P48740: Mannan-binding lectin serine protease 1

General Information

Protein names	- Mannan-binding lectin serine protease 1 - 3.4.21.- - Complement factor MASP-3 - Complement-activating component of Ra-reactive factor - Mannose-binding lectin-associated serine protease 1 - MASP-1 - Mannose-binding protein-associated serine protease - Ra-reactive factor serine protease p100 - RaRF - Serine protease 5 - Mannan-binding lectin serine protease 1 heavy chain - Mannan-binding lectin serine protease 1 light chain
Gene names	MASP1
Organism	Homo sapiens
Protease Family	S01.132
Protease ID	S01.132
Chromosome location
UniProt ID	P48740

4 N-termini

2 C-termini

0 Cleavages

3 Substrates

Sequence

Isoforms

- Isoform 2 of Mannan-binding lectin serine protease 1 - Isoform 3 of Mannan-binding lectin serine protease 1 - Isoform 4 of Mannan-binding lectin serine protease 1

Sequence View

        10         20         30         40         50         60
MRWLLLYYAL CFSLSKASAH TVELNNMFGQ IQSPGYPDSY PSDSEVTWNI TVPDGFRIKL
        70         80         90        100        110        120
YFMHFNLESS YLCEYDYVKV ETEDQVLATF CGRETTDTEQ TPGQEVVLSP GSFMSITFRS
       130        140        150        160        170        180
DFSNEERFTG FDAHYMAVDV DECKEREDEE LSCDHYCHNY IGGYYCSCRF GYILHTDNRT
       190        200        210        220        230        240
CRVECSDNLF TQRTGVITSP DFPNPYPKSS ECLYTIELEE GFMVNLQFED IFDIEDHPEV
       250        260        270        280        290        300
PCPYDYIKIK VGPKVLGPFC GEKAPEPIST QSHSVLILFH SDNSGENRGW RLSYRAAGNE
       310        320        330        340        350        360
CPELQPPVHG KIEPSQAKYF FKDQVLVSCD TGYKVLKDNV EMDTFQIECL KDGTWSNKIP
       370        380        390        400        410        420
TCKIVDCRAP GELEHGLITF STRNNLTTYK SEIKYSCQEP YYKMLNNNTG IYTCSAQGVW
       430        440        450        460        470        480
MNKVLGRSLP TCLPVCGLPK FSRKLMARIF NGRPAQKGTT PWIAMLSHLN GQPFCGGSLL
       490        500        510        520        530        540
GSSWIVTAAH CLHQSLDPED PTLRDSDLLS PSDFKIILGK HWRLRSDENE QHLGVKHTTL
       550        560        570        580        590        600
HPQYDPNTFE NDVALVELLE SPVLNAFVMP ICLPEGPQQE GAMVIVSGWG KQFLQRFPET
       610        620        630        640        650        660
LMEIEIPIVD HSTCQKAYAP LKKKVTRDMI CAGEKEGGKD ACAGDSGGPM VTLNRERGQW
       670        680        690
YLVGTVSWGD DCGKKDRYGV YSYIHHNKDW IQRVTGVRN         10         20         30         40         50         60
MRWLLLYYAL CFSLSKASAH TVELNNMFGQ IQSPGYPDSY PSDSEVTWNI TVPDGFRIKL
        70         80         90        100        110        120
YFMHFNLESS YLCEYDYVKV ETEDQVLATF CGRETTDTEQ TPGQEVVLSP GSFMSITFRS
       130        140        150        160        170        180
DFSNEERFTG FDAHYMAVDV DECKEREDEE LSCDHYCHNY IGGYYCSCRF GYILHTDNRT
       190        200        210        220        230        240
CRVECSDNLF TQRTGVITSP DFPNPYPKSS ECLYTIELEE GFMVNLQFED IFDIEDHPEV
       250        260        270        280        290        300
PCPYDYIKIK VGPKVLGPFC GEKAPEPIST QSHSVLILFH SDNSGENRGW RLSYRAAGNE
       310        320        330        340        350        360
CPELQPPVHG KIEPSQAKYF FKDQVLVSCD TGYKVLKDNV EMDTFQIECL KDGTWSNKIP
       370        380        390        400        410        420
TCKIVDCRAP GELEHGLITF STRNNLTTYK SEIKYSCQEP YYKMLNNNTG IYTCSAQGVW
       430        440        450        460        470        480
MNKVLGRSLP TCLPVCGLPK FSRKLMARIF NGRPAQKGTT PWIAMLSHLN GQPFCGGSLL
       490        500        510        520        530        540
GSSWIVTAAH CLHQSLDPED PTLRDSDLLS PSDFKIILGK HWRLRSDENE QHLGVKHTTL
       550        560        570        580        590        600
HPQYDPNTFE NDVALVELLE SPVLNAFVMP ICLPEGPQQE GAMVIVSGWG KQFLQRFPET
       610        620        630        640        650        660
LMEIEIPIVD HSTCQKAYAP LKKKVTRDMI CAGEKEGGKD ACAGDSGGPM VTLNRERGQW
       670        680        690
YLVGTVSWGD DCGKKDRYGV YSYIHHNKDW IQRVTGVRN         10         20         30         40         50         60
MRWLLLYYAL CFSLSKASAH TVELNNMFGQ IQSPGYPDSY PSDSEVTWNI TVPDGFRIKL
        70         80         90        100        110        120
YFMHFNLESS YLCEYDYVKV ETEDQVLATF CGRETTDTEQ TPGQEVVLSP GSFMSITFRS
       130        140        150        160        170        180
DFSNEERFTG FDAHYMAVDV DECKEREDEE LSCDHYCHNY IGGYYCSCRF GYILHTDNRT
       190        200        210        220        230        240
CRVECSDNLF TQRTGVITSP DFPNPYPKSS ECLYTIELEE GFMVNLQFED IFDIEDHPEV
       250        260        270        280        290        300
PCPYDYIKIK VGPKVLGPFC GEKAPEPIST QSHSVLILFH SDNSGENRGW RLSYRAAGNE
       310        320        330        340        350        360
CPELQPPVHG KIEPSQAKYF FKDQVLVSCD TGYKVLKDNV EMDTFQIECL KDGTWSNKIP
       370        380        390        400        410        420
TCKIVDCRAP GELEHGLITF STRNNLTTYK SEIKYSCQEP YYKMLNNNTG IYTCSAQGVW
       430        440        450        460        470        480
MNKVLGRSLP TCLPVCGLPK FSRKLMARIF NGRPAQKGTT PWIAMLSHLN GQPFCGGSLL
       490        500        510        520        530        540
GSSWIVTAAH CLHQSLDPED PTLRDSDLLS PSDFKIILGK HWRLRSDENE QHLGVKHTTL
       550        560        570        580        590        600
HPQYDPNTFE NDVALVELLE SPVLNAFVMP ICLPEGPQQE GAMVIVSGWG KQFLQRFPET
       610        620        630        640        650        660
LMEIEIPIVD HSTCQKAYAP LKKKVTRDMI CAGEKEGGKD ACAGDSGGPM VTLNRERGQW
       670        680        690
YLVGTVSWGD DCGKKDRYGV YSYIHHNKDW IQRVTGVRN

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 0 Cleavages - 3 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P48740-1-unknown	MRWLLL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80452
P48740-1-unknown	MRWLLL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80453
P48740-20-unknown	HTVELN...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P48740-20-unknown	HTVELN...	20	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112472
P48740-20-unknown	HTVELN...	20	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112473
P48740-114-unknown	MSITFR...	114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt80454
P48740-114-unknown	MSITFR...	114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99816
P48740-114-unknown	MSITFR...	114	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt99817
P48740-449-unknown	IFNGRP...	449	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...KLMARI	448	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...TGVRN	699	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
IBP5_HUMAN	135	SPKI.\|.IFRP	inferred from experiment	unknown	MEROPS	Jiang W	Cortesio CL et al.:Mannan-binding lectin-associate... (S01.132)	16554018,
IBP5_HUMAN	140	RPKH.\|.HTRI	inferred from experiment	unknown	MEROPS	Jiang W	Cortesio CL et al.:Mannan-binding lectin-associate... (S01.132)	16554018,
IBP5_HUMAN	176	HPRI.\|.IISA	inferred from experiment	unknown	MEROPS	Jiang W	Cortesio CL et al.:Mannan-binding lectin-associate... (S01.132)	16554018,

TopFIND

P48740: Mannan-binding lectin serine protease 1

General Information

4

N-termini

2

C-termini

0

Cleavages

3

Substrates

Sequence

Isoforms

Filter Information:

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Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 0 Cleavages - 3 Substrates

N-termini

C-termini

Cleavages

Substrates