P05546: Heparin cofactor 2

General Information

Protein names	- Heparin cofactor 2 - Heparin cofactor II - HC-II - Protease inhibitor leuserpin-2 - HLS2 - Serpin D1
Gene names	SERPIND1
Organism	Homo sapiens
Protease Family
Protease ID	I04.019
Chromosome location
UniProt ID	P05546

8 N-termini

4 C-termini

7 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKHSLNALLI FLIITSAWGG SKGPLDQLEK GGETAQSADP QWEQLNNKNL SMPLLPADFH
        70         80         90        100        110        120
KENTVTNDWI PEGEEDDDYL DLEKIFSEDD DYIDIVDSLS VSPTDSDVSA GNILQLFHGK
       130        140        150        160        170        180
SRIQRLNILN AKFAFNLYRV LKDQVNTFDN IFIAPVGIST AMGMISLGLK GETHEQVHSI
       190        200        210        220        230        240
LHFKDFVNAS SKYEITTIHN LFRKLTHRLF RRNFGYTLRS VNDLYIQKQF PILLDFKTKV
       250        260        270        280        290        300
REYYFAEAQI ADFSDPAFIS KTNNHIMKLT KGLIKDALEN IDPATQMMIL NCIYFKGSWV
       310        320        330        340        350        360
NKFPVEMTHN HNFRLNEREV VKVSMMQTKG NFLAANDQEL DCDILQLEYV GGISMLIVVP
       370        380        390        400        410        420
HKMSGMKTLE AQLTPRVVER WQKSMTNRTR EVLLPKFKLE KNYNLVESLK LMGIRMLFDK
       430        440        450        460        470        480
NGNMAGISDQ RIAIDLFKHQ GTITVNEEGT QATTVTTVGF MPLSTQVRFT VDRPFLFLIY
       490
EHRTSCLLFM GRVANPSRS

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

8 N-termini - 4 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P05546-20-unknown	GSKGPL...	20	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P05546-20-unknown	GSKGPL...	20		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P05546-31-unknown	GGETAQ...	31		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P05546-37-unknown	SADPQW...	37		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P05546-86-unknown	FSEDDD...	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9286
P05546-86-unknown	FSEDDD...	86	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4770
P05546-220-unknown	SVNDLY...	220		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P05546-422-unknown	GNMAGI...	422		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P05546-459-unknown	GFMPLS...	459	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9287
P05546-459-unknown	GFMPLS...	459	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4771
P05546-464-unknown	STQVRF...	464	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31749
P05546-464-unknown	STQVRF...	464	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31862
P05546-464-unknown	STQVRF...	464	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8444

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DLEKIF	85	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9286
...DLEKIF	85	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4770
...TVTTVG	458	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9287
...TVTTVG	458	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4771
...GFMPLS	463	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31749
...GFMPLS	463	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31862
...GFMPLS	463	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8444
...NPSRS	499	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ELNE_HUMAN	85	EKIF.\|.FSED	inferred from experiment	unknown	MEROPS	Church FC	Pratt CW et al.:Interaction of heparin cofactor... (S01.133)	2318847,
CATG_HUMAN	85	EKIF.\|.FSED	inferred from experiment	unknown	MEROPS	Church FC	Pratt CW et al.:Interaction of heparin cofactor... (S01.133)	2318847,
ELNE_HUMAN	458	TTVG.\|.GFMP	inferred from experiment	unknown	MEROPS	Church FC	Pratt CW et al.:Interaction of heparin cofactor... (S01.133)	2318847,
CATG_HUMAN	458	TTVG.\|.GFMP	inferred from experiment	unknown	MEROPS	Church FC	Pratt CW et al.:Interaction of heparin cofactor... (S01.133)	2318847,
THRB_HUMAN	463	MPLS.\|.STQV	inferred from experiment	unknown	MEROPS	Church FC	Griffith MJ et al.:Reactive site peptide structura... (S01.217)	3838304,
TMPS7_HUMAN	463	MPLS.\|.STQV	inferred from experiment	unknown	MEROPS	Bugge TH	Szabo R et al.:Matriptase-3 is a novel phyloge... (S01.072)	15853774,
CTRB2_HUMAN	463	MPLS.\|.STQV	inferred from experiment	unknown	MEROPS	Griffith MJ	Church FC et al.:Inhibition of chymotrypsin by h... (S01.152)	3863104,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)