TopFIND 4.0

P00750: Tissue-type plasminogen activator

General Information

Protein names
- Tissue-type plasminogen activator
- t-PA
- t-plasminogen activator
- tPA
- 3.4.21.68
- Alteplase
- Reteplase
- Tissue-type plasminogen activator chain A
- Tissue-type plasminogen activator chain B
Gene names PLAT
Organism Homo sapiens
Protease Family S01.232
Protease ID S01.232
Chromosome location
UniProt ID P00750

3

N-termini

2

C-termini

3

Cleavages

14

Substrates

Sequence

        10         20         30         40         50         60 
MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY QQHQSWLRPV 
        70         80         90        100        110        120 
LRSNRVEYCW CNSGRAQCHS VPVKSCSEPR CFNGGTCQQA LYFSDFVCQC PEGFAGKCCE 
       130        140        150        160        170        180 
IDTRATCYED QGISYRGTWS TAESGAECTN WNSSALAQKP YSGRRPDAIR LGLGNHNYCR 
       190        200        210        220        230        240 
NPDRDSKPWC YVFKAGKYSS EFCSTPACSE GNSDCYFGNG SAYRGTHSLT ESGASCLPWN 
       250        260        270        280        290        300 
SMILIGKVYT AQNPSAQALG LGKHNYCRNP DGDAKPWCHV LKNRRLTWEY CDVPSCSTCG 
       310        320        330        340        350        360 
LRQYSQPQFR IKGGLFADIA SHPWQAAIFA KHRRSPGERF LCGGILISSC WILSAAHCFQ 
       370        380        390        400        410        420 
ERFPPHHLTV ILGRTYRVVP GEEEQKFEVE KYIVHKEFDD DTYDNDIALL QLKSDSSRCA 
       430        440        450        460        470        480 
QESSVVRTVC LPPADLQLPD WTECELSGYG KHEALSPFYS ERLKEAHVRL YPSSRCTSQH 
       490        500        510        520        530        540 
LLNRTVTDNM LCAGDTRSGG PQANLHDACQ GDSGGPLVCL NDGRMTLVGI ISWGLGCGQK 
       550        560    
DVPGVYTKVT NYLDWIRDNM RP

Isoforms

- Isoform 2 of Tissue-type plasminogen activator - Isoform 3 of Tissue-type plasminogen activator - Isoform 4 of Tissue-type plasminogen activator

Sequence View

        10         20         30         40         50         60 
MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY QQHQSWLRPV 
        70         80         90        100        110        120 
LRSNRVEYCW CNSGRAQCHS VPVKSCSEPR CFNGGTCQQA LYFSDFVCQC PEGFAGKCCE 
       130        140        150        160        170        180 
IDTRATCYED QGISYRGTWS TAESGAECTN WNSSALAQKP YSGRRPDAIR LGLGNHNYCR 
       190        200        210        220        230        240 
NPDRDSKPWC YVFKAGKYSS EFCSTPACSE GNSDCYFGNG SAYRGTHSLT ESGASCLPWN 
       250        260        270        280        290        300 
SMILIGKVYT AQNPSAQALG LGKHNYCRNP DGDAKPWCHV LKNRRLTWEY CDVPSCSTCG 
       310        320        330        340        350        360 
LRQYSQPQFR IKGGLFADIA SHPWQAAIFA KHRRSPGERF LCGGILISSC WILSAAHCFQ 
       370        380        390        400        410        420 
ERFPPHHLTV ILGRTYRVVP GEEEQKFEVE KYIVHKEFDD DTYDNDIALL QLKSDSSRCA 
       430        440        450        460        470        480 
QESSVVRTVC LPPADLQLPD WTECELSGYG KHEALSPFYS ERLKEAHVRL YPSSRCTSQH 
       490        500        510        520        530        540 
LLNRTVTDNM LCAGDTRSGG PQANLHDACQ GDSGGPLVCL NDGRMTLVGI ISWGLGCGQK 
       550        560    
DVPGVYTKVT NYLDWIRDNM RP         10         20         30         40         50         60 
MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY QQHQSWLRPV 
        70         80         90        100        110        120 
LRSNRVEYCW CNSGRAQCHS VPVKSCSEPR CFNGGTCQQA LYFSDFVCQC PEGFAGKCCE 
       130        140        150        160        170        180 
IDTRATCYED QGISYRGTWS TAESGAECTN WNSSALAQKP YSGRRPDAIR LGLGNHNYCR 
       190        200        210        220        230        240 
NPDRDSKPWC YVFKAGKYSS EFCSTPACSE GNSDCYFGNG SAYRGTHSLT ESGASCLPWN 
       250        260        270        280        290        300 
SMILIGKVYT AQNPSAQALG LGKHNYCRNP DGDAKPWCHV LKNRRLTWEY CDVPSCSTCG 
       310        320        330        340        350        360 
LRQYSQPQFR IKGGLFADIA SHPWQAAIFA KHRRSPGERF LCGGILISSC WILSAAHCFQ 
       370        380        390        400        410        420 
ERFPPHHLTV ILGRTYRVVP GEEEQKFEVE KYIVHKEFDD DTYDNDIALL QLKSDSSRCA 
       430        440        450        460        470        480 
QESSVVRTVC LPPADLQLPD WTECELSGYG KHEALSPFYS ERLKEAHVRL YPSSRCTSQH 
       490        500        510        520        530        540 
LLNRTVTDNM LCAGDTRSGG PQANLHDACQ GDSGGPLVCL NDGRMTLVGI ISWGLGCGQK 
       550        560    
DVPGVYTKVT NYLDWIRDNM RP         10         20         30         40         50         60 
MDAMKRGLCC VLLLCGAVFV SPSQEIHARF RRGARSYQVI CRDEKTQMIY QQHQSWLRPV 
        70         80         90        100        110        120 
LRSNRVEYCW CNSGRAQCHS VPVKSCSEPR CFNGGTCQQA LYFSDFVCQC PEGFAGKCCE 
       130        140        150        160        170        180 
IDTRATCYED QGISYRGTWS TAESGAECTN WNSSALAQKP YSGRRPDAIR LGLGNHNYCR 
       190        200        210        220        230        240 
NPDRDSKPWC YVFKAGKYSS EFCSTPACSE GNSDCYFGNG SAYRGTHSLT ESGASCLPWN 
       250        260        270        280        290        300 
SMILIGKVYT AQNPSAQALG LGKHNYCRNP DGDAKPWCHV LKNRRLTWEY CDVPSCSTCG 
       310        320        330        340        350        360 
LRQYSQPQFR IKGGLFADIA SHPWQAAIFA KHRRSPGERF LCGGILISSC WILSAAHCFQ 
       370        380        390        400        410        420 
ERFPPHHLTV ILGRTYRVVP GEEEQKFEVE KYIVHKEFDD DTYDNDIALL QLKSDSSRCA 
       430        440        450        460        470        480 
QESSVVRTVC LPPADLQLPD WTECELSGYG KHEALSPFYS ERLKEAHVRL YPSSRCTSQH 
       490        500        510        520        530        540 
LLNRTVTDNM LCAGDTRSGG PQANLHDACQ GDSGGPLVCL NDGRMTLVGI ISWGLGCGQK 
       550        560    
DVPGVYTKVT NYLDWIRDNM RP



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 3 Cleavages - 14 Substrates

N-termini

C-termini

Cleavages

Substrates