26782
P24593-164-unknown	KFVGGA...	164	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26785
P24593-165-unknown	FVGGAE...	165	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26783
P24593-173-unknown	AHPRII...	173	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC747
P24593-177-unknown	IISAPE...	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31773
P24593-177-unknown	IISAPE...	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16809
P24593-209-unknown	MVPRAV...	209		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P24593-213-unknown	AVYLPN...	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31774
P24593-213-unknown	AVYLPN...	213	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16461
P24593-213-unknown	AVYLPN...	213		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...AQSLGS	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC745
...SFVHCE	27	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16459
...TYSPKI	135	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16807
...IFRPKH	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31772
...IFRPKH	140	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16808
...PKHTRI	143	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16460
...RKKLTQ	161	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC746
...KLTQSK	163	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26782
...KLTQSK	163	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26785
...LTQSKF	164	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26783
...GAENTA	172	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC747
...TAHPRI	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31773
...TAHPRI	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16809
...RQESEQ	188	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000413474
...RMVPRA	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31774
...RMVPRA	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16461
...SSNVE	272	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CAN1_HUMAN	22	SLGS.\|.SFVH	inferred from experiment	unknown	MEROPS		Merops CAN1_HUMAN -> IBP5_HUMAN @22
KLK5_HUMAN	27	VHCE.\|.EPCD	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Human tissue kallikrein 5 is a ... (S01.017)	16517595,
MASP1_HUMAN	135	SPKI.\|.IFRP	inferred from experiment	unknown	MEROPS	Jiang W	Cortesio CL et al.:Mannan-binding lectin-associate... (S01.132)	16554018,
THRB_HUMAN	140	RPKH.\|.HTRI	inferred from experiment	unknown	MEROPS	Clemmons DR	Zheng B et al.:Insulin-like growth factor-bind... (S01.217)	9528953,
MASP1_HUMAN	140	RPKH.\|.HTRI	inferred from experiment	unknown	MEROPS	Jiang W	Cortesio CL et al.:Mannan-binding lectin-associate... (S01.132)	16554018,
KLK5_HUMAN	143	HTRI.\|.ISEL	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Human tissue kallikrein 5 is a ... (S01.017)	16517595,
CAN1_HUMAN	161	KLTQ.\|.QSKF	inferred from experiment	unknown	MEROPS		Merops CAN1_HUMAN -> IBP5_HUMAN @161
PAPP1_HUMAN	163	TQSK.\|.KFVG	inferred from experiment	unknown	MEROPS	Oxvig C	Laursen LS et al.:Pregnancy-associated plasma pro... (M43.004)	11522292,
PAPP2_HUMAN	163	TQSK.\|.KFVG	inferred from experiment	unknown	MEROPS	Oxvig C	Overgaard MT et al.:Pregnancy-associated plasma pro... (M43.005)	11264294,
PAPP1_HUMAN	164	QSKF.\|.FVGG	inferred from experiment	unknown	MEROPS	Oxvig C	Laursen LS et al.:Pregnancy-associated plasma pro... (M43.004)	11522292,
CAN1_HUMAN	172	ENTA.\|.AHPR	inferred from experiment	unknown	MEROPS		Merops CAN1_HUMAN -> IBP5_HUMAN @172
THRB_HUMAN	176	HPRI.\|.IISA	inferred from experiment	unknown	MEROPS	Clemmons DR	Zheng B et al.:Insulin-like growth factor-bind... (S01.217)	9528953,
MASP1_HUMAN	176	HPRI.\|.IISA	inferred from experiment	unknown	MEROPS	Jiang W	Cortesio CL et al.:Mannan-binding lectin-associate... (S01.132)	16554018,
THRB_HUMAN	212	VPRA.\|.AVYL	inferred from experiment	unknown	MEROPS	Clemmons DR	Zheng B et al.:Insulin-like growth factor-bind... (S01.217)	9528953,
KLK5_HUMAN	212	VPRA.\|.AVYL	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Human tissue kallikrein 5 is a ... (S01.017)	16517595,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)