P04070: Vitamin K-dependent protein C

General Information

Protein names	- Vitamin K-dependent protein C - 3.4.21.69 - Anticoagulant protein C - Autoprothrombin IIA - Blood coagulation factor XIV - Vitamin K-dependent protein C light chain - Vitamin K-dependent protein C heavy chain - Activation peptide
Gene names	PROC
Organism	Homo sapiens
Protease Family	S01.218
Protease ID	S01.218
Chromosome location
UniProt ID	P04070

5 N-termini

8 C-termini

9 Cleavages

10 Substrates

Sequence

        10         20         30         40         50         60
MWQLTSLLLF VATWGISGTP APLDSVFSSS ERAHQVLRIR KRANSFLEEL RHSSLERECI
        70         80         90        100        110        120
EEICDFEEAK EIFQNVDDTL AFWSKHVDGD QCLVLPLEHP CASLCCGHGT CIDGIGSFSC
       130        140        150        160        170        180
DCRSGWEGRF CQREVSFLNC SLDNGGCTHY CLEEVGWRRC SCAPGYKLGD DLLQCHPAVK
       190        200        210        220        230        240
FPCGRPWKRM EKKRSHLKRD TEDQEDQVDP RLIDGKMTRR GDSPWQVVLL DSKKKLACGA
       250        260        270        280        290        300
VLIHPSWVLT AAHCMDESKK LLVRLGEYDL RRWEKWELDL DIKEVFVHPN YSKSTTDNDI
       310        320        330        340        350        360
ALLHLAQPAT LSQTIVPICL PDSGLAEREL NQAGQETLVT GWGYHSSREK EAKRNRTFVL
       370        380        390        400        410        420
NFIKIPVVPH NECSEVMSNM VSENMLCAGI LGDRQDACEG DSGGPMVASF HGTWFLVGLV
       430        440        450        460
SWGEGCGLLH NYGVYTKVSR YLDWIHGHIR DKEAPQKSWA P

Isoforms

- Isoform 2 of Vitamin K-dependent protein C

Sequence View

        10         20         30         40         50         60
MWQLTSLLLF VATWGISGTP APLDSVFSSS ERAHQVLRIR KRANSFLEEL RHSSLERECI
        70         80         90        100        110        120
EEICDFEEAK EIFQNVDDTL AFWSKHVDGD QCLVLPLEHP CASLCCGHGT CIDGIGSFSC
       130        140        150        160        170        180
DCRSGWEGRF CQREVSFLNC SLDNGGCTHY CLEEVGWRRC SCAPGYKLGD DLLQCHPAVK
       190        200        210        220        230        240
FPCGRPWKRM EKKRSHLKRD TEDQEDQVDP RLIDGKMTRR GDSPWQVVLL DSKKKLACGA
       250        260        270        280        290        300
VLIHPSWVLT AAHCMDESKK LLVRLGEYDL RRWEKWELDL DIKEVFVHPN YSKSTTDNDI
       310        320        330        340        350        360
ALLHLAQPAT LSQTIVPICL PDSGLAEREL NQAGQETLVT GWGYHSSREK EAKRNRTFVL
       370        380        390        400        410        420
NFIKIPVVPH NECSEVMSNM VSENMLCAGI LGDRQDACEG DSGGPMVASF HGTWFLVGLV
       430        440        450        460
SWGEGCGLLH NYGVYTKVSR YLDWIHGHIR DKEAPQKSWA P

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P04070-1-unknown	MWQLTS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt131430
P04070-19-unknown	TPAPLD...	19	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P04070-19-unknown	TPAPLD...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112068
P04070-43-unknown	ANSFLE...	43	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P04070-43-unknown	ANSFLE...	43	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9701
P04070-43-unknown	ANSFLE...	43	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt115479
P04070-200-unknown	DTEDQE...	200	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P04070-200-unknown	DTEDQE...	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26976
P04070-200-unknown	DTEDQE...	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27272
P04070-200-unknown	DTEDQE...	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26565
P04070-200-unknown	DTEDQE...	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26831
P04070-200-unknown	DTEDQE...	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9703
P04070-200-unknown	DTEDQE...	200	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27123
P04070-200-unknown	DTEDQE...	200	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt116015
P04070-212-unknown	LIDGKM...	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31745
P04070-212-unknown	LIDGKM...	212	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16281
P04070-212-unknown	LIDGKM...	212	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149034

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RIRKRA	42	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9701
...RIRKRA	42	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt123380
...IDGIGS	116	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000406295
...IDGIGS	116	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt111768
...CRSGWE	126	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000412697
...CRSGWE	126	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt111764
...MEKKRS	194	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000411241
...MEKKRS	194	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt111766
...KRSHLK	197	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KRSHLK	197	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91915
...SHLKRD	199	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26976
...SHLKRD	199	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27272
...SHLKRD	199	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26565
...SHLKRD	199	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC26831
...SHLKRD	199	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9703
...SHLKRD	199	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27123
...SHLKRD	199	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132016
...QVDPRL	211	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31745
...QVDPRL	211	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16281
...QVDPRL	211	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132417
...KSWAP	461	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...KSWAP	461	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt81849

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
FURIN_HUMAN	42	RKRA.\|.ANSF	inferred from experiment	unknown	MEROPS	Lubon H	Drews R et al.:Proteolytic maturation of prote... (S08.071)	7479820,
PCSK5_HUMAN	199	LKRD.\|.DTED	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK7_HUMAN	199	LKRD.\|.DTED	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
NEC2_HUMAN	199	LKRD.\|.DTED	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
PCSK4_HUMAN	199	LKRD.\|.DTED	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
FURIN_HUMAN	199	LKRD.\|.DTED	inferred from experiment	unknown	MEROPS	Lubon H	Drews R et al.:Proteolytic maturation of prote... (S08.071)	7479820,
PCSK6_HUMAN	199	LKRD.\|.DTED	inferred from experiment	unknown	MEROPS	Strongin AY	Remacle AG et al.:Substrate cleavage analysis of ... (S08.071)	18505722,
THRB_HUMAN	211	DPRL.\|.LIDG	inferred from experiment	unknown	MEROPS	Bouma BN	Hackeng TM et al.:Protein C activation on endothe... (S01.217)	8912673,
KLK4_HUMAN	211	DPRL.\|.LIDG	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PAR1_HUMAN	41	DPRS.\|.SFLL	inferred from experiment	unknown	MEROPS	Stone SR	Parry MA et al.:Cleavage of the thrombin recept... (S01.216)	8947506,
FA5_HUMAN	334	KTRN.\|.NLKK	inferred from experiment	unknown	MEROPS		Merops PROC_HUMAN -> FA5_HUMAN @334
PAI1-Isoform2_HUMAN	354	SARM.\|.MAPE	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC27763
FA8_HUMAN	355	QLRM.\|.MKNN	inferred from experiment	unknown	MEROPS	Fay PJ	Nogami K et al.:Mechanisms of factor Xa-catalyz... (S01.216)	12606556,
PAI1_HUMAN	369	SARM.\|.MAPE	inferred from experiment	unknown	MEROPS	Gruber A	Komissarov AA et al.:Redirection of the reaction bet... (S01.218)	18045665,
FA5_HUMAN	534	DRRG.\|.GIQR	inferred from experiment	unknown	MEROPS		Merops PROC_HUMAN -> FA5_HUMAN @534
FA8_HUMAN	581	DQRG.\|.GNQI	inferred from experiment	unknown	MEROPS	Walker FJ	Fay PJ et al.:Activated protein C-catalyzed i... (S01.218)	1939075,
FA5_HUMAN	707	ATRK.\|.KMHD	inferred from experiment	unknown	MEROPS		Merops PROC_HUMAN -> FA5_HUMAN @707
FA8_HUMAN	759	EPRS.\|.SFSQ	inferred from experiment	unknown	MEROPS	Walker FJ	Fay PJ et al.:Activated protein C-catalyzed i... (S01.218)	1939075,
FA5_HUMAN	1022	LKKS.\|.SQFL	inferred from experiment	unknown	MEROPS	Mann KG	Kalafatis M et al.:The mechanism of inactivation o... (S01.218)	7989361,

TopFIND

P04070: Vitamin K-dependent protein C

General Information

5

N-termini

8

C-termini

9

Cleavages

10

Substrates

Sequence

Isoforms

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Protein Neighborhood

Domains & Features

5 N-termini - 8 C-termini - 9 Cleavages - 10 Substrates

N-termini

C-termini

Cleavages

Substrates