P07225: Vitamin K-dependent protein S

General Information

Protein names	- Vitamin K-dependent protein S
Gene names	PROS1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P07225

7 N-termini

7 C-termini

4 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MRVLGGRCGA LLACLLLVLP VSEANFLSKQ QASQVLVRKR RANSLLEETK QGNLERECIE
        70         80         90        100        110        120
ELCNKEEARE VFENDPETDY FYPKYLVCLR SFQTGLFTAA RQSTNAYPDL RSCVNAIPDQ
       130        140        150        160        170        180
CSPLPCNEDG YMSCKDGKAS FTCTCKPGWQ GEKCEFDINE CKDPSNINGG CSQICDNTPG
       190        200        210        220        230        240
SYHCSCKNGF VMLSNKKDCK DVDECSLKPS ICGTAVCKNI PGDFECECPE GYRYNLKSKS
       250        260        270        280        290        300
CEDIDECSEN MCAQLCVNYP GGYTCYCDGK KGFKLAQDQK SCEVVSVCLP LNLDTKYELL
       310        320        330        340        350        360
YLAEQFAGVV LYLKFRLPEI SRFSAEFDFR TYDSEGVILY AESIDHSAWL LIALRGGKIE
       370        380        390        400        410        420
VQLKNEHTSK ITTGGDVINN GLWNMVSVEE LEHSISIKIA KEAVMDINKP GPLFKPENGL
       430        440        450        460        470        480
LETKVYFAGF PRKVESELIK PINPRLDGCI RSWNLMKQGA SGIKEIIQEK QNKHCLVTVE
       490        500        510        520        530        540
KGSYYPGSGI AQFHIDYNNV SSAEGWHVNV TLNIRPSTGT GVMLALVSGN NTVPFAVSLV
       550        560        570        580        590        600
DSTSEKSQDI LLSVENTVIY RIQALSLCSD QQSHLEFRVN RNNLELSTPL KIETISHEDL
       610        620        630        640        650        660
QRQLAVLDKA MKAKVATYLG GLPDVPFSAT PVNAFYNGCM EVNINGVQLD LDEAISKHND
       670
IRAHSCPSVW KKTKNS

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

7 N-termini - 7 C-termini - 4 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P07225-42-unknown	ANSLLE...	42	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
P07225-42-unknown	ANSLLE...	42	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16287
P07225-42-	ANSLLE...	42		Subtiligase Based Positive Selection		Wells	THP_untreated	23264352
P07225-91-unknown	SFQTGL...	91	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31752
P07225-91-unknown	SFQTGL...	91		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P07225-102-unknown	QSTNAY...	102	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC9600
P07225-102-unknown	QSTNAY...	102		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P07225-103-unknown	STNAYP...	103		unknown			Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
P07225-112-unknown	SCVNAI...	112	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC31753
P07225-132-unknown	MSCKDG...	132	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000385794
P07225-132-unknown	MSCKDG...	132	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000419616

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VRKRRA	41	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16287
...LVCLRS	90	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31752
...FTAARQ	101	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC9600
...YPDLRS	111	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31753
...HCSCKN	187	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000419616
...NKKDCK	199	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000330021
...KTKNS	676	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLK4_HUMAN	41	KRRA.\|.ANSL	inferred from experiment	unknown	MEROPS	Nelson PS	Matsumura M et al.:Substrates of the prostate-spec... (S01.251)	15389820,
THRB_HUMAN	90	CLRS.\|.SFQT	inferred from experiment	unknown	MEROPS	Griffin JH	Heeb MJ et al.:Activated protein C-dependent a... (S01.216)	12490286,
FA10_HUMAN	101	AARQ.\|.QSTN	inferred from experiment	unknown	MEROPS	Griffin JH	Heeb MJ et al.:Activated protein C-dependent a... (S01.216)	12490286,
THRB_HUMAN	111	DLRS.\|.SCVN	inferred from experiment	unknown	MEROPS	Griffin JH	Heeb MJ et al.:Activated protein C-dependent a... (S01.216)	12490286,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)