Q16849: Receptor-type tyrosine-protein phosphatase-like N
Protein names | - Receptor-type tyrosine-protein phosphatase-like N - R-PTP-N - Islet cell antigen 512 {ECO:0000303|PubMed:8144912} - ICA 512 {ECO:0000303|PubMed:8641276} - Islet cell autoantigen 3 - PTP IA-2 - ICA512-N-terminal fragment - ICA512-NTF - ICA512-transmembrane fragment - ICA512-TMF - ICA512-cleaved cytosolic fragment - ICA512-CCF |
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Gene names | PTPRN |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q16849 |
5
N-termini
3
C-termini
2
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MRRPRRPGGL GGSGGLRLLL CLLLLSSRPG GCSAVSAHGC LFDRRLCSHL EVCIQDGLFG
70 80 90 100 110 120
QCQVGVGQAR PLLQVTSPVL QRLQGVLRQL MSQGLSWHDD LTQYVISQEM ERIPRLRPPE
130 140 150 160 170 180
PRPRDRSGLA PKRPGPAGEL LLQDIPTGSA PAAQHRLPQP PVGKGGAGAS SSLSPLQAEL
190 200 210 220 230 240
LPPLLEHLLL PPQPPHPSLS YEPALLQPYL FHQFGSRDGS RVSEGSPGMV SVGPLPKAEA
250 260 270 280 290 300
PALFSRTASK GIFGDHPGHS YGDLPGPSPA QLFQDSGLLY LAQELPAPSR ARVPRLPEQG
310 320 330 340 350 360
SSSRAEDSPE GYEKEGLGDR GEKPASPAVQ PDAALQRLAA VLAGYGVELR QLTPEQLSTL
370 380 390 400 410 420
LTLLQLLPKG AGRNPGGVVN VGADIKKTME GPVEGRDTAE LPARTSPMPG HPTASPTSSE
430 440 450 460 470 480
VQQVPSPVSS EPPKAARPPV TPVLLEKKSP LGQSQPTVAG QPSARPAAEE YGYIVTDQKP
490 500 510 520 530 540
LSLAAGVKLL EILAEHVHMS SGSFINISVV GPALTFRIRH NEQNLSLADV TQQAGLVKSE
550 560 570 580 590 600
LEAQTGLQIL QTGVGQREEA AAVLPQTAHS TSPMRSVLLT LVALAGVAGL LVALAVALCV
610 620 630 640 650 660
RQHARQQDKE RLAALGPEGA HGDTTFEYQD LCRQHMATKS LFNRAEGPPE PSRVSSVSSQ
670 680 690 700 710 720
FSDAAQASPS SHSSTPSWCE EPAQANMDIS TGHMILAYME DHLRNRDRLA KEWQALCAYQ
730 740 750 760 770 780
AEPNTCATAQ GEGNIKKNRH PDFLPYDHAR IKLKVESSPS RSDYINASPI IEHDPRMPAY
790 800 810 820 830 840
IATQGPLSHT IADFWQMVWE SGCTVIVMLT PLVEDGVKQC DRYWPDEGAS LYHVYEVNLV
850 860 870 880 890 900
SEHIWCEDFL VRSFYLKNVQ TQETRTLTQF HFLSWPAEGT PASTRPLLDF RRKVNKCYRG
910 920 930 940 950 960
RSCPIIVHCS DGAGRTGTYI LIDMVLNRMA KGVKEIDIAA TLEHVRDQRP GLVRSKDQFE
970
FALTAVAEEV NAILKALPQ
Isoforms
- Isoform 2 of Receptor-type tyrosine-protein phosphatase-like N - Isoform 3 of Receptor-type tyrosine-protein phosphatase-like NSequence View
10 20 30 40 50 60
MRRPRRPGGL GGSGGLRLLL CLLLLSSRPG GCSAVSAHGC LFDRRLCSHL EVCIQDGLFG
70 80 90 100 110 120
QCQVGVGQAR PLLQVTSPVL QRLQGVLRQL MSQGLSWHDD LTQYVISQEM ERIPRLRPPE
130 140 150 160 170 180
PRPRDRSGLA PKRPGPAGEL LLQDIPTGSA PAAQHRLPQP PVGKGGAGAS SSLSPLQAEL
190 200 210 220 230 240
LPPLLEHLLL PPQPPHPSLS YEPALLQPYL FHQFGSRDGS RVSEGSPGMV SVGPLPKAEA
250 260 270 280 290 300
PALFSRTASK GIFGDHPGHS YGDLPGPSPA QLFQDSGLLY LAQELPAPSR ARVPRLPEQG
310 320 330 340 350 360
SSSRAEDSPE GYEKEGLGDR GEKPASPAVQ PDAALQRLAA VLAGYGVELR QLTPEQLSTL
370 380 390 400 410 420
LTLLQLLPKG AGRNPGGVVN VGADIKKTME GPVEGRDTAE LPARTSPMPG HPTASPTSSE
430 440 450 460 470 480
VQQVPSPVSS EPPKAARPPV TPVLLEKKSP LGQSQPTVAG QPSARPAAEE YGYIVTDQKP
490 500 510 520 530 540
LSLAAGVKLL EILAEHVHMS SGSFINISVV GPALTFRIRH NEQNLSLADV TQQAGLVKSE
550 560 570 580 590 600
LEAQTGLQIL QTGVGQREEA AAVLPQTAHS TSPMRSVLLT LVALAGVAGL LVALAVALCV
610 620 630 640 650 660
RQHARQQDKE RLAALGPEGA HGDTTFEYQD LCRQHMATKS LFNRAEGPPE PSRVSSVSSQ
670 680 690 700 710 720
FSDAAQASPS SHSSTPSWCE EPAQANMDIS TGHMILAYME DHLRNRDRLA KEWQALCAYQ
730 740 750 760 770 780
AEPNTCATAQ GEGNIKKNRH PDFLPYDHAR IKLKVESSPS RSDYINASPI IEHDPRMPAY
790 800 810 820 830 840
IATQGPLSHT IADFWQMVWE SGCTVIVMLT PLVEDGVKQC DRYWPDEGAS LYHVYEVNLV
850 860 870 880 890 900
SEHIWCEDFL VRSFYLKNVQ TQETRTLTQF HFLSWPAEGT PASTRPLLDF RRKVNKCYRG
910 920 930 940 950 960
RSCPIIVHCS DGAGRTGTYI LIDMVLNRMA KGVKEIDIAA TLEHVRDQRP GLVRSKDQFE
970
FALTAVAEEV NAILKALPQ
10 20 30 40 50 60
MRRPRRPGGL GGSGGLRLLL CLLLLSSRPG GCSAVSAHGC LFDRRLCSHL EVCIQDGLFG
70 80 90 100 110 120
QCQVGVGQAR PLLQVTSPVL QRLQGVLRQL MSQGLSWHDD LTQYVISQEM ERIPRLRPPE
130 140 150 160 170 180
PRPRDRSGLA PKRPGPAGEL LLQDIPTGSA PAAQHRLPQP PVGKGGAGAS SSLSPLQAEL
190 200 210 220 230 240
LPPLLEHLLL PPQPPHPSLS YEPALLQPYL FHQFGSRDGS RVSEGSPGMV SVGPLPKAEA
250 260 270 280 290 300
PALFSRTASK GIFGDHPGHS YGDLPGPSPA QLFQDSGLLY LAQELPAPSR ARVPRLPEQG
310 320 330 340 350 360
SSSRAEDSPE GYEKEGLGDR GEKPASPAVQ PDAALQRLAA VLAGYGVELR QLTPEQLSTL
370 380 390 400 410 420
LTLLQLLPKG AGRNPGGVVN VGADIKKTME GPVEGRDTAE LPARTSPMPG HPTASPTSSE
430 440 450 460 470 480
VQQVPSPVSS EPPKAARPPV TPVLLEKKSP LGQSQPTVAG QPSARPAAEE YGYIVTDQKP
490 500 510 520 530 540
LSLAAGVKLL EILAEHVHMS SGSFINISVV GPALTFRIRH NEQNLSLADV TQQAGLVKSE
550 560 570 580 590 600
LEAQTGLQIL QTGVGQREEA AAVLPQTAHS TSPMRSVLLT LVALAGVAGL LVALAVALCV
610 620 630 640 650 660
RQHARQQDKE RLAALGPEGA HGDTTFEYQD LCRQHMATKS LFNRAEGPPE PSRVSSVSSQ
670 680 690 700 710 720
FSDAAQASPS SHSSTPSWCE EPAQANMDIS TGHMILAYME DHLRNRDRLA KEWQALCAYQ
730 740 750 760 770 780
AEPNTCATAQ GEGNIKKNRH PDFLPYDHAR IKLKVESSPS RSDYINASPI IEHDPRMPAY
790 800 810 820 830 840
IATQGPLSHT IADFWQMVWE SGCTVIVMLT PLVEDGVKQC DRYWPDEGAS LYHVYEVNLV
850 860 870 880 890 900
SEHIWCEDFL VRSFYLKNVQ TQETRTLTQF HFLSWPAEGT PASTRPLLDF RRKVNKCYRG
910 920 930 940 950 960
RSCPIIVHCS DGAGRTGTYI LIDMVLNRMA KGVKEIDIAA TLEHVRDQRP GLVRSKDQFE
970
FALTAVAEEV NAILKALPQ
Protein Neighborhood
Domains & Features
5 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q16849-1-unknown | MRRPRR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt86589 | |||
Q16849-35-unknown | VSAHGC... | 35 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q16849-35-unknown | VSAHGC... | 35 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
Q16849-35-unknown | VSAHGC... | 35 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt115236 | |||
Q16849-91-unknown | MSQGLS... | 91 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt86590 | |||
Q16849-91-unknown | MSQGLS... | 91 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt99337 | |||
Q16849-609-unknown | KERLAA... | 609 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC843 | |||
Q16849-609-unknown | KERLAA... | 609 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt153618 | |||
Q16849-609-unknown | KERLAA... | 609 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154324 | |||
Q16849-660-unknown | QFSDAA... | 660 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC846 | |||
Q16849-660-unknown | QFSDAA... | 660 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt154215 | |||
Q16849-660-unknown | QFSDAA... | 660 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt155067 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...ARQQDK | 608 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC843 | |||
...ARQQDK | 608 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137041 | |||
...ARQQDK | 608 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137745 | |||
...SSVSSQ | 659 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC846 | |||
...SSVSSQ | 659 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt137636 | |||
...SSVSSQ | 659 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt138494 | |||
...KALPQ | 979 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
...KALPQ | 979 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt82208 | |||
...KALPQ | 979 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt82207 |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
CAN1_HUMAN | 608 | QQDK.|.KERL | inferred from experiment | unknown | MEROPS | Solimena M | Ort T et al.:Dephosphorylation of beta2-synt... (C02.001) | 11483505, |
CAN1_HUMAN | 659 | VSSQ.|.QFSD | inferred from experiment | unknown | MEROPS | Solimena M | Ort T et al.:Dephosphorylation of beta2-synt... (C02.001) | 11483505, |
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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