P12259: Coagulation factor V

General Information

Protein names	- Coagulation factor V - Activated protein C cofactor - Proaccelerin, labile factor - Coagulation factor V heavy chain - Coagulation factor V light chain
Gene names	F5
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P12259

26 N-termini

20 C-termini

25 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MFPGCPRLWV LVVLGTSWVG WGSQGTEAAQ LRQFYVAAQG ISWSYRPEPT NSSLNLSVTS
        70         80         90        100        110        120
FKKIVYREYE PYFKKEKPQS TISGLLGPTL YAEVGDIIKV HFKNKADKPL SIHPQGIRYS
       130        140        150        160        170        180
KLSEGASYLD HTFPAEKMDD AVAPGREYTY EWSISEDSGP THDDPPCLTH IYYSHENLIE
       190        200        210        220        230        240
DFNSGLIGPL LICKKGTLTE GGTQKTFDKQ IVLLFAVFDE SKSWSQSSSL MYTVNGYVNG
       250        260        270        280        290        300
TMPDITVCAH DHISWHLLGM SSGPELFSIH FNGQVLEQNH HKVSAITLVS ATSTTANMTV
       310        320        330        340        350        360
GPEGKWIISS LTPKHLQAGM QAYIDIKNCP KKTRNLKKIT REQRRHMKRW EYFIAAEEVI
       370        380        390        400        410        420
WDYAPVIPAN MDKKYRSQHL DNFSNQIGKH YKKVMYTQYE DESFTKHTVN PNMKEDGILG
       430        440        450        460        470        480
PIIRAQVRDT LKIVFKNMAS RPYSIYPHGV TFSPYEDEVN SSFTSGRNNT MIRAVQPGET
       490        500        510        520        530        540
YTYKWNILEF DEPTENDAQC LTRPYYSDVD IMRDIASGLI GLLLICKSRS LDRRGIQRAA
       550        560        570        580        590        600
DIEQQAVFAV FDENKSWYLE DNINKFCENP DEVKRDDPKF YESNIMSTIN GYVPESITTL
       610        620        630        640        650        660
GFCFDDTVQW HFCSVGTQNE ILTIHFTGHS FIYGKRHEDT LTLFPMRGES VTVTMDNVGT
       670        680        690        700        710        720
WMLTSMNSSP RSKKLRLKFR DVKCIPDDDE DSYEIFEPPE STVMATRKMH DRLEPEDEES
       730        740        750        760        770        780
DADYDYQNRL AAALGIRSFR NSSLNQEEEE FNLTALALEN GTEFVSSNTD IIVGSNYSSP
       790        800        810        820        830        840
SNISKFTVNN LAEPQKAPSH QQATTAGSPL RHLIGKNSVL NSSTAEHSSP YSEDPIEDPL
       850        860        870        880        890        900
QPDVTGIRLL SLGAGEFKSQ EHAKHKGPKV ERDQAAKHRF SWMKLLAHKV GRHLSQDTGS
       910        920        930        940        950        960
PSGMRPWEDL PSQDTGSPSR MRPWKDPPSD LLLLKQSNSS KILVGRWHLA SEKGSYEIIQ
       970        980        990       1000       1010       1020
DTDEDTAVNN WLISPQNASR AWGESTPLAN KPGKQSGHPK FPRVRHKSLQ VRQDGGKSRL
      1030       1040       1050       1060       1070       1080
KKSQFLIKTR KKKKEKHTHH APLSPRTFHP LRSEAYNTFS ERRLKHSLVL HKSNETSLPT
      1090       1100       1110       1120       1130       1140
DLNQTLPSMD FGWIASLPDH NQNSSNDTGQ ASCPPGLYQT VPPEEHYQTF PIQDPDQMHS
      1150       1160       1170       1180       1190       1200
TSDPSHRSSS PELSEMLEYD RSHKSFPTDI SQMSPSSEHE VWQTVISPDL SQVTLSPELS
      1210       1220       1230       1240       1250       1260
QTNLSPDLSH TTLSPELIQR NLSPALGQMP ISPDLSHTTL SPDLSHTTLS LDLSQTNLSP
      1270       1280       1290       1300       1310       1320
ELSQTNLSPA LGQMPLSPDL SHTTLSLDFS QTNLSPELSH MTLSPELSQT NLSPALGQMP
      1330       1340       1350       1360       1370       1380
ISPDLSHTTL SLDFSQTNLS PELSQTNLSP ALGQMPLSPD PSHTTLSLDL SQTNLSPELS
      1390       1400       1410       1420       1430       1440
QTNLSPDLSE MPLFADLSQI PLTPDLDQMT LSPDLGETDL SPNFGQMSLS PDLSQVTLSP
      1450       1460       1470       1480       1490       1500
DISDTTLLPD LSQISPPPDL DQIFYPSESS QSLLLQEFNE SFPYPDLGQM PSPSSPTLND
      1510       1520       1530       1540       1550       1560
TFLSKEFNPL VIVGLSKDGT DYIEIIPKEE VQSSEDDYAE IDYVPYDDPY KTDVRTNINS
      1570       1580       1590       1600       1610       1620
SRDPDNIAAW YLRSNNGNRR NYYIAAEEIS WDYSEFVQRE TDIEDSDDIP EDTTYKKVVF
      1630       1640       1650       1660       1670       1680
RKYLDSTFTK RDPRGEYEEH LGILGPIIRA EVDDVIQVRF KNLASRPYSL HAHGLSYEKS
      1690       1700       1710       1720       1730       1740
SEGKTYEDDS PEWFKEDNAV QPNSSYTYVW HATERSGPES PGSACRAWAY YSAVNPEKDI
      1750       1760       1770       1780       1790       1800
HSGLIGPLLI CQKGILHKDS NMPMDMREFV LLFMTFDEKK SWYYEKKSRS SWRLTSSEMK
      1810       1820       1830       1840       1850       1860
KSHEFHAING MIYSLPGLKM YEQEWVRLHL LNIGGSQDIH VVHFHGQTLL ENGNKQHQLG
      1870       1880       1890       1900       1910       1920
VWPLLPGSFK TLEMKASKPG WWLLNTEVGE NQRAGMQTPF LIMDRDCRMP MGLSTGIISD
      1930       1940       1950       1960       1970       1980
SQIKASEFLG YWEPRLARLN NGGSYNAWSV EKLAAEFASK PWIQVDMQKE VIITGIQTQG
      1990       2000       2010       2020       2030       2040
AKHYLKSCYT TEFYVAYSSN QINWQIFKGN STRNVMYFNG NSDASTIKEN QFDPPIVARY
      2050       2060       2070       2080       2090       2100
IRISPTRAYN RPTLRLELQG CEVNGCSTPL GMENGKIENK QITASSFKKS WWGDYWEPFR
      2110       2120       2130       2140       2150       2160
ARLNAQGRVN AWQAKANNNK QWLEIDLLKI KKITAIITQG CKSLSSEMYV KSYTIHYSEQ
      2170       2180       2190       2200       2210       2220
GVEWKPYRLK SSMVDKIFEG NTNTKGHVKN FFNPPIISRF IRVIPKTWNQ SIALRLELFG

CDIY

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

26 N-termini - 20 C-termini - 25 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P12259-29-unknown	AQLRQF...	29	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P12259-138-unknown	MDDAVA...	138	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000439664
P12259-277-	EQNHHK...	277		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352
P12259-335-unknown	NLKKIT...	335	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27765
P12259-370-unknown	NMDKKY...	370	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9347
P12259-377-unknown	SQHLDN...	377		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P12259-393-unknown	KVMYTQ...	393		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P12259-474-unknown	AVQPGE...	474		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P12259-535-unknown	GIQRAA...	535	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27766
P12259-537-unknown	QRAADI...	537	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9348
P12259-707-unknown	RKMHDR...	707	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9349
P12259-708-unknown	KMHDRL...	708	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27767
P12259-708-unknown	KMHDRL...	708	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9640
P12259-737-unknown	RSFRNS...	737	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9350
P12259-738-unknown	SFRNSS...	738	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31763
P12259-738-unknown	SFRNSS...	738	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9603
P12259-738-unknown	SFRNSS...	738	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9641
P12259-848-unknown	RLLSLG...	848	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9351
P12259-1023-unknown	SQFLIK...	1023	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC27768
P12259-1047-unknown	TFHPLR...	1047	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31764
P12259-1047-unknown	TFHPLR...	1047	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9604
P12259-1047-unknown	TFHPLR...	1047	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9642
P12259-1053-unknown	SEAYNT...	1053		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P12259-1060-unknown	SERRLK...	1060	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4810
P12259-1221-unknown	NLSPAL...	1221	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9643
P12259-1476-unknown	QEFNES...	1476	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4811
P12259-1513-unknown	VGLSKD...	1513	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9352
P12259-1547-unknown	DDPYKT...	1547	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC4812
P12259-1574-unknown	SNNGNR...	1574	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P12259-1574-unknown	SNNGNR...	1574	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31765
P12259-1574-unknown	SNNGNR...	1574	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9605
P12259-1794-unknown	LTSSEM...	1794	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9606
P12259-1796-unknown	SSEMKK...	1796	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9353

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PKKTRN	334	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27765
...PVIPAN	369	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9347
...SLDRRG	534	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27766
...DRRGIQ	536	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9348
...TVMATR	706	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9349
...VMATRK	707	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27767
...VMATRK	707	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9640
...AALGIR	736	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9350
...ALGIRS	737	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ALGIRS	737	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31763
...ALGIRS	737	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9603
...ALGIRS	737	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9641
...DVTGIR	847	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9351
...SRLKKS	1022	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC27768
...PLSPRT	1046	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31764
...PLSPRT	1046	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9604
...PLSPRT	1046	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9642
...AYNTFS	1059	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4810
...ELIQRN	1220	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9643
...QSLLLQ	1475	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4811
...NPLVIV	1512	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9352
...DYVPYD	1546	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC4812
...AWYLRS	1573	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31765
...AWYLRS	1573	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9605
...RSSWRL	1793	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9606
...SWRLTS	1795	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9353
...GCDIY	2224	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
PROC_HUMAN	334	KTRN.\|.NLKK	inferred from experiment	unknown	MEROPS		Merops PROC_HUMAN -> FA5_HUMAN @334
ELNE_HUMAN	369	IPAN.\|.NMDK	inferred from experiment	unknown	MEROPS	Giles AR	Samis JA et al.:Human neutrophil elastase activ... (S01.131)	9242537,
PROC_HUMAN	534	DRRG.\|.GIQR	inferred from experiment	unknown	MEROPS		Merops PROC_HUMAN -> FA5_HUMAN @534
ELNE_HUMAN	536	RGIQ.\|.QRAA	inferred from experiment	unknown	MEROPS	Giles AR	Samis JA et al.:Human neutrophil elastase activ... (S01.131)	9242537,
ELNE_HUMAN	706	MATR.\|.RKMH	inferred from experiment	unknown	MEROPS	Tracy PB	Camire RM et al.:Proteolysis of factor V by cath... (S01.131)	9718313,
PROC_HUMAN	707	ATRK.\|.KMHD	inferred from experiment	unknown	MEROPS		Merops PROC_HUMAN -> FA5_HUMAN @707
FA7_HUMAN	707	ATRK.\|.KMHD	inferred from experiment	unknown	MEROPS	Esmon NL	Safa O et al.:Factor VIIa/tissue factor gener... (S01.215)	10026263,
ELNE_HUMAN	736	LGIR.\|.RSFR	inferred from experiment	unknown	MEROPS	Tracy PB	Camire RM et al.:Proteolysis of factor V by cath... (S01.133)	9718313,
THRB_HUMAN	737	GIRS.\|.SFRN	inferred from experiment	unknown	MEROPS	Esmon NL	Safa O et al.:Factor VIIa/tissue factor gener... (S01.215)	10026263,
FA10_HUMAN	737	GIRS.\|.SFRN	inferred from experiment	unknown	MEROPS	Dahlback B	Thorelli E et al.:Cleavage requirements for activ... (S01.216)	9249003,
FA7_HUMAN	737	GIRS.\|.SFRN	inferred from experiment	unknown	MEROPS	Esmon NL	Safa O et al.:Factor VIIa/tissue factor gener... (S01.215)	10026263,
ELNE_HUMAN	847	TGIR.\|.RLLS	inferred from experiment	unknown	MEROPS	Tracy PB	Camire RM et al.:Proteolysis of factor V by cath... (S01.133)	9718313,
PROC_HUMAN	1022	LKKS.\|.SQFL	inferred from experiment	unknown	MEROPS	Mann KG	Kalafatis M et al.:The mechanism of inactivation o... (S01.218)	7989361,
THRB_HUMAN	1046	SPRT.\|.TFHP	inferred from experiment	unknown	MEROPS	Esmon NL	Safa O et al.:Factor VIIa/tissue factor gener... (S01.215)	10026263,
FA10_HUMAN	1046	SPRT.\|.TFHP	inferred from experiment	unknown	MEROPS	Dahlback B	Thorelli E et al.:Cleavage requirements for activ... (S01.216)	9249003,
FA7_HUMAN	1046	SPRT.\|.TFHP	inferred from experiment	unknown	MEROPS	Esmon NL	Safa O et al.:Factor VIIa/tissue factor gener... (S01.215)	10026263,
CATG_HUMAN	1059	NTFS.\|.SERR	inferred from experiment	unknown	MEROPS	Tracy PB	Camire RM et al.:Proteolysis of factor V by cath... (S01.133)	9718313,
FA7_HUMAN	1220	IQRN.\|.NLSP	inferred from experiment	unknown	MEROPS	Esmon NL	Safa O et al.:Factor VIIa/tissue factor gener... (S01.215)	10026263,
CATG_HUMAN	1475	LLLQ.\|.QEFN	inferred from experiment	unknown	MEROPS	Tracy PB	Camire RM et al.:Proteolysis of factor V by cath... (S01.133)	9718313,
ELNE_HUMAN	1512	LVIV.\|.VGLS	inferred from experiment	unknown	MEROPS	Tracy PB	Camire RM et al.:Proteolysis of factor V by cath... (S01.133)	9718313,
CATG_HUMAN	1546	VPYD.\|.DDPY	inferred from experiment	unknown	MEROPS	Tracy PB	Camire RM et al.:Proteolysis of factor V by cath... (S01.133)	9718313,
THRB_HUMAN	1573	YLRS.\|.SNNG	inferred from experiment	unknown	MEROPS		Merops THRB_HUMAN -> FA5_HUMAN @1573
FA10_HUMAN	1573	YLRS.\|.SNNG	inferred from experiment	unknown	MEROPS	Dahlback B	Thorelli E et al.:Cleavage requirements for activ... (S01.216)	9249003,
FA10_HUMAN	1793	SWRL.\|.LTSS	inferred from experiment	unknown	MEROPS	Dahlback B	Thorelli E et al.:Cleavage requirements for activ... (S01.216)	9249003,
ELNE_HUMAN	1795	RLTS.\|.SSEM	inferred from experiment	unknown	MEROPS	Giles AR	Samis JA et al.:Human neutrophil elastase activ... (S01.131)	9242537,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)