TopFIND 4.0

Q7RTY8: Transmembrane protease serine 7

General Information

Protein names
- Transmembrane protease serine 7
- 3.4.21.-
- Matriptase-3
Gene names TMPRSS7
Organism Homo sapiens
Protease Family S01.072
Protease ID S01.072
Chromosome location
UniProt ID Q7RTY8

3

N-termini

1

C-termini

0

Cleavages

7

Substrates

Sequence

        10         20         30         40         50         60 
MDKENSDVSA APADLKISNI SVQVVSAQKK LPVRRPPLPG RRLPLPGRRP PQRPIGKAKP 
        70         80         90        100        110        120 
KKQSKKKVPF WNVQNKIILF TVFLFILAVI AWTLLWLYIS KTESKDAFYF AGMFRITNIE 
       130        140        150        160        170        180 
FLPEYRQKES REFLSVSRTV QQVINLVYTT SAFSKFYEQS VVADVSSNNK GGLLVHFWIV 
       190        200        210        220        230        240 
FVMPRAKGHI FCEDCVAAIL KDSIQTSIIN RTSVGSLQGL AVDMDSVVLN AGLRSDYSST 
       250        260        270        280        290        300 
IGSDKGCSQY FYAEHLSLHY PLEISAASGR LMCHFKLVAI VGYLIRLSIK SIQIEADNCV 
       310        320        330        340        350        360 
TDSLTIYDSL LPIRSSILYR ICEPTRTLMS FVSTNNLMLV TFKSPHIRRL SGIRAYFEVI 
       370        380        390        400        410        420 
PEQKCENTVL VKDITGFEGK ISSPYYPSYY PPKCKCTWKF QTSLSTLGIA LKFYNYSITK 
       430        440        450        460        470        480 
KSMKGCEHGW WEINEHMYCG SYMDHQTIFR VPSPLVHIQL QCSSRLSDKP LLAEYGSYNI 
       490        500        510        520        530        540 
SQPCPVGSFR CSSGLCVPQA QRCDGVNDCF DESDELFCVS PQPACNTSSF RQHGPLICDG 
       550        560        570        580        590        600 
FRDCENGRDE QNCTQSIPCN NRTFKCGNDI CFRKQNAKCD GTVDCPDGSD EEGCTCSRSS 
       610        620        630        640        650        660 
SALHRIIGGT DTLEGGWPWQ VSLHFVGSAY CGASVISREW LLSAAHCFHG NRLSDPTPWT 
       670        680        690        700        710        720 
AHLGMYVQGN AKFVSPVRRI VVHEYYNSQT FDYDIALLQL SIAWPETLKQ LIQPICIPPT 
       730        740        750        760        770        780 
GQRVRSGEKC WVTGWGRRHE ADNKGSLVLQ QAEVELIDQT LCVSTYGIIT SRMLCAGIMS 
       790        800        810        820        830        840 
GKRDACKGDS GGPLSCRRKS DGKWILTGIV SWGHGSGRPN FPGVYTRVSN FVPWIHKYVP 
   
SLL

Isoforms

- Isoform 2 of Transmembrane protease serine 7 - Isoform 3 of Transmembrane protease serine 7

Sequence View

        10         20         30         40         50         60 
MDKENSDVSA APADLKISNI SVQVVSAQKK LPVRRPPLPG RRLPLPGRRP PQRPIGKAKP 
        70         80         90        100        110        120 
KKQSKKKVPF WNVQNKIILF TVFLFILAVI AWTLLWLYIS KTESKDAFYF AGMFRITNIE 
       130        140        150        160        170        180 
FLPEYRQKES REFLSVSRTV QQVINLVYTT SAFSKFYEQS VVADVSSNNK GGLLVHFWIV 
       190        200        210        220        230        240 
FVMPRAKGHI FCEDCVAAIL KDSIQTSIIN RTSVGSLQGL AVDMDSVVLN AGLRSDYSST 
       250        260        270        280        290        300 
IGSDKGCSQY FYAEHLSLHY PLEISAASGR LMCHFKLVAI VGYLIRLSIK SIQIEADNCV 
       310        320        330        340        350        360 
TDSLTIYDSL LPIRSSILYR ICEPTRTLMS FVSTNNLMLV TFKSPHIRRL SGIRAYFEVI 
       370        380        390        400        410        420 
PEQKCENTVL VKDITGFEGK ISSPYYPSYY PPKCKCTWKF QTSLSTLGIA LKFYNYSITK 
       430        440        450        460        470        480 
KSMKGCEHGW WEINEHMYCG SYMDHQTIFR VPSPLVHIQL QCSSRLSDKP LLAEYGSYNI 
       490        500        510        520        530        540 
SQPCPVGSFR CSSGLCVPQA QRCDGVNDCF DESDELFCVS PQPACNTSSF RQHGPLICDG 
       550        560        570        580        590        600 
FRDCENGRDE QNCTQSIPCN NRTFKCGNDI CFRKQNAKCD GTVDCPDGSD EEGCTCSRSS 
       610        620        630        640        650        660 
SALHRIIGGT DTLEGGWPWQ VSLHFVGSAY CGASVISREW LLSAAHCFHG NRLSDPTPWT 
       670        680        690        700        710        720 
AHLGMYVQGN AKFVSPVRRI VVHEYYNSQT FDYDIALLQL SIAWPETLKQ LIQPICIPPT 
       730        740        750        760        770        780 
GQRVRSGEKC WVTGWGRRHE ADNKGSLVLQ QAEVELIDQT LCVSTYGIIT SRMLCAGIMS 
       790        800        810        820        830        840 
GKRDACKGDS GGPLSCRRKS DGKWILTGIV SWGHGSGRPN FPGVYTRVSN FVPWIHKYVP 
   
SLL         10         20         30         40         50         60 
MDKENSDVSA APADLKISNI SVQVVSAQKK LPVRRPPLPG RRLPLPGRRP PQRPIGKAKP 
        70         80         90        100        110        120 
KKQSKKKVPF WNVQNKIILF TVFLFILAVI AWTLLWLYIS KTESKDAFYF AGMFRITNIE 
       130        140        150        160        170        180 
FLPEYRQKES REFLSVSRTV QQVINLVYTT SAFSKFYEQS VVADVSSNNK GGLLVHFWIV 
       190        200        210        220        230        240 
FVMPRAKGHI FCEDCVAAIL KDSIQTSIIN RTSVGSLQGL AVDMDSVVLN AGLRSDYSST 
       250        260        270        280        290        300 
IGSDKGCSQY FYAEHLSLHY PLEISAASGR LMCHFKLVAI VGYLIRLSIK SIQIEADNCV 
       310        320        330        340        350        360 
TDSLTIYDSL LPIRSSILYR ICEPTRTLMS FVSTNNLMLV TFKSPHIRRL SGIRAYFEVI 
       370        380        390        400        410        420 
PEQKCENTVL VKDITGFEGK ISSPYYPSYY PPKCKCTWKF QTSLSTLGIA LKFYNYSITK 
       430        440        450        460        470        480 
KSMKGCEHGW WEINEHMYCG SYMDHQTIFR VPSPLVHIQL QCSSRLSDKP LLAEYGSYNI 
       490        500        510        520        530        540 
SQPCPVGSFR CSSGLCVPQA QRCDGVNDCF DESDELFCVS PQPACNTSSF RQHGPLICDG 
       550        560        570        580        590        600 
FRDCENGRDE QNCTQSIPCN NRTFKCGNDI CFRKQNAKCD GTVDCPDGSD EEGCTCSRSS 
       610        620        630        640        650        660 
SALHRIIGGT DTLEGGWPWQ VSLHFVGSAY CGASVISREW LLSAAHCFHG NRLSDPTPWT 
       670        680        690        700        710        720 
AHLGMYVQGN AKFVSPVRRI VVHEYYNSQT FDYDIALLQL SIAWPETLKQ LIQPICIPPT 
       730        740        750        760        770        780 
GQRVRSGEKC WVTGWGRRHE ADNKGSLVLQ QAEVELIDQT LCVSTYGIIT SRMLCAGIMS 
       790        800        810        820        830        840 
GKRDACKGDS GGPLSCRRKS DGKWILTGIV SWGHGSGRPN FPGVYTRVSN FVPWIHKYVP 
   
SLL



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Lab:



Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 7 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q7RTY8-1-unknown MDKENS... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q7RTY8-113-unknown MFRITN... 113 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt92556
    Q7RTY8-272-unknown MCHFKL... 272 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt92557
    Q7RTY8-272-unknown MCHFKL... 272 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt103910

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates