TopFIND 4.0

Q12884: Prolyl endopeptidase FAP {ECO:0000305}

General Information

Protein names
- Prolyl endopeptidase FAP {ECO:0000305}
- 3.4.21.26 {ECO:0000269|PubMed:16223769}
- 170 kDa melanoma membrane-bound gelatinase {ECO:0000303|PubMed:2172980, ECO:0000303|PubMed:9065413}
- Dipeptidyl peptidase FAP {ECO:0000305}
- 3.4.14.5 {ECO:0000269|PubMed:10347120}
- Fibroblast activation protein alpha {ECO:0000303|PubMed:7911242}
- FAPalpha {ECO:0000250|UniProtKB:P97321}
- Gelatine degradation protease FAP {ECO:0000305}
- 3.4.21.- {ECO:0000269|PubMed:9065413}
- Integral membrane serine protease {ECO:0000303|PubMed:9247085}
- Post-proline cleaving enzyme {ECO:0000305}
- Serine integral membrane protease {ECO:0000303|PubMed:9247085}
- SIMP {ECO:0000303|PubMed:9247085}
- Surface-expressed protease {ECO:0000303|PubMed:2172980}
- Seprase {ECO:0000303|PubMed:7923219}
- Antiplasmin-cleaving enzyme FAP, soluble form {ECO:0000303|PubMed:14751930}
- APCE {ECO:0000303|PubMed:14751930}
- 3.4.14.5 {ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16223769}
- 3.4.21.- {ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16223769}
- 3.4.21.26 {ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16223769}
Gene names FAP
Organism Homo sapiens
Protease Family S09.007
Protease ID S09.007
Chromosome location
UniProt ID Q12884

2

N-termini

1

C-termini

0

Cleavages

4

Substrates

Sequence

        10         20         30         40         50         60 
MKTWVKIVFG VATSAVLALL VMCIVLRPSR VHNSEENTMR ALTLKDILNG TFSYKTFFPN 
        70         80         90        100        110        120 
WISGQEYLHQ SADNNIVLYN IETGQSYTIL SNRTMKSVNA SNYGLSPDRQ FVYLESDYSK 
       130        140        150        160        170        180 
LWRYSYTATY YIYDLSNGEF VRGNELPRPI QYLCWSPVGS KLAYVYQNNI YLKQRPGDPP 
       190        200        210        220        230        240 
FQITFNGREN KIFNGIPDWV YEEEMLATKY ALWWSPNGKF LAYAEFNDTD IPVIAYSYYG 
       250        260        270        280        290        300 
DEQYPRTINI PYPKAGAKNP VVRIFIIDTT YPAYVGPQEV PVPAMIASSD YYFSWLTWVT 
       310        320        330        340        350        360 
DERVCLQWLK RVQNVSVLSI CDFREDWQTW DCPKTQEHIE ESRTGWAGGF FVSTPVFSYD 
       370        380        390        400        410        420 
AISYYKIFSD KDGYKHIHYI KDTVENAIQI TSGKWEAINI FRVTQDSLFY SSNEFEEYPG 
       430        440        450        460        470        480 
RRNIYRISIG SYPPSKKCVT CHLRKERCQY YTASFSDYAK YYALVCYGPG IPISTLHDGR 
       490        500        510        520        530        540 
TDQEIKILEE NKELENALKN IQLPKEEIKK LEVDEITLWY KMILPPQFDR SKKYPLLIQV 
       550        560        570        580        590        600 
YGGPCSQSVR SVFAVNWISY LASKEGMVIA LVDGRGTAFQ GDKLLYAVYR KLGVYEVEDQ 
       610        620        630        640        650        660 
ITAVRKFIEM GFIDEKRIAI WGWSYGGYVS SLALASGTGL FKCGIAVAPV SSWEYYASVY 
       670        680        690        700        710        720 
TERFMGLPTK DDNLEHYKNS TVMARAEYFR NVDYLLIHGT ADDNVHFQNS AQIAKALVNA 
       730        740        750        760    
QVDFQAMWYS DQNHGLSGLS TNHLYTHMTH FLKQCFSLSD 

Isoforms

- Isoform 2 of Seprase - Isoform 2 of Prolyl endopeptidase FAP

Sequence View

        10         20         30         40         50         60 
MKTWVKIVFG VATSAVLALL VMCIVLRPSR VHNSEENTMR ALTLKDILNG TFSYKTFFPN 
        70         80         90        100        110        120 
WISGQEYLHQ SADNNIVLYN IETGQSYTIL SNRTMKSVNA SNYGLSPDRQ FVYLESDYSK 
       130        140        150        160        170        180 
LWRYSYTATY YIYDLSNGEF VRGNELPRPI QYLCWSPVGS KLAYVYQNNI YLKQRPGDPP 
       190        200        210        220        230        240 
FQITFNGREN KIFNGIPDWV YEEEMLATKY ALWWSPNGKF LAYAEFNDTD IPVIAYSYYG 
       250        260        270        280        290        300 
DEQYPRTINI PYPKAGAKNP VVRIFIIDTT YPAYVGPQEV PVPAMIASSD YYFSWLTWVT 
       310        320        330        340        350        360 
DERVCLQWLK RVQNVSVLSI CDFREDWQTW DCPKTQEHIE ESRTGWAGGF FVSTPVFSYD 
       370        380        390        400        410        420 
AISYYKIFSD KDGYKHIHYI KDTVENAIQI TSGKWEAINI FRVTQDSLFY SSNEFEEYPG 
       430        440        450        460        470        480 
RRNIYRISIG SYPPSKKCVT CHLRKERCQY YTASFSDYAK YYALVCYGPG IPISTLHDGR 
       490        500        510        520        530        540 
TDQEIKILEE NKELENALKN IQLPKEEIKK LEVDEITLWY KMILPPQFDR SKKYPLLIQV 
       550        560        570        580        590        600 
YGGPCSQSVR SVFAVNWISY LASKEGMVIA LVDGRGTAFQ GDKLLYAVYR KLGVYEVEDQ 
       610        620        630        640        650        660 
ITAVRKFIEM GFIDEKRIAI WGWSYGGYVS SLALASGTGL FKCGIAVAPV SSWEYYASVY 
       670        680        690        700        710        720 
TERFMGLPTK DDNLEHYKNS TVMARAEYFR NVDYLLIHGT ADDNVHFQNS AQIAKALVNA 
       730        740        750        760    
QVDFQAMWYS DQNHGLSGLS TNHLYTHMTH FLKQCFSLSD          10         20         30         40         50         60 
MKTWVKIVFG VATSAVLALL VMCIVLRPSR VHNSEENTMR ALTLKDILNG TFSYKTFFPN 
        70         80         90        100        110        120 
WISGQEYLHQ SADNNIVLYN IETGQSYTIL SNRTMKSVNA SNYGLSPDRQ FVYLESDYSK 
       130        140        150        160        170        180 
LWRYSYTATY YIYDLSNGEF VRGNELPRPI QYLCWSPVGS KLAYVYQNNI YLKQRPGDPP 
       190        200        210        220        230        240 
FQITFNGREN KIFNGIPDWV YEEEMLATKY ALWWSPNGKF LAYAEFNDTD IPVIAYSYYG 
       250        260        270        280        290        300 
DEQYPRTINI PYPKAGAKNP VVRIFIIDTT YPAYVGPQEV PVPAMIASSD YYFSWLTWVT 
       310        320        330        340        350        360 
DERVCLQWLK RVQNVSVLSI CDFREDWQTW DCPKTQEHIE ESRTGWAGGF FVSTPVFSYD 
       370        380        390        400        410        420 
AISYYKIFSD KDGYKHIHYI KDTVENAIQI TSGKWEAINI FRVTQDSLFY SSNEFEEYPG 
       430        440        450        460        470        480 
RRNIYRISIG SYPPSKKCVT CHLRKERCQY YTASFSDYAK YYALVCYGPG IPISTLHDGR 
       490        500        510        520        530        540 
TDQEIKILEE NKELENALKN IQLPKEEIKK LEVDEITLWY KMILPPQFDR SKKYPLLIQV 
       550        560        570        580        590        600 
YGGPCSQSVR SVFAVNWISY LASKEGMVIA LVDGRGTAFQ GDKLLYAVYR KLGVYEVEDQ 
       610        620        630        640        650        660 
ITAVRKFIEM GFIDEKRIAI WGWSYGGYVS SLALASGTGL FKCGIAVAPV SSWEYYASVY 
       670        680        690        700        710        720 
TERFMGLPTK DDNLEHYKNS TVMARAEYFR NVDYLLIHGT ADDNVHFQNS AQIAKALVNA 
       730        740        750        760    
QVDFQAMWYS DQNHGLSGLS TNHLYTHMTH FLKQCFSLSD 



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 4 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q12884-1-unknown MKTWVK... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q12884-522-unknown MILPPQ... 522 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt89273

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...FSLSD 760 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...FSLSD 760 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt84891

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates