Q07812: Apoptosis regulator BAX

General Information

Protein names	- Apoptosis regulator BAX - Bcl-2-like protein 4 - Bcl2-L-4
Gene names	BAX
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q07812

6 N-termini

3 C-termini

2 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform Beta of Apoptosis regulator BAX - Isoform Gamma of Apoptosis regulator BAX - Isoform Delta of Apoptosis regulator BAX - Isoform Epsilon of Apoptosis regulator BAX - Isoform Zeta of Apoptosis regulator BAX - Isoform Psi of Apoptosis regulator BAX - Isoform Sigma of Apoptosis regulator BAX

Sequence View

        10         20         30         40         50         60
MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS
        70         80         90        100        110        120
ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF SDGNFNWGRV VALFYFASKL
       130        140        150        160        170        180
VLKALCTKVP ELIRTIMGWT LDFLRERLLG WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV
       190
LTASLTIWKK MG         10         20         30         40         50         60
MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS
        70         80         90        100        110        120
ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF SDGNFNWGRV VALFYFASKL
       130        140        150        160        170        180
VLKALCTKVP ELIRTIMGWT LDFLRERLLG WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV
       190
LTASLTIWKK MG         10         20         30         40         50         60
MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS
        70         80         90        100        110        120
ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF SDGNFNWGRV VALFYFASKL
       130        140        150        160        170        180
VLKALCTKVP ELIRTIMGWT LDFLRERLLG WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV
       190
LTASLTIWKK MG         10         20         30         40         50         60
MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS
        70         80         90        100        110        120
ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF SDGNFNWGRV VALFYFASKL
       130        140        150        160        170        180
VLKALCTKVP ELIRTIMGWT LDFLRERLLG WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV
       190
LTASLTIWKK MG         10         20         30         40         50         60
MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS
        70         80         90        100        110        120
ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF SDGNFNWGRV VALFYFASKL
       130        140        150        160        170        180
VLKALCTKVP ELIRTIMGWT LDFLRERLLG WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV
       190
LTASLTIWKK MG         10         20         30         40         50         60
MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS
        70         80         90        100        110        120
ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF SDGNFNWGRV VALFYFASKL
       130        140        150        160        170        180
VLKALCTKVP ELIRTIMGWT LDFLRERLLG WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV
       190
LTASLTIWKK MG         10         20         30         40         50         60
MDGSGEQPRG GGPTSSEQIM KTGALLLQGF IQDRAGRMGG EAPELALDPV PQDASTKKLS
        70         80         90        100        110        120
ECLKRIGDEL DSNMELQRMI AAVDTDSPRE VFFRVAADMF SDGNFNWGRV VALFYFASKL
       130        140        150        160        170        180
VLKALCTKVP ELIRTIMGWT LDFLRERLLG WIQDQGGWDG LLSYFGTPTW QTVTIFVAGV
       190
LTASLTIWKK MG

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

6 N-termini - 3 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q07812-1-unknown	MDGSGE...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68228
Q07812-1-unknown	MDGSGE...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68230
Q07812-1-unknown	MDGSGE...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68231
Q07812-1-unknown	MDGSGE...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68234
Q07812-1-Acetylation	MDGSGE...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q07812-1-Acetylation	MDGSGE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt107118
Q07812-1-Acetylation	MDGSGE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt107119
Q07812-1-Acetylation	MDGSGE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt107120
Q07812-1-Acetylation	MDGSGE...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt107121
Q07812-20-unknown	MKTGAL...	20		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68233
Q07812-20-unknown	MKTGAL...	20		inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q07812-20-unknown	MKTGAL...	20		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103641
Q07812-20-unknown	MKTGAL...	20		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103642
Q07812-20-unknown	MKTGAL...	20		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103643
Q07812-29-unknown	GFIQDR...	29		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC816
Q07812-29-unknown	GFIQDR...	29		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137450
Q07812-29-unknown	GFIQDR...	29		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137451
Q07812-29-unknown	GFIQDR...	29		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137452
Q07812-29-unknown	GFIQDR...	29		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt195582
Q07812-34-unknown	RAGRMG...	34		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2086
Q07812-34-unknown	RAGRMG...	34		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt136534
Q07812-34-unknown	RAGRMG...	34		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137854
Q07812-34-unknown	RAGRMG...	34		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137855
Q07812-34-unknown	RAGRMG...	34		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137856
Q07812-79-unknown	MIAAVD...	79		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt68232
Q07812-79-unknown	MIAAVD...	79		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103595
Q07812-79-unknown	MIAAVD...	79		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103593
Q07812-79-unknown	MIAAVD...	79		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103592
Q07812-79-unknown	MIAAVD...	79		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103594
Q07812-79-unknown	MIAAVD...	79		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt103596

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ALLLQG	28	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC816
...ALLLQG	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120412
...ALLLQG	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120413
...ALLLQG	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120414
...ALLLQG	28	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153743
...GFIQDR	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2086
...GFIQDR	33	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120858
...GFIQDR	33	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120859
...GFIQDR	33	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120860
...WKKMG	192	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...WKKMG	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63850
...WKKMG	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63848
...WKKMG	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63851
...WKKMG	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63852

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CAN1_HUMAN	28	LLQG.\|.GFIQ	inferred from experiment	unknown	MEROPS		Merops CAN1_HUMAN -> BAX_HUMAN @28
CASP3_HUMAN	33	IQDR.\|.RAGR	inferred from experiment	unknown	MEROPS	Mizuguchi J	Yanase N et al.:Cytochrome c release, mitochond... (C14.003)	11152579,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)