Q99574: Neuroserpin

General Information

Protein names	- Neuroserpin - Peptidase inhibitor 12 - PI-12 - Serpin I1
Gene names	SERPINI1
Organism	Homo sapiens
Protease Family
Protease ID	I04.025
Chromosome location
UniProt ID	Q99574

2 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAFLGLFSLL VLQSMATGAT FPEEAIADLS VNMYNRLRAT GEDENILFSP LSIALAMGMM
        70         80         90        100        110        120
ELGAQGSTQK EIRHSMGYDS LKNGEEFSFL KEFSNMVTAK ESQYVMKIAN SLFVQNGFHV
       130        140        150        160        170        180
NEEFLQMMKK YFNAAVNHVD FSQNVAVANY INKWVENNTN NLVKDLVSPR DFDAATYLAL
       190        200        210        220        230        240
INAVYFKGNW KSQFRPENTR TFSFTKDDES EVQIPMMYQQ GEFYYGEFSD GSNEAGGIYQ
       250        260        270        280        290        300
VLEIPYEGDE ISMMLVLSRQ EVPLATLEPL VKAQLVEEWA NSVKKQKVEV YLPRFTVEQE
       310        320        330        340        350        360
IDLKDVLKAL GITEIFIKDA NLTGLSDNKE IFLSKAIHKS FLEVNEEGSE AAAVSGMIAI
       370        380        390        400        410
SRMAVLYPQV IVDHPFFFLI RNRRTGTILF MGRVMHPETM NTSGHDFEEL

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q99574-17-unknown	TGATFP...	17		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99574-363-unknown	MAVLYP...	363		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31878

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ENNTNN	160	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000420133
...VLEIPY	245	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000420561
...IAISRM	362	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31878
...DFEEL	410	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
TPA_HUMAN	362	ISRM.\|.MAVL	inferred from experiment	unknown	MEROPS	Schwartz BS	Barker-Carlson K et al.:Acyl-enzyme complexes between t... (S01.232)	12228252,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)