P26927: Hepatocyte growth factor-like protein

General Information

Protein names	- Hepatocyte growth factor-like protein - Macrophage stimulatory protein - Macrophage-stimulating protein - MSP - Hepatocyte growth factor-like protein alpha chain - Hepatocyte growth factor-like protein beta chain
Gene names	MST1
Organism	Homo sapiens
Protease Family	S01.975
Protease ID	S01.975
Chromosome location
UniProt ID	P26927

2 N-termini

3 C-termini

3 Cleavages

1 Substrates

Sequence

        10         20         30         40         50         60
MGWLPLLLLL TQCLGVPGQR SPLNDFQVLR GTELQHLLHA VVPGPWQEDV ADAEECAGRC
        70         80         90        100        110        120
GPLMDCRAFH YNVSSHGCQL LPWTQHSPHT RLRRSGRCDL FQKKDYVRTC IMNNGVGYRG
       130        140        150        160        170        180
TMATTVGGLP CQAWSHKFPN DHKYTPTLRN GLEENFCRNP DGDPGGPWCY TTDPAVRFQS
       190        200        210        220        230        240
CGIKSCREAA CVWCNGEEYR GAVDRTESGR ECQRWDLQHP HQHPFEPGKF LDQGLDDNYC
       250        260        270        280        290        300
RNPDGSERPW CYTTDPQIER EFCDLPRCGS EAQPRQEATT VSCFRGKGEG YRGTANTTTA
       310        320        330        340        350        360
GVPCQRWDAQ IPHQHRFTPE KYACKDLREN FCRNPDGSEA PWCFTLRPGM RAAFCYQIRR
       370        380        390        400        410        420
CTDDVRPQDC YHGAGEQYRG TVSKTRKGVQ CQRWSAETPH KPQFTFTSEP HAQLEENFCR
       430        440        450        460        470        480
NPDGDSHGPW CYTMDPRTPF DYCALRRCAD DQPPSILDPP DQVQFEKCGK RVDRLDQRRS
       490        500        510        520        530        540
KLRVVGGHPG NSPWTVSLRN RQGQHFCGGS LVKEQWILTA RQCFSSCHMP LTGYEVWLGT
       550        560        570        580        590        600
LFQNPQHGEP SLQRVPVAKM VCGPSGSQLV LLKLERSVTL NQRVALICLP PEWYVVPPGT
       610        620        630        640        650        660
KCEIAGWGET KGTGNDTVLN VALLNVISNQ ECNIKHRGRV RESEMCTEGL LAPVGACEGD
       670        680        690        700        710
YGGPLACFTH NCWVLEGIII PNRVCARSRW PAVFTRVSVF VDWIHKVMRL G

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 3 Cleavages - 1 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
P26927-19-unknown	QRSPLN...	19	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P26927-484-unknown	VVGGHP...	484	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
P26927-484-unknown	VVGGHP...	484	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16702
P26927-484-unknown	VVGGHP...	484	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15212
P26927-484-unknown	VVGGHP...	484	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15213

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...KYACKD	325	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000373234
...RSKLRV	483	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RSKLRV	483	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC16702
...RSKLRV	483	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15212
...RSKLRV	483	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC15213
...VMRLG	711	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
KLKB1_HUMAN	483	KLRV.\|.VVGG	inferred from experiment	unknown	MEROPS	Leonard EJ	Yoshikawa W et al.:Characterization of free alpha-... (S01.212)	10068459,
HGFA_HUMAN	483	KLRV.\|.VVGG	inferred from experiment	unknown	MEROPS	Kataoka H	Kawaguchi M et al.:Hepatocyte growth factor activa... (S01.228)	19456860,
HGFL_HUMAN	483	KLRV.\|.VVGG	inferred from experiment	unknown	MEROPS	Leonard EJ	Skeel A et al.:alpha 1-Antichymotrypsin is the... (S01.975)	11274154,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
HGFL_HUMAN	483	KLRV.\|.VVGG	inferred from experiment	unknown	MEROPS	Leonard EJ	Skeel A et al.:alpha 1-Antichymotrypsin is the... (S01.975)	11274154,