Q05586: Glutamate receptor ionotropic, NMDA 1

General Information

Protein names	- Glutamate receptor ionotropic, NMDA 1 - GluN1 - Glutamate NMDA] receptor subunit zeta-1 - N-methyl-D-aspartate receptor subunit NR1 - NMD-R1
Gene names	GRIN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q05586

3 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 1 of Glutamate receptor ionotropic, NMDA 1 - Isoform 2 of Glutamate receptor ionotropic, NMDA 1 - Isoform 4 of Glutamate receptor ionotropic, NMDA 1 - Isoform 5 of Glutamate receptor ionotropic, NMDA 1 - Isoform 6 of Glutamate receptor ionotropic, NMDA 1 - Isoform 7 of Glutamate receptor ionotropic, NMDA 1

Sequence View

        10         20         30         40         50         60
MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN KRHGSWKIQL
        70         80         90        100        110        120
NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND HFTPTPVSYT AGFYRIPVLG
       130        140        150        160        170        180
LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV WFEMMRVYSW NHIILLVSDD HEGRAAQKRL
       190        200        210        220        230        240
ETLLEERESK AEKVLQFDPG TKNVTALLME AKELEARVII LSASEDDAAT VYRAAAMLNM
       250        260        270        280        290        300
TGSGYVWLVG EREISGNALR YAPDGILGLQ LINGKNESAH ISDAVGVVAQ AVHELLEKEN
       310        320        330        340        350        360
ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY ADGVTGRVEF NEDGDRKFAN YSIMNLQNRK
       370        380        390        400        410        420
LVQVGIYNGT HVIPNDRKII WPGGETEKPR GYQMSTRLKI VTIHQEPFVY VKPTLSDGTC
       430        440        450        460        470        480
KEEFTVNGDP VKKVICTGPN DTSPGSPRHT VPQCCYGFCI DLLIKLARTM NFTYEVHLVA
       490        500        510        520        530        540
DGKFGTQERV NNSNKKEWNG MMGELLSGQA DMIVAPLTIN NERAQYIEFS KPFKYQGLTI
       550        560        570        580        590        600
LVKKEIPRST LDSFMQPFQS TLWLLVGLSV HVVAVMLYLL DRFSPFGRFK VNSEEEEEDA
       610        620        630        640        650        660
LTLSSAMWFS WGVLLNSGIG EGAPRSFSAR ILGMVWAGFA MIIVASYTAN LAAFLVLDRP
       670        680        690        700        710        720
EERITGINDP RLRNPSDKFI YATVKQSSVD IYFRRQVELS TMYRHMEKHN YESAAEAIQA
       730        740        750        760        770        780
VRDNKLHAFI WDSAVLEFEA SQKCDLVTTG ELFFRSGFGI GMRKDSPWKQ NVSLSILKSH
       790        800        810        820        830        840
ENGFMEDLDK TWVRYQECDS RSNAPATLTF ENMAGVFMLV AGGIVAGIFL IFIEIAYKRH
       850        860        870        880        890        900
KDARRKQMQL AFAAVNVWRK NLQDRKSGRA EPDPKKKATF RAITSTLASS FKRRRSSKDT
       910        920        930
STGGGRGALQ NQKDTVLPRR AIEREEGQLQ LCSRHRES         10         20         30         40         50         60
MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN KRHGSWKIQL
        70         80         90        100        110        120
NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND HFTPTPVSYT AGFYRIPVLG
       130        140        150        160        170        180
LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV WFEMMRVYSW NHIILLVSDD HEGRAAQKRL
       190        200        210        220        230        240
ETLLEERESK AEKVLQFDPG TKNVTALLME AKELEARVII LSASEDDAAT VYRAAAMLNM
       250        260        270        280        290        300
TGSGYVWLVG EREISGNALR YAPDGILGLQ LINGKNESAH ISDAVGVVAQ AVHELLEKEN
       310        320        330        340        350        360
ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY ADGVTGRVEF NEDGDRKFAN YSIMNLQNRK
       370        380        390        400        410        420
LVQVGIYNGT HVIPNDRKII WPGGETEKPR GYQMSTRLKI VTIHQEPFVY VKPTLSDGTC
       430        440        450        460        470        480
KEEFTVNGDP VKKVICTGPN DTSPGSPRHT VPQCCYGFCI DLLIKLARTM NFTYEVHLVA
       490        500        510        520        530        540
DGKFGTQERV NNSNKKEWNG MMGELLSGQA DMIVAPLTIN NERAQYIEFS KPFKYQGLTI
       550        560        570        580        590        600
LVKKEIPRST LDSFMQPFQS TLWLLVGLSV HVVAVMLYLL DRFSPFGRFK VNSEEEEEDA
       610        620        630        640        650        660
LTLSSAMWFS WGVLLNSGIG EGAPRSFSAR ILGMVWAGFA MIIVASYTAN LAAFLVLDRP
       670        680        690        700        710        720
EERITGINDP RLRNPSDKFI YATVKQSSVD IYFRRQVELS TMYRHMEKHN YESAAEAIQA
       730        740        750        760        770        780
VRDNKLHAFI WDSAVLEFEA SQKCDLVTTG ELFFRSGFGI GMRKDSPWKQ NVSLSILKSH
       790        800        810        820        830        840
ENGFMEDLDK TWVRYQECDS RSNAPATLTF ENMAGVFMLV AGGIVAGIFL IFIEIAYKRH
       850        860        870        880        890        900
KDARRKQMQL AFAAVNVWRK NLQDRKSGRA EPDPKKKATF RAITSTLASS FKRRRSSKDT
       910        920        930
STGGGRGALQ NQKDTVLPRR AIEREEGQLQ LCSRHRES         10         20         30         40         50         60
MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN KRHGSWKIQL
        70         80         90        100        110        120
NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND HFTPTPVSYT AGFYRIPVLG
       130        140        150        160        170        180
LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV WFEMMRVYSW NHIILLVSDD HEGRAAQKRL
       190        200        210        220        230        240
ETLLEERESK AEKVLQFDPG TKNVTALLME AKELEARVII LSASEDDAAT VYRAAAMLNM
       250        260        270        280        290        300
TGSGYVWLVG EREISGNALR YAPDGILGLQ LINGKNESAH ISDAVGVVAQ AVHELLEKEN
       310        320        330        340        350        360
ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY ADGVTGRVEF NEDGDRKFAN YSIMNLQNRK
       370        380        390        400        410        420
LVQVGIYNGT HVIPNDRKII WPGGETEKPR GYQMSTRLKI VTIHQEPFVY VKPTLSDGTC
       430        440        450        460        470        480
KEEFTVNGDP VKKVICTGPN DTSPGSPRHT VPQCCYGFCI DLLIKLARTM NFTYEVHLVA
       490        500        510        520        530        540
DGKFGTQERV NNSNKKEWNG MMGELLSGQA DMIVAPLTIN NERAQYIEFS KPFKYQGLTI
       550        560        570        580        590        600
LVKKEIPRST LDSFMQPFQS TLWLLVGLSV HVVAVMLYLL DRFSPFGRFK VNSEEEEEDA
       610        620        630        640        650        660
LTLSSAMWFS WGVLLNSGIG EGAPRSFSAR ILGMVWAGFA MIIVASYTAN LAAFLVLDRP
       670        680        690        700        710        720
EERITGINDP RLRNPSDKFI YATVKQSSVD IYFRRQVELS TMYRHMEKHN YESAAEAIQA
       730        740        750        760        770        780
VRDNKLHAFI WDSAVLEFEA SQKCDLVTTG ELFFRSGFGI GMRKDSPWKQ NVSLSILKSH
       790        800        810        820        830        840
ENGFMEDLDK TWVRYQECDS RSNAPATLTF ENMAGVFMLV AGGIVAGIFL IFIEIAYKRH
       850        860        870        880        890        900
KDARRKQMQL AFAAVNVWRK NLQDRKSGRA EPDPKKKATF RAITSTLASS FKRRRSSKDT
       910        920        930
STGGGRGALQ NQKDTVLPRR AIEREEGQLQ LCSRHRES         10         20         30         40         50         60
MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN KRHGSWKIQL
        70         80         90        100        110        120
NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND HFTPTPVSYT AGFYRIPVLG
       130        140        150        160        170        180
LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV WFEMMRVYSW NHIILLVSDD HEGRAAQKRL
       190        200        210        220        230        240
ETLLEERESK AEKVLQFDPG TKNVTALLME AKELEARVII LSASEDDAAT VYRAAAMLNM
       250        260        270        280        290        300
TGSGYVWLVG EREISGNALR YAPDGILGLQ LINGKNESAH ISDAVGVVAQ AVHELLEKEN
       310        320        330        340        350        360
ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY ADGVTGRVEF NEDGDRKFAN YSIMNLQNRK
       370        380        390        400        410        420
LVQVGIYNGT HVIPNDRKII WPGGETEKPR GYQMSTRLKI VTIHQEPFVY VKPTLSDGTC
       430        440        450        460        470        480
KEEFTVNGDP VKKVICTGPN DTSPGSPRHT VPQCCYGFCI DLLIKLARTM NFTYEVHLVA
       490        500        510        520        530        540
DGKFGTQERV NNSNKKEWNG MMGELLSGQA DMIVAPLTIN NERAQYIEFS KPFKYQGLTI
       550        560        570        580        590        600
LVKKEIPRST LDSFMQPFQS TLWLLVGLSV HVVAVMLYLL DRFSPFGRFK VNSEEEEEDA
       610        620        630        640        650        660
LTLSSAMWFS WGVLLNSGIG EGAPRSFSAR ILGMVWAGFA MIIVASYTAN LAAFLVLDRP
       670        680        690        700        710        720
EERITGINDP RLRNPSDKFI YATVKQSSVD IYFRRQVELS TMYRHMEKHN YESAAEAIQA
       730        740        750        760        770        780
VRDNKLHAFI WDSAVLEFEA SQKCDLVTTG ELFFRSGFGI GMRKDSPWKQ NVSLSILKSH
       790        800        810        820        830        840
ENGFMEDLDK TWVRYQECDS RSNAPATLTF ENMAGVFMLV AGGIVAGIFL IFIEIAYKRH
       850        860        870        880        890        900
KDARRKQMQL AFAAVNVWRK NLQDRKSGRA EPDPKKKATF RAITSTLASS FKRRRSSKDT
       910        920        930
STGGGRGALQ NQKDTVLPRR AIEREEGQLQ LCSRHRES         10         20         30         40         50         60
MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN KRHGSWKIQL
        70         80         90        100        110        120
NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND HFTPTPVSYT AGFYRIPVLG
       130        140        150        160        170        180
LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV WFEMMRVYSW NHIILLVSDD HEGRAAQKRL
       190        200        210        220        230        240
ETLLEERESK AEKVLQFDPG TKNVTALLME AKELEARVII LSASEDDAAT VYRAAAMLNM
       250        260        270        280        290        300
TGSGYVWLVG EREISGNALR YAPDGILGLQ LINGKNESAH ISDAVGVVAQ AVHELLEKEN
       310        320        330        340        350        360
ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY ADGVTGRVEF NEDGDRKFAN YSIMNLQNRK
       370        380        390        400        410        420
LVQVGIYNGT HVIPNDRKII WPGGETEKPR GYQMSTRLKI VTIHQEPFVY VKPTLSDGTC
       430        440        450        460        470        480
KEEFTVNGDP VKKVICTGPN DTSPGSPRHT VPQCCYGFCI DLLIKLARTM NFTYEVHLVA
       490        500        510        520        530        540
DGKFGTQERV NNSNKKEWNG MMGELLSGQA DMIVAPLTIN NERAQYIEFS KPFKYQGLTI
       550        560        570        580        590        600
LVKKEIPRST LDSFMQPFQS TLWLLVGLSV HVVAVMLYLL DRFSPFGRFK VNSEEEEEDA
       610        620        630        640        650        660
LTLSSAMWFS WGVLLNSGIG EGAPRSFSAR ILGMVWAGFA MIIVASYTAN LAAFLVLDRP
       670        680        690        700        710        720
EERITGINDP RLRNPSDKFI YATVKQSSVD IYFRRQVELS TMYRHMEKHN YESAAEAIQA
       730        740        750        760        770        780
VRDNKLHAFI WDSAVLEFEA SQKCDLVTTG ELFFRSGFGI GMRKDSPWKQ NVSLSILKSH
       790        800        810        820        830        840
ENGFMEDLDK TWVRYQECDS RSNAPATLTF ENMAGVFMLV AGGIVAGIFL IFIEIAYKRH
       850        860        870        880        890        900
KDARRKQMQL AFAAVNVWRK NLQDRKSGRA EPDPKKKATF RAITSTLASS FKRRRSSKDT
       910        920        930
STGGGRGALQ NQKDTVLPRR AIEREEGQLQ LCSRHRES         10         20         30         40         50         60
MSTMRLLTLA LLFSCSVARA ACDPKIVNIG AVLSTRKHEQ MFREAVNQAN KRHGSWKIQL
        70         80         90        100        110        120
NATSVTHKPN AIQMALSVCE DLISSQVYAI LVSHPPTPND HFTPTPVSYT AGFYRIPVLG
       130        140        150        160        170        180
LTTRMSIYSD KSIHLSFLRT VPPYSHQSSV WFEMMRVYSW NHIILLVSDD HEGRAAQKRL
       190        200        210        220        230        240
ETLLEERESK AEKVLQFDPG TKNVTALLME AKELEARVII LSASEDDAAT VYRAAAMLNM
       250        260        270        280        290        300
TGSGYVWLVG EREISGNALR YAPDGILGLQ LINGKNESAH ISDAVGVVAQ AVHELLEKEN
       310        320        330        340        350        360
ITDPPRGCVG NTNIWKTGPL FKRVLMSSKY ADGVTGRVEF NEDGDRKFAN YSIMNLQNRK
       370        380        390        400        410        420
LVQVGIYNGT HVIPNDRKII WPGGETEKPR GYQMSTRLKI VTIHQEPFVY VKPTLSDGTC
       430        440        450        460        470        480
KEEFTVNGDP VKKVICTGPN DTSPGSPRHT VPQCCYGFCI DLLIKLARTM NFTYEVHLVA
       490        500        510        520        530        540
DGKFGTQERV NNSNKKEWNG MMGELLSGQA DMIVAPLTIN NERAQYIEFS KPFKYQGLTI
       550        560        570        580        590        600
LVKKEIPRST LDSFMQPFQS TLWLLVGLSV HVVAVMLYLL DRFSPFGRFK VNSEEEEEDA
       610        620        630        640        650        660
LTLSSAMWFS WGVLLNSGIG EGAPRSFSAR ILGMVWAGFA MIIVASYTAN LAAFLVLDRP
       670        680        690        700        710        720
EERITGINDP RLRNPSDKFI YATVKQSSVD IYFRRQVELS TMYRHMEKHN YESAAEAIQA
       730        740        750        760        770        780
VRDNKLHAFI WDSAVLEFEA SQKCDLVTTG ELFFRSGFGI GMRKDSPWKQ NVSLSILKSH
       790        800        810        820        830        840
ENGFMEDLDK TWVRYQECDS RSNAPATLTF ENMAGVFMLV AGGIVAGIFL IFIEIAYKRH
       850        860        870        880        890        900
KDARRKQMQL AFAAVNVWRK NLQDRKSGRA EPDPKKKATF RAITSTLASS FKRRRSSKDT
       910        920        930
STGGGRGALQ NQKDTVLPRR AIEREEGQLQ LCSRHRES

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q05586-1-unknown	MSTMRL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82966
Q05586-1-unknown	MSTMRL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82967
Q05586-1-unknown	MSTMRL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82968
Q05586-1-unknown	MSTMRL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82969
Q05586-1-unknown	MSTMRL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82970
Q05586-1-unknown	MSTMRL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt82971
Q05586-19-unknown	RAACDP...	19	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q05586-19-unknown	RAACDP...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112179
Q05586-19-unknown	RAACDP...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112180
Q05586-19-unknown	RAACDP...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112181
Q05586-19-unknown	RAACDP...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112182
Q05586-19-unknown	RAACDP...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112183
Q05586-19-unknown	RAACDP...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112184
Q05586-261-unknown	YAPDGI...	261	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31871
Q05586-261-unknown	YAPDGI...	261	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148852
Q05586-261-unknown	YAPDGI...	261	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148855
Q05586-261-unknown	YAPDGI...	261	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148857
Q05586-261-unknown	YAPDGI...	261	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149397
Q05586-261-unknown	YAPDGI...	261	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149398
Q05586-261-unknown	YAPDGI...	261	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149399

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...GNALRY	260	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31871
...GNALRY	260	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132229
...GNALRY	260	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132232
...GNALRY	260	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132234
...GNALRY	260	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132782
...GNALRY	260	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132783
...GNALRY	260	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132784
...RHRES	938	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RHRES	938	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78585
...RHRES	938	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt78587

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
TPA_HUMAN	260	ALRY.\|.YAPD	inferred from experiment	unknown	MEROPS	Vivien D	Fernandez-Monreal M et al.:Arginine 260 of the amino-termi... (S01.232)	15448144,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)