Q13219: Pappalysin-1
| Protein names | - Pappalysin-1 - 3.4.24.79 - Insulin-like growth factor-dependent IGF-binding protein 4 protease - IGF-dependent IGFBP-4 protease - IGFBP-4ase - Pregnancy-associated plasma protein A - PAPP-A |
|---|---|
| Gene names | PAPPA |
| Organism | Homo sapiens |
| Protease Family | M43.004 |
| Protease ID | M43.004 |
| Chromosome location | |
| UniProt ID | Q13219 |
5
N-termini
3
C-termini
2
Cleavages
4
Substrates
Sequence
10 20 30 40 50 60
MRLWSWVLHL GLLSAALGCG LAERPRRARR DPRAGRPPRP AAGPATCATR AARGRRASPP
70 80 90 100 110 120
PPPPPGGAWE AVRVPRRRQQ REARGATEEP SPPSRALYFS GRGEQLRLRA DLELPRDAFT
130 140 150 160 170 180
LQVWLRAEGG QRSPAVITGL YDKCSYISRD RGWVVGIHTI SDQDNKDPRY FFSLKTDRAR
190 200 210 220 230 240
QVTTINAHRS YLPGQWVYLA ATYDGQFMKL YVNGAQVATS GEQVGGIFSP LTQKCKVLML
250 260 270 280 290 300
GGSALNHNYR GYIEHFSLWK VARTQREILS DMETHGAHTA LPQLLLQENW DNVKHAWSPM
310 320 330 340 350 360
KDGSSPKVEF SNAHGFLLDT SLEPPLCGQT LCDNTEVIAS YNQLSSFRQP KVVRYRVVNL
370 380 390 400 410 420
YEDDHKNPTV TREQVDFQHH QLAEAFKQYN ISWELDVLEV SNSSLRRRLI LANCDISKIG
430 440 450 460 470 480
DENCDPECNH TLTGHDGGDC RHLRHPAFVK KQHNGVCDMD CNYERFNFDG GECCDPEITN
490 500 510 520 530 540
VTQTCFDPDS PHRAYLDVNE LKNILKLDGS THLNIFFAKS SEEELAGVAT WPWDKEALMH
550 560 570 580 590 600
LGGIVLNPSF YGMPGHTHTM IHEIGHSLGL YHVFRGISEI QSCSDPCMET EPSFETGDLC
610 620 630 640 650 660
NDTNPAPKHK SCGDPGPGND TCGFHSFFNT PYNNFMSYAD DDCTDSFTPN QVARMHCYLD
670 680 690 700 710 720
LVYQGWQPSR KPAPVALAPQ VLGHTTDSVT LEWFPPIDGH FFERELGSAC HLCLEGRILV
730 740 750 760 770 780
QYASNASSPM PCSPSGHWSP REAEGHPDVE QPCKSSVRTW SPNSAVNPHT VPPACPEPQG
790 800 810 820 830 840
CYLELEFLYP LVPESLTIWV TFVSTDWDSS GAVNDIKLLA VSGKNISLGP QNVFCDVPLT
850 860 870 880 890 900
IRLWDVGEEV YGIQIYTLDE HLEIDAAMLT STADTPLCLQ CKPLKYKVVR DPPLQMDVAS
910 920 930 940 950 960
ILHLNRKFVD MDLNLGSVYQ YWVITISGTE ESEPSPAVTY IHGSGYCGDG IIQKDQGEQC
970 980 990 1000 1010 1020
DDMNKINGDG CSLFCRQEVS FNCIDEPSRC YFHDGDGVCE EFEQKTSIKD CGVYTPQGFL
1030 1040 1050 1060 1070 1080
DQWASNASVS HQDQQCPGWV IIGQPAASQV CRTKVIDLSE GISQHAWYPC TISYPYSQLA
1090 1100 1110 1120 1130 1140
QTTFWLRAYF SQPMVAAAVI VHLVTDGTYY GDQKQETISV QLLDTKDQSH DLGLHVLSCR
1150 1160 1170 1180 1190 1200
NNPLIIPVVH DLSQPFYHSQ AVRVSFSSPL VAISGVALRS FDNFDPVTLS SCQRGETYSP
1210 1220 1230 1240 1250 1260
AEQSCVHFAC EKTDCPELAV ENASLNCSSS DRYHGAQCTV SCRTGYVLQI RRDDELIKSQ
1270 1280 1290 1300 1310 1320
TGPSVTVTCT EGKWNKQVAC EPVDCSIPDH HQVYAASFSC PEGTTFGSQC SFQCRHPAQL
1330 1340 1350 1360 1370 1380
KGNNSLLTCM EDGLWSFPEA LCELMCLAPP PVPNADLQTA RCRENKHKVG SFCKYKCKPG
1390 1400 1410 1420 1430 1440
YHVPGSSRKS KKRAFKTQCT QDGSWQEGAC VPVTCDPPPP KFHGLYQCTN GFQFNSECRI
1450 1460 1470 1480 1490 1500
KCEDSDASQG LGSNVIHCRK DGTWNGSFHV CQEMQGQCSV PNELNSNLKL QCPDGYAIGS
1510 1520 1530 1540 1550 1560
ECATSCLDHN SESIILPMNV TVRDIPHWLN PTRVERVVCT AGLKWYPHPA LIHCVKGCEP
1570 1580 1590 1600 1610 1620
FMGDNYCDAI NNRAFCNYDG GDCCTSTVKT KKVTPFPMSC DLQGDCACRD PQAQEHSRKD
LRGYSHG
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
5 N-termini - 3 C-termini - 2 Cleavages - 4 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q13219-23-unknown | ERPRRA... | 23 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q13219-81-unknown | REARGA... | 81 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q13219-82-unknown | EARGAT... | 82 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16379 | |||
| Q13219-467-unknown | NFDGGE... | 467 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26784 | |||
| Q13219-963-unknown | MNKING... | 963 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000441461 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...RRQQRE | 81 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16379 | |||
| ...NYERFN | 466 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC26784 | |||
| ...GYSHG | 1627 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| KLK4_HUMAN | 81 | QQRE.|.EARG | inferred from experiment | unknown | MEROPS | Nelson PS | Matsumura M et al.:Substrates of the prostate-spec... (S01.251) | 15389820, |
| PAPP1_HUMAN | 466 | ERFN.|.NFDG | inferred from experiment | unknown | MEROPS | Oxvig C | Boldt HB et al.:Mutational analysis of the prot... (M43.004) | 11513734, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| IBP4_HUMAN | 156 | GKMK.|.KVNG | inferred from experiment | unknown | MEROPS | Mohan S | Qin X et al.:Evidence that the interaction b... (M43.004) | 10898936, |
| IBP5_HUMAN | 163 | TQSK.|.KFVG | inferred from experiment | unknown | MEROPS | Oxvig C | Laursen LS et al.:Pregnancy-associated plasma pro... (M43.004) | 11522292, |
| IBP5_HUMAN | 164 | QSKF.|.FVGG | inferred from experiment | unknown | MEROPS | Oxvig C | Laursen LS et al.:Pregnancy-associated plasma pro... (M43.004) | 11522292, |
| PAPP1_HUMAN | 466 | ERFN.|.NFDG | inferred from experiment | unknown | MEROPS | Oxvig C | Boldt HB et al.:Mutational analysis of the prot... (M43.004) | 11513734, |