P01008: Antithrombin-III

General Information

Protein names	- Antithrombin-III - ATIII - Serpin C1
Gene names	SERPINC1
Organism	Homo sapiens
Protease Family
Protease ID	I04.018
Chromosome location
UniProt ID	P01008

9 N-termini

3 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MYSNVIGTVT SGKRKVYLLS LLLIGFWDCV TCHGSPVDIC TAKPRDIPMN PMCIYRSPEK
        70         80         90        100        110        120
KATEDEGSEQ KIPEATNRRV WELSKANSRF ATTFYQHLAD SKNDNDNIFL SPLSISTAFA
       130        140        150        160        170        180
MTKLGACNDT LQQLMEVFKF DTISEKTSDQ IHFFFAKLNC RLYRKANKSS KLVSANRLFG
       190        200        210        220        230        240
DKSLTFNETY QDISELVYGA KLQPLDFKEN AEQSRAAINK WVSNKTEGRI TDVIPSEAIN
       250        260        270        280        290        300
ELTVLVLVNT IYFKGLWKSK FSPENTRKEL FYKADGESCS ASMMYQEGKF RYRRVAEGTQ
       310        320        330        340        350        360
VLELPFKGDD ITMVLILPKP EKSLAKVEKE LTPEVLQEWL DELEEMMLVV HMPRFRIEDG
       370        380        390        400        410        420
FSLKEQLQDM GLVDLFSPEK SKLPGIVAEG RDDLYVSDAF HKAFLEVNEE GSEAAASTAV
       430        440        450        460
VIAGRSLNPN RVTFKANRPF LVFIREVPLN TIIFMGRVAN PCVK

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

9 N-termini - 3 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
P01008-33-unknown	HGSPVD...	33	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P01008-33-unknown	HGSPVD...	33		unknown		Mahrus S. et al.: apototic Jurkat cells, Global Sequencing of Proteolytic Cleavage...	18722006
P01008-33-unknown	HGSPVD...	33		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01008-34-unknown	GSPVDI...	34		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01008-35-unknown	SPVDIC...	35		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01008-62-unknown	ATEDEG...	62		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01008-80-unknown	VWELSK...	80		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01008-90-unknown	FATTFY...	90		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01008-417-unknown	STAVVI...	417		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P01008-423-unknown	AGRSLN...	423	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8631
P01008-426-unknown	SLNPNR...	426	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23657
P01008-426-unknown	SLNPNR...	426	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31858
P01008-426-unknown	SLNPNR...	426	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31736
P01008-426-unknown	SLNPNR...	426		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TAVVIA	422	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC8631
...VIAGRS	425	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC23657
...VIAGRS	425	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31858
...VIAGRS	425	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31736
...NPCVK	464	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
ELNE_HUMAN	422	VVIA.\|.AGRS	inferred from experiment	unknown	MEROPS	Carrell RW	Chang WS et al.:Probing serpin reactive-loop co... (S01.131)	8670081,
MMP3_HUMAN	425	AGRS.\|.SLNP	inferred from experiment	unknown	MEROPS	Salvesen G	Mast AE et al.:Kinetics and physiologic releva... (M10.001)	1651920,
TMPS7_HUMAN	425	AGRS.\|.SLNP	inferred from experiment	unknown	MEROPS	Bugge TH	Szabo R et al.:Matriptase-3 is a novel phyloge... (S01.072)	15853774,
THRB_HUMAN	425	AGRS.\|.SLNP	inferred from experiment	unknown	MEROPS	Jornvall	Bjork I et al.:The site in human antithrombin ... (S01.217)	7238875,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)