P22692: Insulin-like growth factor-binding protein 4

General Information

Protein names	- Insulin-like growth factor-binding protein 4 - IBP-4 - IGF-binding protein 4 - IGFBP-4
Gene names	IGFBP4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P22692

9 N-termini

9 C-termini

8 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MLPLCLVAAL LLAAGPGPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE PGCGCCATCA
        70         80         90        100        110        120
LGLGMPCGVY TPRCGSGLRC YPPRGVEKPL HTLMHGQGVC MELAEIEAIQ ESLQPSDKDE
       130        140        150        160        170        180
GDHPNNSFSP CSAHDRRCLQ KHFAKIRDRS TSGGKMKVNG APREDARPVP QGSCQSELHR
       190        200        210        220        230        240
ALERLAASQS RTHEDLYIIP IPNCDRNGNF HPKQCHPALD GQRGKCWCVD RKTGVKLPGG
       250
LEPKGELDCH QLADSFRE

Isoforms

- Isoform 2 of Insulin-like growth factor-binding protein 4

Sequence View

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Evidence Names:

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Protein Neighborhood

Domains & Features

9 N-termini - 9 C-termini - 8 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P22692-22-unknown	DEAIHC...	22	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P22692-22-unknown	DEAIHC...	22	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16457
P22692-24-unknown	AIHCPP...	24	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC741
P22692-101-unknown	MELAEI...	101	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437734
P22692-108-unknown	AIQESL...	108	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC742
P22692-144-unknown	AKIRDR...	144	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC743
P22692-156-unknown	MKVNGA...	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4589
P22692-157-unknown	KVNGAP...	157	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26781
P22692-160-unknown	GAPRED...	160	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC744
P22692-192-unknown	THEDLY...	192	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16458

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GPSLGD	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16457
...SLGDEA	23	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC741
...LAEIEA	107	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC742
...LQKHFA	143	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC743
...TSGGKM	155	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4589
...SGGKMK	156	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26781
...KMKVNG	159	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC744
...ASQSRT	191	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16458
...DSFRE	258	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK5_HUMAN	21	SLGD.\|.DEAI	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Human tissue kallikrein 5 is a ... (S01.017)	16517595,
CAN1_HUMAN	23	GDEA.\|.AIHC	inferred from experiment	unknown	MEROPS		Merops CAN1_HUMAN -> IBP4_HUMAN @23
CAN1_HUMAN	107	EIEA.\|.AIQE	inferred from experiment	unknown	MEROPS		Merops CAN1_HUMAN -> IBP4_HUMAN @107
CAN1_HUMAN	143	KHFA.\|.AKIR	inferred from experiment	unknown	MEROPS		Merops CAN1_HUMAN -> IBP4_HUMAN @143
CATD_HUMAN	155	GGKM.\|.MKVN	inferred from experiment	unknown	MEROPS	Braulke T	Claussen M et al.:Proteolysis of insulin-like gro... (A01.009)	9275067,
PAPP1_HUMAN	156	GKMK.\|.KVNG	inferred from experiment	unknown	MEROPS	Mohan S	Qin X et al.:Evidence that the interaction b... (M43.004)	10898936,
CAN1_HUMAN	159	KVNG.\|.GAPR	inferred from experiment	unknown	MEROPS		Merops CAN1_HUMAN -> IBP4_HUMAN @159
KLK5_HUMAN	191	QSRT.\|.THED	inferred from experiment	unknown	MEROPS	Diamandis EP	Michael IP et al.:Human tissue kallikrein 5 is a ... (S01.017)	16517595,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)