P08697: Alpha-2-antiplasmin

General Information

Protein names	- Alpha-2-antiplasmin - Alpha-2-AP - Alpha-2-plasmin inhibitor - Alpha-2-PI - Serpin F2
Gene names	SERPINF2
Organism	Homo sapiens
Protease Family
Protease ID	I04.023
Chromosome location
UniProt ID	P08697

11 N-termini

11 C-termini

12 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MALLWGLLVL SWSCLQGPCS VFSPVSAMEP LGRQLTSGPN QEQVSPLTLL KLGNQEPGGQ
        70         80         90        100        110        120
TALKSPPGVC SRDPTPEQTH RLARAMMAFT ADLFSLVAQT STCPNLILSP LSVALALSHL
       130        140        150        160        170        180
ALGAQNHTLQ RLQQVLHAGS GPCLPHLLSR LCQDLGPGAF RLAARMYLQK GFPIKEDFLE
       190        200        210        220        230        240
QSEQLFGAKP VSLTGKQEDD LANINQWVKE ATEGKIQEFL SGLPEDTVLL LLNAIHFQGF
       250        260        270        280        290        300
WRNKFDPSLT QRDSFHLDEQ FTVPVEMMQA RTYPLRWFLL EQPEIQVAHF PFKNNMSFVV
       310        320        330        340        350        360
LVPTHFEWNV SQVLANLSWD TLHPPLVWER PTKVRLPKLY LKHQMDLVAT LSQLGLQELF
       370        380        390        400        410        420
QAPDLRGISE QSLVVSGVQH QSTLELSEVG VEAAAATSIA MSRMSLSSFS VNRPFLFFIF
       430        440        450        460        470        480
EDTTGLPLFV GSVRNPNPSA PRELKEQQDS PGNKDFLQSL KGFPRGDKLF GPDLKLVPPM
       490
EEDYPQFGSP K

Isoforms

- Isoform 2 of Alpha-2-antiplasmin

Sequence View

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Protein Neighborhood

Domains & Features

11 N-termini - 11 C-termini - 12 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P08697-1-unknown	MALLWG...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt65860
P08697-31-unknown	LGRQLT...	31	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31593
P08697-31-unknown	LGRQLT...	31	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt137624
P08697-40-unknown	NQEQVS...	40	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P08697-40-unknown	NQEQVS...	40	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31595
P08697-40-unknown	NQEQVS...	40		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P08697-47-unknown	LTLLKL...	47	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23822
P08697-396-unknown	ATSIAM...	396	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19953
P08697-396-unknown	ATSIAM...	396	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150575
P08697-398-unknown	SIAMSR...	398	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19955
P08697-398-unknown	SIAMSR...	398	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150609
P08697-401-unknown	MSRMSL...	401	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9321
P08697-401-unknown	MSRMSL...	401	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150659
P08697-402-unknown	SRMSLS...	402	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23823
P08697-402-unknown	SRMSLS...	402	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150671
P08697-404-unknown	MSLSSF...	404	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9323
P08697-404-unknown	MSLSSF...	404	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31863
P08697-404-unknown	MSLSSF...	404	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27518
P08697-404-unknown	MSLSSF...	404	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150731
P08697-444-unknown	LKEQQD...	444	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23825
P08697-444-unknown	LKEQQD...	444	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151601
P08697-460-unknown	LKGFPR...	460	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23827
P08697-460-unknown	LKGFPR...	460	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151930

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SAMEPL	30	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31593
...SAMEPL	30	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt120618
...LTSGPN	39	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31595
...LTSGPN	39	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121365
...EQVSPL	46	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23822
...EQVSPL	46	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153854
...VEAAAA	395	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19953
...VEAAAA	395	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133972
...AAAATS	397	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC19955
...AAAATS	397	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134007
...ATSIAM	400	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9321
...ATSIAM	400	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134057
...TSIAMS	401	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23823
...TSIAMS	401	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134069
...IAMSRM	403	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9323
...IAMSRM	403	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31863
...IAMSRM	403	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27518
...IAMSRM	403	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134129
...SAPREL	443	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23825
...SAPREL	443	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135007
...DFLQSL	459	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23827
...DFLQSL	459	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt135338
...FGSPK	491	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FGSPK	491	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt61478

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
SEPR_HUMAN	30	MEPL.\|.LGRQ	inferred from experiment	unknown	MEROPS	McKee PA	Lee KN et al.:Antiplasmin-cleaving enzyme is ... (S09.007)	16223769,
SEPR_HUMAN	39	SGPN.\|.NQEQ	inferred from experiment	unknown	MEROPS	McKee PA	Lee KN et al.:Antiplasmin-cleaving enzyme is ... (S09.007)	16223769,
MMP3_HUMAN	46	VSPL.\|.LTLL	inferred from experiment	unknown	MEROPS		Merops MMP3_HUMAN -> A2AP_HUMAN @46
MMP11_HUMAN	395	AAAA.\|.ATSI	inferred from experiment	unknown	MEROPS	Weiss SJ	Pei D et al.:Hydrolytic inactivation of a br... (M10.007)	7523394,
MMP11_HUMAN	397	AATS.\|.SIAM	inferred from experiment	unknown	MEROPS	Weiss SJ	Pei D et al.:Hydrolytic inactivation of a br... (M10.007)	7523394,
ELNE_HUMAN	400	SIAM.\|.MSRM	inferred from experiment	unknown	MEROPS	Travis J	Shieh BH et al.:The reactive site of human alph... (S01.131)	2437112,
MMP3_HUMAN	401	IAMS.\|.SRMS	inferred from experiment	unknown	MEROPS		Merops MMP3_HUMAN -> A2AP_HUMAN @401
ELNE_HUMAN	403	MSRM.\|.MSLS	inferred from experiment	unknown	MEROPS	Travis J	Shieh BH et al.:The reactive site of human alph... (S01.131)	2437112,
TMPS7_HUMAN	403	MSRM.\|.MSLS	inferred from experiment	unknown	MEROPS	Bugge TH	Szabo R et al.:Matriptase-3 is a novel phyloge... (S01.072)	15853774,
PLMN_HUMAN	403	MSRM.\|.MSLS	inferred from experiment	unknown	MEROPS	Collen D	Holmes WE et al.:Primary structure of human alph... (S01.233)	2433286,
MMP3_HUMAN	443	PREL.\|.LKEQ	inferred from experiment	unknown	MEROPS		Merops MMP3_HUMAN -> A2AP_HUMAN @443
MMP3_HUMAN	459	LQSL.\|.LKGF	inferred from experiment	unknown	MEROPS		Merops MMP3_HUMAN -> A2AP_HUMAN @459

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)