P05121: Plasminogen activator inhibitor 1

General Information

Protein names	- Plasminogen activator inhibitor 1 - PAI - PAI-1 - Endothelial plasminogen activator inhibitor - Serpin E1
Gene names	SERPINE1
Organism	Homo sapiens
Protease Family
Protease ID	I04.020
Chromosome location
UniProt ID	P05121

6 N-termini

5 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQMSPALTCL VLGLALVFGE GSAVHHPPSY VAHLASDFGV RVFQQVAQAS KDRNVVFSPY
        70         80         90        100        110        120
GVASVLAMLQ LTTGGETQQQ IQAAMGFKID DKGMAPALRH LYKELMGPWN KDEISTTDAI
       130        140        150        160        170        180
FVQRDLKLVQ GFMPHFFRLF RSTVKQVDFS EVERARFIIN DWVKTHTKGM ISNLLGKGAV
       190        200        210        220        230        240
DQLTRLVLVN ALYFNGQWKT PFPDSSTHRR LFHKSDGSTV SVPMMAQTNK FNYTEFTTPD
       250        260        270        280        290        300
GHYYDILELP YHGDTLSMFI AAPYEKEVPL SALTNILSAQ LISHWKGNMT RLPRLLVLPK
       310        320        330        340        350        360
FSLETEVDLR KPLENLGMTD MFRQFQADFT SLSDQEPLHV AQALQKVKIE VNESGTVASS
       370        380        390        400
STAVIVSARM APEEIIMDRP FLFVVRHNPT GTVLFMGQVM EP

Isoforms

- Isoform 2 of Plasminogen activator inhibitor 1

Sequence View

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Protein Neighborhood

Domains & Features

6 N-termini - 5 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P05121-1-unknown	MQMSPA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt84162
P05121-24-unknown	VHHPPS...	24	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P05121-360-unknown	SSTAVI...	360	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23799
P05121-360-unknown	SSTAVI...	360	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150860
P05121-361-unknown	STAVIV...	361	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23801
P05121-361-unknown	STAVIV...	361	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150879
P05121-365-unknown	IVSARM...	365	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23803
P05121-365-unknown	IVSARM...	365	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150949
P05121-370-unknown	MAPEEI...	370	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27763
P05121-370-unknown	MAPEEI...	370	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31859
P05121-370-unknown	MAPEEI...	370	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31869
P05121-370-unknown	MAPEEI...	370	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16075
P05121-370-unknown	MAPEEI...	370	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151055

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GTVASS	359	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23799
...GTVASS	359	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134261
...TVASSS	360	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23801
...TVASSS	360	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134281
...SSTAVI	364	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23803
...SSTAVI	364	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134351
...IVSARM	369	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27763
...IVSARM	369	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31859
...IVSARM	369	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31869
...IVSARM	369	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16075
...IVSARM	369	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134458
...QVMEP	402	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...QVMEP	402	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79780

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP3_HUMAN	359	VASS.\|.SSTA	inferred from experiment	unknown	MEROPS		Merops MMP3_HUMAN -> PAI1_HUMAN @359
MMP3_HUMAN	360	ASSS.\|.STAV	inferred from experiment	unknown	MEROPS	Declerck PJ	Lijnen HR et al.:Inactivation of plasminogen act... (M10.005)	10967118,
MMP3_HUMAN	364	TAVI.\|.IVSA	inferred from experiment	unknown	MEROPS	Declerck PJ	Lijnen HR et al.:Inactivation of plasminogen act... (M10.005)	10967118,
PROC_HUMAN	369	SARM.\|.MAPE	inferred from experiment	unknown	MEROPS	Gruber A	Komissarov AA et al.:Redirection of the reaction bet... (S01.218)	18045665,
TMPS7_HUMAN	369	SARM.\|.MAPE	inferred from experiment	unknown	MEROPS	Bugge TH	Szabo R et al.:Matriptase-3 is a novel phyloge... (S01.072)	15853774,
TPA_HUMAN	369	SARM.\|.MAPE	inferred from experiment	unknown	MEROPS	Collen D	Declerck PJ et al.:Identification of a conformatio... (S01.232)	1601844,
KLK2_HUMAN	369	SARM.\|.MAPE	inferred from experiment	unknown	MEROPS	Saedi MS	Mikolajczyk SD et al.:Prostatic human kallikrein 2 in... (S01.161)	10209959,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)