P05154: Plasma serine protease inhibitor

General Information

Protein names	- Plasma serine protease inhibitor - Acrosomal serine protease inhibitor - Plasminogen activator inhibitor 3 - PAI-3 - PAI3 - Protein C inhibitor - PCI - Serpin A5
Gene names	SERPINA5
Organism	Homo sapiens
Protease Family
Protease ID	I04.004
Chromosome location
UniProt ID	P05154

2 N-termini

9 C-termini

2 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MQLFLLLCLV LLSPQGASLH RHHPREMKKR VEDLHVGATV APSSRRDFTF DLYRALASAA
        70         80         90        100        110        120
PSQSIFFSPV SISMSLAMLS LGAGSSTKMQ ILEGLGLNLQ KSSEKELHRG FQQLLQELNQ
       130        140        150        160        170        180
PRDGFQLSLG NALFTDLVVD LQDTFVSAMK TLYLADTFPT NFRDSAGAMK QINDYVAKQT
       190        200        210        220        230        240
KGKIVDLLKN LDSNAVVIMV NYIFFKAKWE TSFNHKGTQE QDFYVTSETV VRVPMMSRED
       250        260        270        280        290        300
QYHYLLDRNL SCRVVGVPYQ GNATALFILP SEGKMQQVEN GLSEKTLRKW LKMFKKRQLE
       310        320        330        340        350        360
LYLPKFSIEG SYQLEKVLPS LGISNVFTSH ADLSGISNHS NIQVSEMVHK AVVEVDESGT
       370        380        390        400
RAAAATGTIF TFRSARLNSQ RLVFNRPFLM FIVDNNILFL GKVNRP

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 9 C-termini - 2 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P05154-26-unknown	EMKKRV...	26	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P05154-374-unknown	SARLNS...	374	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31861
P05154-374-unknown	SARLNS...	374	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16077

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HRHHPR	24	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000451487
...GAGSST	86	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000451697
...STKMQI	90	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000451215
...DLQDTF	144	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000451650
...YLADTF	157	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450485
...AMKQIN	172	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450484
...SETVVR	231	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000450745
...IFTFRS	373	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31861
...IFTFRS	373	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16077
...KVNRP	406	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
TMPS7_HUMAN	373	TFRS.\|.SARL	inferred from experiment	unknown	MEROPS	Bugge TH	Szabo R et al.:Matriptase-3 is a novel phyloge... (S01.072)	15853774,
KLK2_HUMAN	373	TFRS.\|.SARL	inferred from experiment	unknown	MEROPS	Saedi MS	Mikolajczyk SD et al.:Prostatic human kallikrein 2 in... (S01.161)	10209959,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)