P37840: Alpha-synuclein

General Information

Protein names	- Alpha-synuclein - Non-A beta component of AD amyloid - Non-A4 component of amyloid precursor - NACP
Gene names	SNCA
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P37840

33 N-termini

29 C-termini

36 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2-4 of Alpha-synuclein - Isoform 2-5 of Alpha-synuclein

Sequence View

        10         20         30         40         50         60
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK
        70         80         90        100        110        120
EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP
       130        140
DNEAYEMPSE EGYQDYEPEA         10         20         30         40         50         60
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK
        70         80         90        100        110        120
EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP
       130        140
DNEAYEMPSE EGYQDYEPEA

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

33 N-termini - 29 C-termini - 36 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name
P37840-1-Acetylation	MDVFMK...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P37840-1-Acetylation	MDVFMK...	1	acetylation-		other		CNRS/ISV	Large_scale_NTA_Human
P37840-1-Acetylation	MDVFMK...	1	acetylation-		N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P37840-1-Acetylation	MDVFMK...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100056
P37840-1-Acetylation	MDVFMK...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt100057
P37840-1-unknown	MDVFMK...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91318
P37840-1-unknown	MDVFMK...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt91319
P37840-5-unknown	MKGLSK...	5		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26410
P37840-5-unknown	MKGLSK...	5		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194657
P37840-5-unknown	MKGLSK...	5		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194658
P37840-8-unknown	LSKAKE...	8		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21765
P37840-8-unknown	LSKAKE...	8		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26411
P37840-8-unknown	LSKAKE...	8		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194812
P37840-8-unknown	LSKAKE...	8		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194813
P37840-10-unknown	KAKEGV...	10		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC767
P37840-10-unknown	KAKEGV...	10		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194873
P37840-10-unknown	KAKEGV...	10		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt194874
P37840-19-unknown	AEKTKQ...	19		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21766
P37840-19-unknown	AEKTKQ...	19		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26412
P37840-19-unknown	AEKTKQ...	19		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136759
P37840-19-unknown	AEKTKQ...	19		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136761
P37840-22-unknown	TKQGVA...	22		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21769
P37840-22-unknown	TKQGVA...	22		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt136960
P37840-42-unknown	SKTKEG...	42		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21772
P37840-42-unknown	SKTKEG...	42		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138483
P37840-48-unknown	VVHGVA...	48		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21774
P37840-48-unknown	VVHGVA...	48		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt138946
P37840-55-unknown	VAEKTK...	55		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23901
P37840-55-unknown	VAEKTK...	55		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139523
P37840-55-unknown	VAEKTK...	55		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196217
P37840-58-unknown	KTKEQV...	58		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23903
P37840-58-unknown	KTKEQV...	58		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139731
P37840-58-unknown	KTKEQV...	58		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt196282
P37840-62-	QVTNVG...	62			N-TAILS		Overall Laboratory	Lange_Huesgen_et_al-RBC
P37840-62-unknown	QVTNVG...	62		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182708
P37840-62-unknown	QVTNVG...	62		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt182709
P37840-67-unknown	GGAVVT...	67		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26415
P37840-67-unknown	GGAVVT...	67		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139373
P37840-67-unknown	GGAVVT...	67		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140421
P37840-71-unknown	VTGVTA...	71		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21776
P37840-71-unknown	VTGVTA...	71		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26418
P37840-71-unknown	VTGVTA...	71		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139642
P37840-71-unknown	VTGVTA...	71		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140685
P37840-72-unknown	TGVTAV...	72		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21779
P37840-72-unknown	TGVTAV...	72		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26421
P37840-72-unknown	TGVTAV...	72		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139717
P37840-72-unknown	TGVTAV...	72		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140760
P37840-74-unknown	VTAVAQ...	74		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26424
P37840-74-unknown	VTAVAQ...	74		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139891
P37840-74-unknown	VTAVAQ...	74		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140879
P37840-75-unknown	TAVAQK...	75		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26427
P37840-75-unknown	TAVAQK...	75		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt139987
P37840-75-unknown	TAVAQK...	75		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140960
P37840-79-unknown	QKTVEG...	79		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21782
P37840-79-unknown	QKTVEG...	79		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26430
P37840-79-unknown	QKTVEG...	79		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23905
P37840-79-unknown	QKTVEG...	79		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140270
P37840-79-unknown	QKTVEG...	79		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141225
P37840-80-unknown	KTVEGA...	80		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23908
P37840-80-unknown	KTVEGA...	80		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140360
P37840-80-unknown	KTVEGA...	80		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141298
P37840-81-unknown	TVEGAG...	81		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23911
P37840-81-unknown	TVEGAG...	81		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140429
P37840-81-unknown	TVEGAG...	81		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141368
P37840-88-unknown	IAAATG...	88		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23914
P37840-88-unknown	IAAATG...	88		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt140889
P37840-91-unknown	ATGFVK...	91		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21785
P37840-91-unknown	ATGFVK...	91		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23917
P37840-91-unknown	ATGFVK...	91		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141089
P37840-92-unknown	TGFVKK...	92		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23920
P37840-92-unknown	TGFVKK...	92		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141182
P37840-94-unknown	FVKKDQ...	94		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23923
P37840-94-unknown	FVKKDQ...	94		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141300
P37840-95-unknown	VKKDQL...	95		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23925
P37840-95-unknown	VKKDQL...	95		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141371
P37840-98-unknown	DQLGKN...	98		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21788
P37840-98-unknown	DQLGKN...	98		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141503
P37840-99-unknown	QLGKNE...	99		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC26433
P37840-99-unknown	QLGKNE...	99		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141559
P37840-103-unknown	NEEGAP...	103		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC23927
P37840-103-unknown	NEEGAP...	103		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt141770
P37840-123-unknown	EAYEMP...	123		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC768
P37840-123-unknown	EAYEMP...	123		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142858
P37840-124-unknown	AYEMPS...	124		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4593
P37840-124-unknown	AYEMPS...	124		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt142973
P37840-134-unknown	QDYEPE...	134		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21790
P37840-134-unknown	QDYEPE...	134		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143457
P37840-134-unknown	QDYEPE...	134		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197230
P37840-135-unknown	DYEPEA...	135		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC21792
P37840-135-unknown	DYEPEA...	135		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt143506
P37840-135-unknown	DYEPEA...	135		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt197256

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VFMKGL	7	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21765
...VFMKGL	7	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26411
...MKGLSK	9	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC767
...GVVAAA	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21766
...GVVAAA	18	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26412
...AAAEKT	21	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21769
...AAAEKT	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119786
...AAAEKT	21	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt119788
...VLYVGS	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21772
...VLYVGS	41	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121527
...KTKEGV	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21774
...KTKEGV	47	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122013
...HGVATV	54	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23901
...HGVATV	54	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122613
...ATVAEK	57	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23903
...ATVAEK	57	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122830
...QVTNVG	66	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26415
...QVTNVG	66	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123544
...VGGAVV	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21776
...VGGAVV	70	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26418
...VGGAVV	70	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123820
...GGAVVT	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21779
...GGAVVT	71	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26421
...GGAVVT	71	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123895
...AVVTGV	73	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26424
...AVVTGV	73	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124020
...VVTGVT	74	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26427
...VVTGVT	74	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124107
...VTAVAQ	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21782
...VTAVAQ	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26430
...VTAVAQ	78	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23905
...VTAVAQ	78	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123391
...VTAVAQ	78	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124386
...TAVAQK	79	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23908
...TAVAQK	79	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123483
...TAVAQK	79	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124461
...AVAQKT	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23911
...AVAQKT	80	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123555
...AVAQKT	80	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124536
...EGAGSI	87	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23914
...EGAGSI	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124030
...EGAGSI	87	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124891
...GSIAAA	90	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21785
...GSIAAA	90	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23917
...GSIAAA	90	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124242
...GSIAAA	90	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125037
...SIAAAT	91	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23920
...SIAAAT	91	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124340
...SIAAAT	91	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt125122
...AAATGF	93	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23923
...AAATGF	93	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124463
...AAATGF	93	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154105
...AATGFV	94	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23925
...AATGFV	94	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124539
...AATGFV	94	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154117
...GFVKKD	97	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21788
...GFVKKD	97	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124680
...GFVKKD	97	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154153
...FVKKDQ	98	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26433
...FVKKDQ	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124736
...FVKKDQ	98	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154173
...DQLGKN	102	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23927
...DQLGKN	102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124950
...DQLGKN	102	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154244
...VDPDNE	122	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC768
...VDPDNE	122	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126067
...DPDNEA	123	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4593
...DPDNEA	123	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126181
...SEEGYQ	133	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21790
...SEEGYQ	133	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126690
...EEGYQD	134	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21792
...EEGYQD	134	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt126746
...YEPEA	140	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...YEPEA	140	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt86937

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP9_HUMAN	4	DVFM.\|.MKGL	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP1_HUMAN	7	MKGL.\|.LSKA	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP9_HUMAN	7	MKGL.\|.LSKA	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
CAN1_HUMAN	9	GLSK.\|.KAKE	inferred from experiment	unknown	MEROPS	Rohn TT	Dufty BM et al.:Calpain-cleavage of alpha-synuc... (C02.001)	17456777,
MMP1_HUMAN	18	VAAA.\|.AEKT	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP9_HUMAN	18	VAAA.\|.AEKT	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP1_HUMAN	21	AEKT.\|.TKQG	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP1_HUMAN	41	YVGS.\|.SKTK	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP1_HUMAN	47	KEGV.\|.VVHG	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP3_HUMAN	54	VATV.\|.VAEK	inferred from experiment	unknown	MEROPS	Chung KC	Sung JY et al.:Proteolytic cleavage of extrace... (M10.005)	15863497,
MMP3_HUMAN	57	VAEK.\|.KTKE	inferred from experiment	unknown	MEROPS	Chung KC	Sung JY et al.:Proteolytic cleavage of extrace... (M10.005)	15863497,
MMP9_HUMAN	66	TNVG.\|.GGAV	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP1_HUMAN	70	GAVV.\|.VTGV	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP9_HUMAN	70	GAVV.\|.VTGV	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP1_HUMAN	71	AVVT.\|.TGVT	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP9_HUMAN	71	AVVT.\|.TGVT	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP9_HUMAN	73	VTGV.\|.VTAV	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP9_HUMAN	74	TGVT.\|.TAVA	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP1_HUMAN	78	AVAQ.\|.QKTV	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP9_HUMAN	78	AVAQ.\|.QKTV	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP3_HUMAN	78	AVAQ.\|.QKTV	inferred from experiment	unknown	MEROPS	Chung KC	Sung JY et al.:Proteolytic cleavage of extrace... (M10.005)	15863497,
MMP3_HUMAN	79	VAQK.\|.KTVE	inferred from experiment	unknown	MEROPS	Chung KC	Sung JY et al.:Proteolytic cleavage of extrace... (M10.005)	15863497,
MMP3_HUMAN	80	AQKT.\|.TVEG	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP3_HUMAN	87	AGSI.\|.IAAA	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP1_HUMAN	90	IAAA.\|.ATGF	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP3_HUMAN	90	IAAA.\|.ATGF	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP3_HUMAN	91	AAAT.\|.TGFV	inferred from experiment	unknown	MEROPS	Chung KC	Sung JY et al.:Proteolytic cleavage of extrace... (M10.005)	15863497,
MMP3_HUMAN	93	ATGF.\|.FVKK	inferred from experiment	unknown	MEROPS	Chung KC	Sung JY et al.:Proteolytic cleavage of extrace... (M10.005)	15863497,
MMP3_HUMAN	94	TGFV.\|.VKKD	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP1_HUMAN	97	VKKD.\|.DQLG	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP9_HUMAN	98	KKDQ.\|.QLGK	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP3_HUMAN	102	LGKN.\|.NEEG	inferred from experiment	unknown	MEROPS	Chung KC	Sung JY et al.:Proteolytic cleavage of extrace... (M10.005)	15863497,
CAN1_HUMAN	122	PDNE.\|.EAYE	inferred from experiment	unknown	MEROPS	Rohn TT	Dufty BM et al.:Calpain-cleavage of alpha-synuc... (C02.001)	17456777,
CATD_HUMAN	123	DNEA.\|.AYEM	inferred from experiment	unknown	MEROPS	Yen SH	Sevlever D et al.:Cathepsin D is the main lysosom... (A01.009)	18702517,
MMP1_HUMAN	133	EGYQ.\|.QDYE	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,
MMP1_HUMAN	134	GYQD.\|.DYEP	inferred from experiment	unknown	MEROPS	Lorenzl S	Levin J et al.:Increased alpha-synuclein aggre... (M10.001)	19022250,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)