TopFIND 4.0

P01303: Pro-neuropeptide Y

General Information

Protein names	- Pro-neuropeptide Y - Neuropeptide Y - Neuropeptide tyrosine - NPY - C-flanking peptide of NPY - CPON
Gene names	NPY
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	P01303

5

N-termini

5

C-termini

6

Cleavages

0

Substrates

Sequence

10 20 30 40 50 60
MLGNKRLGLS GLTLALSLLV CLGALAEAYP SKPDNPGEDA PAEDMARYYS ALRHYINLIT
70 80 90
RQRYGKRSSP ETLISDLLMR ESTENVPRTR LEDPAMW

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 5 C-termini - 6 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
P01303-30-unknown	PSKPDN...	30		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32156
P01303-30-unknown	PSKPDN...	30		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32164
P01303-31-unknown	SKPDNP...	31		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8479
P01303-39-unknown	DAPAED...	39		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18358
P01303-44-unknown	DMARYY...	44		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18359
P01303-64-unknown	YGKRSS...	64		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16695

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...LAEAYP	29	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32156
	...LAEAYP	29	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC32164
	...AEAYPS	30	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC8479
	...DNPGED	38	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18358
	...DAPAED	43	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC18359
	...ITRQRY	63	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC16695

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
XPP1_HUMAN	29	EAYP.\|.PSKP	inferred from experiment	unknown	MEROPS	von Horsten S	Frerker N et al.:Neuropeptide Y (NPY) cleaving e... (M24.009)	17223229,
XPP2_HUMAN	29	EAYP.\|.PSKP	inferred from experiment	unknown	MEROPS		Merops XPP2_HUMAN -> NPY_HUMAN @29
DPP4_HUMAN	30	AYPS.\|.SKPD	inferred from experiment	unknown	MEROPS	Grouzmann E	Abid K et al.:Kinetic study of neuropeptide Y... (S09.003)	19620246,
MEP1B_HUMAN	38	PGED.\|.DAPA	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
MEP1B_HUMAN	43	PAED.\|.DMAR	inferred from experiment	unknown	MEROPS	Bond JS	Bertenshaw GP et al.:Marked differences between meta... (M12.002)	11278902,
KLKB1_HUMAN	63	RQRY.\|.YGKR	inferred from experiment	unknown	MEROPS	Grouzmann E	Abid K et al.:Kinetic study of neuropeptide Y... (S09.003)	19620246,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)