P03952: Plasma kallikrein
| Protein names | - Plasma kallikrein - 3.4.21.34 - Fletcher factor - Kininogenin - Plasma prekallikrein - PKK - Plasma kallikrein heavy chain - Plasma kallikrein light chain |
|---|---|
| Gene names | KLKB1 |
| Organism | Homo sapiens |
| Protease Family | S01.212 |
| Protease ID | S01.212 |
| Chromosome location | |
| UniProt ID | P03952 |
7
N-termini
4
C-termini
2
Cleavages
21
Substrates
Sequence
10 20 30 40 50 60
MILFKQATYF ISLFATVSCG CLTQLYENAF FRGGDVASMY TPNAQYCQMR CTFHPRCLLF
70 80 90 100 110 120
SFLPASSIND MEKRFGCFLK DSVTGTLPKV HRTGAVSGHS LKQCGHQISA CHRDIYKGVD
130 140 150 160 170 180
MRGVNFNVSK VSSVEECQKR CTNNIRCQFF SYATQTFHKA EYRNNCLLKY SPGGTPTAIK
190 200 210 220 230 240
VLSNVESGFS LKPCALSEIG CHMNIFQHLA FSDVDVARVL TPDAFVCRTI CTYHPNCLFF
250 260 270 280 290 300
TFYTNVWKIE SQRNVCLLKT SESGTPSSST PQENTISGYS LLTCKRTLPE PCHSKIYPGV
310 320 330 340 350 360
DFGGEELNVT FVKGVNVCQE TCTKMIRCQF FTYSLLPEDC KEEKCKCFLR LSMDGSPTRI
370 380 390 400 410 420
AYGTQGSSGY SLRLCNTGDN SVCTTKTSTR IVGGTNSSWG EWPWQVSLQV KLTAQRHLCG
430 440 450 460 470 480
GSLIGHQWVL TAAHCFDGLP LQDVWRIYSG ILNLSDITKD TPFSQIKEII IHQNYKVSEG
490 500 510 520 530 540
NHDIALIKLQ APLNYTEFQK PICLPSKGDT STIYTNCWVT GWGFSKEKGE IQNILQKVNI
550 560 570 580 590 600
PLVTNEECQK RYQDYKITQR MVCAGYKEGG KDACKGDSGG PLVCKHNGMW RLVGITSWGE
610 620 630
GCARREQPGV YTKVAEYMDW ILEKTQSSDG KAQMQSPA
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
7 N-termini - 4 C-termini - 2 Cleavages - 21 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| P03952-20-unknown | GCLTQL... | 20 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P03952-20-unknown | GCLTQL... | 20 | unknown | Wildes D. et al: Sampling the N-terminal proteome of human blood | 20173099 | ||||
| P03952-39-unknown | MYTPNA... | 39 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000415563 | |||
| P03952-39-unknown | MYTPNA... | 39 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000392231 | |||
| P03952-160-unknown | AEYRNN... | 160 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16696 | |||
| P03952-219-unknown | VLTPDA... | 219 | unknown | Wildes D. et al: Sampling the N-terminal proteome of human blood | 20173099 | ||||
| P03952-381-unknown | SVCTTK... | 381 | unknown | Wildes D. et al: Sampling the N-terminal proteome of human blood | 20173099 | ||||
| P03952-391-unknown | IVGGTN... | 391 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| P03952-391-unknown | IVGGTN... | 391 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9630 | |||
| P03952-561-unknown | MVCAGY... | 561 | unknown | Wildes D. et al: Sampling the N-terminal proteome of human blood | 20173099 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...QTFHKA | 159 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC16696 | |||
| ...TPTAIK | 179 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSP00000415563 | |||
| ...KTSTRI | 390 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...KTSTRI | 390 | inferred from cleavage | unknown | TopFIND | Inferred from cleavage TC9630 | |||
| ...MQSPA | 638 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| KLKB1_HUMAN | 159 | FHKA.|.AEYR | inferred from experiment | unknown | MEROPS | Merops KLKB1_HUMAN -> KLKB1_HUMAN @159 | ||
| FA12_HUMAN | 390 | STRI.|.IVGG | inferred from experiment | unknown | MEROPS | Davie EW | Chung DW et al.:Human plasma prekallikrein, a z... (S01.211) | 3521732, |
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| MMP1_HUMAN | 54 | EKRR.|.RNSG | inferred from experiment | unknown | MEROPS | Nagase H | Suzuki K et al.:Mechanisms of activation of tis... (S01.212) | 2176865, |
| NPY_HUMAN | 63 | RQRY.|.YGKR | inferred from experiment | unknown | MEROPS | Grouzmann E | Abid K et al.:Kinetic study of neuropeptide Y... (S09.003) | 19620246, |
| KLKB1_HUMAN | 159 | FHKA.|.AEYR | inferred from experiment | unknown | MEROPS | Merops KLKB1_HUMAN -> KLKB1_HUMAN @159 | ||
| UROK-Isoform2_HUMAN | 161 | RFKI.|.IIGG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16686 | ||
| UROK_HUMAN | 178 | RFKI.|.IIGG | inferred from experiment | unknown | MEROPS | Merops KLKB1_HUMAN -> UROK_HUMAN @178 | ||
| KNG1-Isoform3_HUMAN | 344 | LMKR.|.RPPG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16688 | ||
| FA12_HUMAN | 353 | LTRN.|.NGPL | inferred from experiment | unknown | MEROPS | MacGillivray RT | Cool DE et al.:Characterization of human blood... (S01.212) | 3877053, |
| KNG1-Isoform3_HUMAN | 353 | PFRS.|.SSRI | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16691 | ||
| FA12_HUMAN | 362 | GQRL.|.LRKS | inferred from experiment | unknown | MEROPS | MacGillivray RT | Cool DE et al.:Characterization of human blood... (S01.212) | 3877053, |
| FA12_HUMAN | 372 | MTRV.|.VVGG | inferred from experiment | unknown | MEROPS | MacGillivray RT | Cool DE et al.:Characterization of human blood... (S01.212) | 3877053, |
| HGFA_HUMAN | 372 | LTRV.|.VQLS | inferred from experiment | unknown | MEROPS | Kitamura N | Shimomura T et al.:Activation of the zymogen of he... (S01.212) | 8226803, |
| KNG1_HUMAN | 380 | LMKR.|.RPPG | inferred from experiment | unknown | MEROPS | Merops KLKB1_HUMAN -> KNG1_HUMAN @380 | ||
| KNG1-Isoform2_HUMAN | 380 | LMKR.|.RPPG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16688 | ||
| KNG1_HUMAN | 389 | PFRS.|.SSRI | inferred from experiment | unknown | MEROPS | Merops KLKB1_HUMAN -> KNG1_HUMAN @389 | ||
| KNG1-Isoform2_HUMAN | 389 | PFRS.|.SSRI | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16691 | ||
| HGF-Isoform3_HUMAN | 419 | LHRH.|.HIFW | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16698 | ||
| HGF_HUMAN | 424 | LHRH.|.HIFW | inferred from experiment | unknown | MEROPS | Kirchhofer D | Peek M et al.:Unusual proteolytic activation ... (S01.213) | 12372819, |
| KNG1_HUMAN | 427 | HTRR.|.RHDW | inferred from experiment | unknown | MEROPS | Tindall DJ | Charlesworth MC et al.:Kininogenase activity of prosta... (S01.161) | 10232657, |
| HGFL_HUMAN | 483 | KLRV.|.VVGG | inferred from experiment | unknown | MEROPS | Leonard EJ | Yoshikawa W et al.:Characterization of free alpha-... (S01.212) | 10068459, |
| HGF-Isoform3_HUMAN | 489 | QLRV.|.VVNG | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TC16700 | ||
| HGF_HUMAN | 494 | QLRV.|.VVNG | inferred from experiment | unknown | MEROPS | Kirchhofer D | Peek M et al.:Unusual proteolytic activation ... (S01.213) | 12372819, |