Q04756: Hepatocyte growth factor activator

General Information

Protein names	- Hepatocyte growth factor activator - HGF activator - HGFA - 3.4.21.- - Hepatocyte growth factor activator short chain - Hepatocyte growth factor activator long chain
Gene names	HGFAC
Organism	Homo sapiens
Protease Family	S01.228
Protease ID	S01.228
Chromosome location
UniProt ID	Q04756

3 N-termini

3 C-termini

3 Cleavages

3 Substrates

Sequence

        10         20         30         40         50         60
MGRWAWVPSP WPPPGLGPFL LLLLLLLLLP RGFQPQPGGN RTESPEPNAT ATPAIPTILV
        70         80         90        100        110        120
TSVTSETPAT SAPEAEGPQS GGLPPPPRAV PSSSSPQAQA LTEDGRPCRF PFRYGGRMLH
       130        140        150        160        170        180
ACTSEGSAHR KWCATTHNYD RDRAWGYCVE ATPPPGGPAA LDPCASGPCL NGGSCSNTQD
       190        200        210        220        230        240
PQSYHCSCPR AFTGKDCGTE KCFDETRYEY LEGGDRWARV RQGHVEQCEC FGGRTWCEGT
       250        260        270        280        290        300
RHTACLSSPC LNGGTCHLIV ATGTTVCACP PGFAGRLCNI EPDERCFLGN GTGYRGVAST
       310        320        330        340        350        360
SASGLSCLAW NSDLLYQELH VDSVGAAALL GLGPHAYCRN PDNDERPWCY VVKDSALSWE
       370        380        390        400        410        420
YCRLEACESL TRVQLSPDLL ATLPEPASPG RQACGRRHKK RTFLRPRIIG GSSSLPGSHP
       430        440        450        460        470        480
WLAAIYIGDS FCAGSLVHTC WVVSAAHCFS HSPPRDSVSV VLGQHFFNRT TDVTQTFGIE
       490        500        510        520        530        540
KYIPYTLYSV FNPSDHDLVL IRLKKKGDRC ATRSQFVQPI CLPEPGSTFP AGHKCQIAGW
       550        560        570        580        590        600
GHLDENVSGY SSSLREALVP LVADHKCSSP EVYGADISPN MLCAGYFDCK SDACQGDSGG
       610        620        630        640        650
PLACEKNGVA YLYGIISWGD GCGRLHKPGV YTRVANYVDW INDRIRPPRR LVAPS

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 3 Cleavages - 3 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name	Publications (PMID)
Q04756-118-unknown	MLHACT...	118		unknown		Wildes D. et al: Sampling the N-terminal proteome of human blood	20173099
Q04756-373-unknown	VQLSPD...	373	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q04756-373-unknown	VQLSPD...	373	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16703
Q04756-408-unknown	IIGGSS...	408	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q04756-408-unknown	IIGGSS...	408	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16475
Q04756-408-unknown	IIGGSS...	408	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16376

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ESLTRV	372	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16703
...FLRPRI	407	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...FLRPRI	407	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16475
...FLRPRI	407	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16376
...LVAPS	655	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLKB1_HUMAN	372	LTRV.\|.VQLS	inferred from experiment	unknown	MEROPS	Kitamura N	Shimomura T et al.:Activation of the zymogen of he... (S01.212)	8226803,
KLK5_HUMAN	407	RPRI.\|.IIGG	inferred from experiment	unknown	MEROPS	Kataoka H	Mukai S et al.:Activation of hepatocyte growth... (S01.251)	18221492,
KLK4_HUMAN	407	RPRI.\|.IIGG	inferred from experiment	unknown	MEROPS	Kataoka H	Mukai S et al.:Activation of hepatocyte growth... (S01.251)	18221492,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
HGFL_HUMAN	483	KLRV.\|.VVGG	inferred from experiment	unknown	MEROPS	Kataoka H	Kawaguchi M et al.:Hepatocyte growth factor activa... (S01.228)	19456860,
HGF-Isoform3_HUMAN	489	QLRV.\|.VVNG	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TC15210
HGF_HUMAN	494	QLRV.\|.VVNG	inferred from experiment	unknown	MEROPS		Merops HGFA_HUMAN -> HGF_HUMAN @494